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肺癌与乳腺癌BRCA2基因关联的知识发现
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科研思路来自科研实践、来自文献信息、来自同行交流。
科研思路和科研选题也可以来自知识发现，在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析，知识发现只提供非相关文献中的隐含知识概念，对于扩大科研人员的研究思路、进行科研选题很有意义，这些知识点可能对科研工作有所启发，获得新的科研视角和思路，但还需要科研人员进行科学验证。
知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
这里可以看到自1986年以来，国外情报专家的很多知识发现，被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉，还没有很好地利用这种知识挖掘和信息分析的好方法。
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546
相关研究参考文献：
BRCA2 and BRCA2 (/ˌbrækəˈtuː/[1]) are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (breast cancer 2, early onset) are maintained by the HGNC. Orthologs, styled Brca2 and Brca2, are common in other mammal species.[2] BRCA2 is a human tumor suppressor gene[3][4] (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA.[5]
http://en.wikipedia.org/wiki/BRCA2
知识发现结果如下
肺癌分子诊断研究文献的知识发现
http://blog.sciencenet.cn/blog-280034-889903.html
job id # 24857 started Wed May 13 03:02:19 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: lung neoplasmsWed May 13 03:02:33 2015
A query = lung neoplasms started Wed May 13 03:02:34 2015
A query resulted in 50000 titles
C_query_raw: molecular diagnosis Wed May 13 03:02:56 2015
C: molecular diagnosis 98910
A: lung neoplasms 218059
AC: ( lung neoplasms ) AND ( molecular diagnosis ) 2547
C_query_raw: molecular diagnosis Wed May 13 03:03:01 2015
C: molecular diagnosis 98910
A: lung neoplasms 218059
AC: ( lung neoplasms ) AND ( molecular diagnosis ) 2547
C query = molecular diagnosis started Wed May 13 03:03:01 2015
C query resulted in 50000 titles
A AND C query resulted in 2547 titles
49809 B-terms ready on Wed May 13 03:06:54 2015
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
3012 B-terms left after filter executed Wed May 13 03:09:25 2015
Viewed B-terms Wed May 13 03:24:14 2015
brca2
B-list on Wed May 13 03:30:34 2015
1 brca2
2 adiponectin
3 brca1
4 fhit
5 cox-2
6 toll receptor
7 promoter polymorphism
8 rankl
9 jnk
10 wnt
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=24857
知识发现相关研究文献
| AB literature
| B-term
| BC literature
|
| lung neoplasms | brca2 | molecular diagnosis |
| 1: A Rare Truncating BRCA2 Variant and Genetic Susceptibility to Upper Aerodigestive Tract Cancer. 2015 Add to clipboard 2: The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells. 2014 3: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 2014 4:BRCA2 Mutation Linked to Lung Cancer Risk. 2014 5: Ileal metastasis of breast cancer in a patient with a BRCA2 gene mutation: Report of a case. 2011 6: Mitomycin-induced interstitial pneumonitis in a patient with BRCA2 associated metastatic pancreatic carcinoma. 2010 7: Prevalence of the variant allele rs61764370 T>G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families. 2010 8: Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations. 2010
| 1: Breast adenocarcinoma recurring as small cell carcinoma in a patient with a germline BRCA2 mutation: clonal evolution unchecked. 2015 Add to clipboard 2: Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. 2015 3: A Novel Splice Site Mutation in the Non-coding Region of BRCA2: Implications for Fanconi Anemia and Familial Breast Cancer Diagnostics. 2014 4:BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by non-muscle myosin IIC. 2014 5: Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status. 2014 6: Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. 2014 7: gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair. 2014 8: Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer. 2014
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http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi
肺癌与乳腺癌BRCA2研究论文43篇分布如下：
检索分析系统http://www.pubmedplus.cn/
检索策略：
("lung neoplasms"[MeSH Terms] OR ("lung"[All Fields] AND "neoplasms"[All Fields]) OR "lung neoplasms"[All Fields]) AND ("breast neoplasms"[MeSH Terms] OR ("breast"[All Fields] AND "neoplasms"[All Fields]) OR "breast neoplasms"[All Fields]) AND ("genes, brca2"[MeSH Terms] OR ("genes"[All Fields] AND "brca2"[All Fields]) OR "brca2 genes"[All Fields] OR "brca2"[All Fields] OR "brca2 protein"[MeSH Terms] OR ("brca2"[All Fields] AND "protein"[All Fields]) OR "brca2 protein"[All Fields])
https://wap.sciencenet.cn/blog-280034-889911.html
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