The discovery of IP3 as the calcium-mobilizing second messenger

"With Robin's verified stock of inositol 1,4,5-trisphosphate; the calcium-mobilising form of IP₃, Irene's permeabilized cells (质膜通透的大鼠胰腺腺泡细胞) and her post-doc Hans-Peter Streb performing the experiments, it was straight forward to show that IP₃ selectively evoked calcium release from a non-mitochondrial calcium store (内质网钙库).

... , Mike and Robin convey the excitement around this major discovery in a brief video (https://www.youtube.com/watch?v=iyIdLi1yIIo)."(你如果能看到“油管”的话)

Photo: Mike J. Berridge with Irene Schulz and Robin Irvine, depicting the discovery of the calcium mobilizing ability of IP_3, used by Michael J. Berridge in his lectures.

参考文献：

Streb H, Irvine RF, Berridge MJ, Schulz I (1983) Release of Ca²⁺ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306: 67-69. A total of 2, 051 cites on 31-03-2021. (原始论文被引用超过2, 000次)

以上英文文字及图片均引自：

Bootman MD, Galione A, Taylor CW (2021) A tribute to Professor Sir Michael J. Berridge FRS (1938–2020).  Biochim Biophys Acta - Mol Cell Res 1868: 119014. Published May 2021.