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肺癌分子靶向治疗研究文献的知识发现

已有 1583 次阅读 2015-5-13 15:53 |个人分类:精准医学|系统分类:科研笔记

 

科研思路来自科研实践、来自文献信息、来自同行交流。

科研思路和科研选题也可以来自知识发现,在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析,知识发现只提供非相关文献中的隐含知识概念,对于扩大科研人员的研究思路、进行科研选题很有意义,这些知识点可能对科研工作有所启发,获得新的科研视角和思路,但还需要科研人员进行科学验证。

知识发现与科学发现  http://blog.sciencenet.cn/blog-280034-713521.html

这里可以看到自1986年以来,国外情报专家的很多知识发现,被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉,还没有很好地利用这种知识挖掘和信息分析的好方法。

知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546

 
A-query: lung neoplasms
C-query: molecular targeted therapy

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1847 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 24734 and can be accessed from the start page after you leave this session. There are 2539 terms on the current B-list (40 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

 

 



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