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精准医学:肝癌分子靶向治疗基因知识发现

已有 2224 次阅读 2015-5-21 16:21 |个人分类:精准医学|系统分类:科研笔记

 

发现很多基因的文献相关性很高,对科研人员科研选题和在研课题有参考价值。

知识发现系统 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

A-query: antineoplastic agents and liver neoplasm...
C-query: molecular targeted therapy

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 431 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 25863 and can be accessed from the start page after you leave this session. There are 1807 terms on the current B-list (543 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 25863 started Thu May 21 02:47:40 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: antineoplastic agents and liver neoplasms Thu May 21 02:47:50 2015

A query = antineoplastic agents and liver neoplasms started Thu May 21 02:47:51 2015
A query resulted in 30232 titles
C_query_raw: molecular targeted therapy Thu May 21 02:48:19 2015

C: molecular targeted therapy 25131

A: antineoplastic agents and liver neoplasms 30232

AC: ( antineoplastic agents and liver neoplasms ) AND ( molecular targeted therapy ) 431

C_query_raw: molecular targeted therapy Thu May 21 02:48:25 2015

C: molecular targeted therapy 25131

A: antineoplastic agents and liver neoplasms 30232

AC: ( antineoplastic agents and liver neoplasms ) AND ( molecular targeted therapy ) 431

C query = molecular targeted therapy started Thu May 21 02:48:25 2015
C query resulted in 25131 titles
A AND C query resulted in 431 titles
28102 B-terms ready on Thu May 21 02:55:35 2015

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1807 B-terms left after filter executed Thu May 21 03:00:30 2015

B-list on Thu May 21 03:22:10 2015
1 endostatin
2 cox-2
3 toll receptor
4 jak stat
5 jnk
6 wnt
7 jak2
8 mdm2
9 mtor
10 akt
11 suicide gene
12 vegf
13 caspase-8
14 k ras
15 nkg2d
16 fdg
17 stat3
18 erk1
19 maspin
20 p38 mapk
21 beta catenin
22 cancer gene therapy
23 adiponectin
24 e2f1
25 caspase-3
26 ppargamma
27 her-2 neu
28 abcg2
29 autotaxin
30 p27kip1
31 caspase
32 hif-1
33 cyclin dependent kinase
34 dota
35 phosphatidylinositol 3-kinase
36 pi3k
37 her2
38 egfr tyrosine kinase
39 grp78
40 target rapamycin
41 cxcr4
42 signal regulated kinase
43 cd20
44 pten
45 her-2
46 vhl
47 xiap
48 cd147
49 survivin
50 eralpha
51 stat5
52 angiopoietin
53 chop
54 bcl xl
55 transgene expression
56 cd133
57 vegfr-2
58 retinoic acid receptor
59 mcl-1
60 jak1
61 hnf4alpha
62 fxr
63 socs1
64 microrna
65 hepcidin
66 nkt
67 promoter hypermethylation
68 mdr1
69 anti egfr
70 mda-7
71 smad
72 braf
73 estrogen receptor beta
74 ctla-4
75 c kit
76 mek
77 telomerase reverse transcriptase
78 midkine
79 angiopoietin-2
80 cyclin d1
81 jak
82 ampk
83 p70s6k
84 polo kinase
85 vegfr
86 lkb1
87 tspo
88 il-13
89 bax
90 mage
91 ercc1
92 matrix metalloproteinase
93 4-1bb
94 smac
95 hdac
96 il-24
97 gastrin releasing peptide
98 hla drb1
99 runx3
100 erbb2
101 htert promoter
102 foxo3a
103 cdk2
104 c myc
105 dlc1
106 brca1
107 bcrp
108 cdk4
109 sirtuin
110 sirt1
111 fasl
112 vegfr2
113 her2 neu
114 metabolic syndrome
115 topoisomerase i
116 pxr
117 b16
118 egfr antibody
119 c flip
120 c met
121 bcl-2
122 hif-1alpha
123 anti egfr antibody
124 p38
125 aromatase
126 fancd2
127 somatostatin receptor
128 vegf a
129 chemokine
130 nf kappab
131 mage a3
132 gsk3beta
133 chaperone
134 sox2
135 receptor tyrosine kinase
136 glycogen synthase
137 nadph oxidase
138 il-12
139 cpg island
140 lymphokine
141 notch3
142 g quadruplex
143 amphiregulin
144 lxr
145 bcl
146 synergistic antiproliferative
147 gp130
148 topoisomerase
149 mek1
150 raf-1
151 protein kinase b
152 egfr blockade
153 transgene
154 p27
155 14-3-3zeta
156 asco
157 egfr positive
158 thymidine kinase gene
159 histone deacetylase
160 il-6
161 statin
162 stat6
163 cytokine gene
164 cancer testis antigen
165 il-2
166 sonic hedgehog
167 aryl hydrocarbon receptor
168 sp1
169 hepatocyte growth factor
170 adam10
171 ezh2
172 rnai
173 ret
174 interleukin-2 gene
175 bcl2
176 lak
177 ppar gamma
178 pd l1
179 canstatin
180 ubiquitin
181 reporter gene
182 pi3 kinase
183 retrovirus mediated gene
184 virus mediated gene
185 ppar
186 axl
187 iodide symporter gene
188 sphingosine kinase
189 notch1
190 epcam
191 aav
192 single nucleotide polymorphism
193 targeted gene
194 mgmt
195 microsatellite
196 mmp-9
197 p16ink4a
198 cancer gene
199 map kinase
200 synergistic cytotoxicity
201 tim-3
202 p2y12
203 estrogen receptor alpha
204 cyclophilin
205 nrf2
206 genome wide
207 eif4e
208 hsp90
209 promyelocytic leukemia
210 saha

 

 

 



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