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Science Advances:单个基因的反复丢失和获得影响维管植物病原菌生活方式的演化

已有 364 次阅读 2020-11-26 08:42 |个人分类:每日摘要|系统分类:论文交流

Repeated gain and loss of a single gene modulates the evolution of vascular plant pathogen lifestyles

第一作者Emile Gluck-Thaler

第一单位俄亥俄州立大学

通讯作者Jonathan M. Jacobs


 Abstract 


背景回顾-1Vascular plant pathogens travel long distances through host veins, leading to life-threatening, systemic infections.


背景回顾-2In contrast, nonvascular pathogens remain restricted to infection sites, triggering localized symptom development.


提出问题:The contrasting features of vascular and nonvascular diseases suggest distinct etiologies, but the basis for each remains unclear.


主要发现:Here, we show that the hydrolase CbsA acts as a phenotypic switch between vascular and nonvascular plant pathogenesis.


结果1-比较基因组cbsA was enriched in genomes of vascular phytopathogenic bacteria in the family Xanthomonadaceae and absent in most nonvascular species.


结果2-功能鉴定CbsA expression allowed nonvascular Xanthomonas to cause vascular blight, while cbsA mutagenesis resulted in reduction of vascular or enhanced nonvascular symptom development. 


结果3-系统发育分析:Phylogenetic hypothesis testing further revealed that cbsA was lost in multiple nonvascular lineages and more recently gained by some vascular subgroups, suggesting that vascular pathogenesis is ancestral.


结论:Our results overall demonstrate how the gain and loss of single loci can facilitate the evolution of complex ecological traits.


 摘  要 


维管植物病原菌会通过维管进行传染,导致植株产生系统性的侵染病症,危及植株存活。相反,非维管植物病原菌会被限制在侵染点,诱导局部的病症发育。维管和非维管疾病的相反特性表明两个不同的病理学特征,但是背后潜在的分子机理还不清楚。本文中,作者发现水解酶CbsA是维管和非维管植物致病机制的一个表型转换因子。cbsA基因显著富集于黄单孢科的维管植物致病病原菌基因组中,而在大多数的非维管植物致病菌中缺失。CbsA的表达会使得非维管植物病原菌黄单胞菌引起维管枯萎病,而cbsA突变会导致维管病症的减少或非维管病症的增强。系统发育分析显示cbsA基因在多个非维管支系中丢失,并且近期在某些维管亚群中重新获得,说明维管病原菌是一种在进化上比较原始、古老的病原菌。本文的研究结果揭示了单个基因位点的丢失和获得会促进复杂生态性状的演化。


 通讯作者 

**Jonathan M. Jacobs**


个人简介:

威斯康星大学麦迪逊分校,学士;

威斯康星大学麦迪逊分校,博士。


研究方向:植物病理。


doi: 10.1126/sciadv.abc4516


Journal: Science Advances

Published date: Nov 13, 2020



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