一种阻止谷氨酰胺代谢的化合物可以减缓肿瘤生长，改变肿瘤微环境，促进持久和高活性抗肿瘤T细胞的产生。

Glutamine-blocking drug slows tumor growth and strengthens anti-tumor response

https://www.sciencedaily.com/releases/2019/11/191108155450.htm

Journal Reference:

1. Robert D. Leone, Liang Zhao, Judson M. Englert, Im-Meng Sun, Min-Hee Oh, Im-Hong Sun, Matthew L. Arwood, Ian A. Bettencourt, Chirag H. Patel, Jiayu Wen, Ada Tam, Richard L. Blosser, Eva Prchalova, Jesse Alt, Rana Rais, Barbara S. Slusher, Jonathan D. Powell. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science, 2019; eaav2588 DOI: 10.1126/science.aav2588