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孟山都农达(Roundup)致癌、致突变研究结果

已有 2793 次阅读 2015-3-22 10:06 |个人分类:转基因学|系统分类:科研笔记

 

世卫组织称孟山都农达除草剂可能致癌 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=876170

孟山都农达(Roundup)致癌、致突变研究结果

数据检索平台 http://toxnet.nlm.nih.gov/cgi-bin/sis/search2?@database=ccris&queryxxx=Roundup&Stemming=1&chemsyn=1&pubmed=1&and=1&od=./temp/~nQV671

全部毒理学研究数据检索结果 http://toxnet.nlm.nih.gov/cgi-bin/sis/search2

草甘膦

GLYPHOSATE
CASRN: 1071-83-6

Chemical structure for GLYPHOSATE

FULL RECORD DISPLAY
Displays all fields in the record. 

For other data, click on the Table of Contents


Substance Identification:


Substance Name:GLYPHOSATE  草甘膦  

CAS Registry Number:1071-83-6

Major Use:
HERBICIDE


Data Type:  数据类型
Carcinogenicity   致癌性
Mutagenicity  致突变性

Studies Data:   研究数据


Carcinogenicity Studies:   致癌研究结果

http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~aKT5GS:1:@od@@/cgi-bin/sis/search2/d?./temp/~smvSiW:0@

孟山都农达(Roundup)致癌、致突变研究结果CCRIS: GLYPHOSATE ISOPROPYLAMINE SALT CASRN: 38641-94-0 This record appears in multiple databases.

GLYPHOSATE ISOPROPYLAMINE SALT
CASRN: 38641-94-0

ISOPROPYLAMINE盐草甘膦

Chemical structure for GLYPHOSATE ISOPROPYLAMINE SALT
FULL RECORD DISPLAY
Displays all fields in the record. 

For other data, click on the Table of Contents


Substance Identification:


Substance Name:GLYPHOSATE ISOPROPYLAMINE SALT ISOPROPYLAMINE盐草甘膦

CAS Registry Number:38641-94-0

Major Use:
PESTICIDES (HERBICIDES)


Data Type:
Carcinogenicity
Mutagenicity

Studies Data:


Carcinogenicity Studies:   致癌研究
Species:Rat
Strain/Sex:Sprague-Dawley/Male (50/Group)
Route:Oral  口腔
Dose:0; 2000; 8000; 20,000 ppm of 96.5% glyphosate, isopropylamine salt in diet for 24 mo; study duration 24 mo
Results:Negative  阴性
Reference:

[CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION; SUMMARY OF TOXICOLOGY DATA FOR GLYPHOSATE, ISOPROPYLAMINE SALT (November 3, 1992)]

Species:Rat
Strain/Sex:Sprague-Dawley/Female (50/Group)
Route:Oral
Dose:0; 2000; 8000; 20,000 ppm of 96.5% glyphosate, isopropylamine salt in diet for 24 mo; study duration 24 mo
Tumor Site/ Type of Lesion:Adrenal cortex: carcinoma (3/50 in high dose group vs 0 in all other groups)
Results:Positive. (Department of Pesticides Regulation reviewer describes as a possible adverse effect.) 阳性
Reference:

[CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION; SUMMARY OF TOXICOLOGY DATA FOR GLYPHOSATE, ISOPROPYLAMINE SALT (November 3, 1992)]


Mutagenicity Studies:
Test System:AMES SALMONELLA TYPHIMURIUM
Strain Indicator:TA98
Metabolic Activation:S-9, AROCLOR 1254
Method:STANDARD PLATE
Dose:180-1440 UG/PLATE
Results:NEGATIVE  阴性
Reference:

[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]

Test System:AMES SALMONELLA TYPHIMURIUM
Strain Indicator:TA100
Metabolic Activation:NONE
Method:STANDARD PLATE
Dose:180-1440 UG/PLATE
Results:NEGATIVE 阴性
Reference:

[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]

Test System:AMES SALMONELLA TYPHIMURIUM
Strain Indicator:TA100
Metabolic Activation:S-9, AROCLOR 1254
Method:STANDARD PLATE
Dose:180-1440 UG/PLATE
Results:POSITIVE 阳性
Reference:

[RANK,J, JENSEN,AG, SKOV,B, PEDERSEN,LH AND JENSEN,K; GENOTOXICITY TESTING OF THE HERBICIDE ROUNDUP AND ITS ACTIVE INGREDIENT GLYPHOSATE ISOPROPYLAMINE USING THE MOUSE BONE MARROW MICRONUCLEUS TEST, SALMONELLA MUTAGENICITY TEST, AND ALLIUM ANAPHASE-TELOPHASE TEST; MUTAT. RES. 300(1):29-36, 1993]

Test System:BONE MARROW POLYCHROMATIC ERYTHROCYTES
End Point:IN VIVO MICRONUCLEUS
Species:MOUSE
Strain/Sex:SWISS/MALE, FEMALE
Route:IP 2X IN AQUEOUS SUSPENSION WITHIN 24 HR
Dose:50.0-200.0 MG/KG
Dose Regimen:48 HR TREATMENT
Results:NEGATIVE 阴性
Reference:

[GRISOLIA,CK; A COMPARISON BETWEEN MOUSE AND FISH MICRONUCLEUS TEST USING CYCLOPHOSPHAMIDE, MITOMYCIN C AND VARIOUS PESTICIDES; MUTAT. RES. 518(2): 145-150, 2002]

Test System:BOVINE LYMPHOCYTES
End Point:IN VITRO MICRONUCLEUS
Metabolic Activation:NONE
Dose:28; 56; 140; 280; 560 UM/L (TEST MATERIAL SOLVENT: WATER)
Dose Regimen:24 OR 48 HR CONTINUOUS TREATMENT
Results:NEGATIVE 阴性
Reference:

[PIESOVA,E; THE INFLUENCE OF DIFFERENT TREATMENT LENGHT ON THE INDUCTION OF MICRONUCLEI IN BOVINE LYMPHOCYTES AFTER THE EXPOSURE OF GLYPHOSATE; FOLIA VET. 48(3):130-134, 2004]


Administrative Information:


CCRIS Record Number:6431

Last Revision Date:20110526

Update History:
Complete Update on 2011-05-26
Complete Update on 2006-02-02
Complete Update on 2005-09-01
Complete Update on 04/07/1995, 7 fields added/edited/deleted.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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1. Economic analysis of alternative herbicide regimes on roundup ready soybeans. 
ROBERTS RK ; PENDERGRASS R ; HAYES RM 
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2. The response of sea urchin egg embryogenesis towards the effect of some pesticides. 
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