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白内障治疗新方法

已有 3649 次阅读 2015-7-26 07:11 |个人分类:耳鼻喉学|系统分类:科研笔记

羊毛脂固醇(lanosterol)治疗白内障动物试验阶段。

生物通 www.ebiotrade.com

·中国科学家7月参与发表多篇Nature文章(07-28)生物通 www.ebiotrade.com
·复合维生素或降低男性白内障风险(04-30)
·李劲松研究组Cell子刊利用CRISPR-Cas9技术治愈小鼠白内障遗传病(12-11)生物通 www.ebiotrade.com
·基因技术治愈小鼠白内障遗传疾病(12-10)
·Structure封面文章:解密白内障的形成(12-09)

 

cataract  AND lanosterol

  参考消息网7月23日报道 台媒称,22日出炉的研究报告显示,经过狗狗测试,人类失明最常见的原因白内障,未来不用动刀,只要滴眼药水即可治愈。

  据台湾“中央社”22日综合外电报道,研究团队发现,用滴管将天然分子“羊毛脂固醇(lanosterol)”滴入眼中即可缩小狗狗的白内障。研究结果刊登在科学杂志《自然(Nature)》。

http://tech.sina.com.cn/d/f/2015-07-25/doc-ifxfhxmp9550990.shtml

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Lanosterol reverses protein aggregation in cataracts

Journal name:NatureYear published:(2015)DOI:doi:10.1038/nature14650Last updated: 25 July 2015 23:23:3 EDT

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statistics of 7 documents

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lanosterol synthase activity
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Enzyme Inhibitors
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Lanosterol
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oxidosqualene cyclase activity
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biosynthetic process
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Potvain F
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Magny S
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Coste H
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Walker M
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Issandou M
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Shumiya S
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Mori M
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Li G
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Nakayama J
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Sawashita J
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http://www.gopubmed.org/web/gopubmed/1?WEB013yge0vato9pyI9I1I00h001000d1002020000100100000011100040111

 7 documents found

1: Title: Lanosterol reverses protein aggregation in cataracts.
Authors: Zhao, Ling, et.al. .
Journal: Nature, 2015 .
Snippet: Our study identifies lanosterol as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for cataract prevention and treatment.
Affiliation: 1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [3] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA. State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China. 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. BGI-Shenzhen, Shenzhen 518083, China. 1] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [2] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA. Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA. 1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou 510005, China. Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] CapitalBio Genomics Co., Ltd., Dongguan 523808, China. 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 20080, China. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA. Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou 510005, China. Department of Biochemistry, University of California Riverside, Riverside, California 92521, USA. 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA. King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia. Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 20080, China. Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. 1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [3] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [4] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA [5] Veterans Administration Healthcare System, San Diego, California 92093, USA. .
Related Products: order online
2: Title: Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.
Authors: Fouchet, Marie-Hélène, et.al. .
Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem), Vol. 16 (11): 6218-32, 2008 .
Snippet: We describe the discovery of novel potent inhibitors of 2,3-oxidosqualene:lanosterol cyclase inhibitors (OSCi) from a focused pharmacophore-based screen.
Affiliation: Department of Medicinal chemistry, Laboratoire GlaxoSmithKline, 25-27 Avenue du Québec, 91951 LesUlis, France. marie-helene.fouchet@gsk.com .
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3: Title: Lanosterol synthasemutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat.
Authors: Mori, Masayuki, et.al. .
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 116 (2): 395-404, 2006 .
Snippet: Hypomorphic mutations were identified in genes for lanosterol synthase (Lss) on chromosome 20 and farnesyldiphosphatefarnesyltransferase 1 (Fdft1) on chromosome 15, both of which function in the cholesterolbiosynthesis pathway.
Affiliation: Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan. masamori@sch.md.shinshu-u.ac.jp .
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4: Title: Histopathologic findings after treatment with different oxidosqualene cyclase (OSC) inhibitors in hamsters and dogs.
Authors: Funk, J, et.al. .
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (Exp Toxicol Pathol), Vol. 57 (1): 29-38, 2005 .
Snippet: This finding was considered to be an early stage in cataract development.
Affiliation: F. Hoffmann-La Roche Ltd., Pharma Research Basel Non-Clinical Drug Safety, CH-4070 Basel, Switzerland. juergen.funk@roche.com .
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5: Title: Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor.
Authors: Cenedella, Richard J, et.al. .
Journal: Journal of lipid research (J Lipid Res), Vol. 45 (7): 1232-41, 2004 .
Snippet: Drug actions, besides reducing the availability of cholesterol, could contribute to cataractformation.
Affiliation: Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA. rcendella@kcom.edu .
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6: Title: Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse.
Authors: Pyrah, I T, et.al. .
Journal: Toxicologic pathology (Toxicol Pathol), Vol. 29 (2): 174-9, 2001 Mar-Apr .
Snippet: In dogs, the agents produced equatorial single cell necrosis and cataract in the lens (also observed clinically); atrophy, ulceration, and inflammation of the cornea; hyperkeratosis, acanthosis, hair papillary atrophy, and inflammation of the skin; and epithelial degeneration and spermgranuloma in the epididymides.
Affiliation: Safety Assessment, Alderley, AstraZeneca Pharmaceuticals, Macclesfield, Cheshire, United Kingdom. .
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7: Title: The state of neutral lipids in normal and cataractous human lenses.
Authors: Dillon, J, et.al. .
Journal: Experimental eye research (Exp Eye Res), Vol. 37 (1): 91-8, 1983 .
Snippet: Several new lens components were isolated and identified including cholesterol metabolites, and vitamin E (alpha-tocopherol).
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