博文
线粒体动态变化通过代谢编程调控T细胞命运
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Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.pdf
Mitochondrial Dynamics Controls T Cell Fate through Metabolic ProgrammingHighlights
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TM cells have fused mitochondria while TE cells have fissed mitochondria
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Mitochondrial fusion protein Opa1 is required for TM cells and not TE cells
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Enforcing fusion improves adoptive cellular immunotherapy against tumors
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Cristae remodeling via fusion/fission signals metabolic adaptations in T cells
线粒体动态变化通过代谢编程调控T细胞命运，一个很有意思的文章。线粒体融合和分裂。主要观点：记忆性T细胞的线粒体主要是融合状态，而效应T细胞的线粒体主要是分裂状态。线粒体融合蛋白Opa1对于记忆性T细胞是必须的，而对于效应性T细胞则不是必须的。增强线粒体融合能够增加对肿瘤的细胞免疫治疗适应性。嵴重塑通过融合/分裂发挥对T细胞的代谢适应的调控作用。
https://wap.sciencenet.cn/blog-3349483-1072449.html
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