科研思路来自科研实践、来自文献信息、来自同行交流。

科研思路和科研选题也可以来自知识发现，在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析，知识发现只提供非相关文献中的隐含知识概念，对于扩大科研人员的研究思路、进行科研选题很有意义，这些知识点可能对科研工作有所启发，获得新的科研视角和思路，但还需要科研人员进行科学验证。

知识发现与科学发现  http://blog.sciencenet.cn/blog-280034-713521.html

这里可以看到自1986年以来，国外情报专家的很多知识发现，被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉，还没有很好地利用这种知识挖掘和信息分析的好方法。

知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546

A-query: arsenic
C-query: leukemia

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1779 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 3680 and can be accessed from the start page after you leave this session. There are 1564 terms on the current B-list (535 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

job id # 3680 started Mon May 18 20:16:03 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: arsenicMon May 18 20:16:09 2015

A query = arsenic started Mon May 18 20:16:10 2015
A query resulted in 23418 titles
C_query_raw: leukemia Mon May 18 20:16:29 2015

C: leukemia 272980

A: arsenic 23418

AC: ( arsenic ) AND ( leukemia ) 1779

C_query_raw: leukemia Mon May 18 20:16:34 2015

C: leukemia 272980

A: arsenic 23418

AC: ( arsenic ) AND ( leukemia ) 1779

C query = leukemia started Mon May 18 20:16:34 2015
C query resulted in 50000 titles
A AND C query resulted in 1779 titles
22003 B-terms ready on Mon May 18 20:21:30 2015

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1564 B-terms left after filter executed Mon May 18 20:46:27 2015

B-list on Mon May 18 20:49:37 2015
1 cox-2
2 gstm1
3 jnk
4 gstt1
5 ccaat enhancer binding
6 mdm2
7 akt
8 vegf
9 mthfr
10 zinc finger protein
11 gstp1
12 single nucleotide polymorphism
13 promoter hypermethylation
14 stat3
15 erk1
16 p38 mapk
17 c jun n
18 beta catenin
19 caspase-3
20 wnt
21 daxx
22 caspase
23 p53 codon
24 methylenetetrahydrofolate reductase
25 cyclin dependent kinase
26 jak stat
27 pi3k
28 gstt1 gene
29 signal regulated kinase
30 mtor
31 notch1
32 caspase-9
33 cpg island
34 survivin
35 microrna
36 bcl xl
37 nkg2d
38 p15ink4b
39 rassf1a
40 pml
41 herg
42 homeobox
43 cyp1a1
44 xrcc1
45 mdr1
46 mda-7
47 c jun
48 xpd
49 syk
50 ezh2
51 mek
52 ogg1
53 bcr abl
54 telomerase reverse transcriptase
55 p27
56 cyclin d1
57 rxr
58 gata-1
59 xrcc3
60 bax
61 nucleolin
62 mycn
63 socs-1
64 k ras
65 evi1
66 aryl hydrocarbon receptor
67 cdkn2a
68 foxo3a
69 dmsa
70 ercc2
71 ikappab
72 ki-67
73 h2ax
74 jnk1
75 c myc
76 caspase-8
77 tp53
78 nadph oxidase
79 snon
80 mmp-9
81 xpc
82 gene promoter
83 e2f1
84 nrf2
85 stathmin
86 genome wide
87 eif4e
88 ikkbeta
89 bcl-2
90 pten
91 hif-1alpha
92 p38
93 c jun nh2-terminal
94 dna methyltransferase
95 nf kappab
96 rho kinase
97 mmp-2
98 bcr
99 shp-1
100 snp

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=3680