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多巴胺与记忆研究的知识发现

已有 3779 次阅读 2013-8-12 10:39 |个人分类:知识发现|系统分类:科研笔记| 知识, 多巴胺

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研究发现多巴胺与记忆力密切相关

多巴胺是一种神经递质,脑内多巴胺缺乏,就会出现震颤、僵直、运动迟缓等帕金森氏症症状。日本京都大学等机构的研究人员发现,多巴胺不仅会影响身体活动性,对于记忆力也发挥着重要作用。相关研究论文在线刊登在了近期出版的《神经元》杂志上。

http://www.bio360.net/news/show/6594.html

 

StartA-LiteratureC-LiteratureB-listFilterLiterature
A-query: Dopamine
C-query: memory

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 3358 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 20011 and can be accessed from the start page after you leave this session. There are 2111 terms on the current B-list (发现76个相关基因和蛋白质知识概念 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

 

 

 

job id # 20011 started Sun Aug 11 21:48:41 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Dopamine Sun Aug 11 21:48:46 2013

A query = Dopamine started Sun Aug 11 21:48:46 2013
A query resulted in 50000 titles
C_query_raw: Dopamine Sun Aug 11 21:48:55 2013

C: Dopamine 131294

A: pubmed_query_A 131294

AC: ( Dopamine ) AND ( Dopamine ) 131294

C_query_raw: memory Sun Aug 11 21:49:11 2013

C: memory 191102

A: pubmed_query_A 131294

C_query_raw: memory Sun Aug 11 21:49:11 2013

AC: ( Dopamine ) AND ( memory ) 3358

C: memory 191102

A: pubmed_query_A 131294

AC: ( Dopamine ) AND ( memory ) 3358

C_query_raw: memory Sun Aug 11 21:49:21 2013

C: memory 191102

A: pubmed_query_A 131294

AC: ( Dopamine ) AND ( memory ) 3358

C query = memory started Sun Aug 11 21:49:21 2013
C query resulted in 50000 titles
A AND C query resulted in 3358 titles
47505 B-terms ready on Sun Aug 11 21:51:28 2013

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
2111 B-terms left after filter executed Sun Aug 11 22:02:23 2013

B-list on Sun Aug 11 22:04:12 2013
1 akt
2 gdnf
3 transporter gene
4 5-ht1a
5 erp
6 bdnf
7 th1
8 ptsd
9 microrna
10 adiponectin
11 cox-2
12 a2a
13 opioid receptor
14 toll receptor
15 promoter polymorphism
16 synaptotagmin
17 reelin
18 serotonin transporter gene
19 ca1
20 jnk
21 wnt
22 fmr1
23 cannabinoid receptor
24 stat3
25 nf kappab
26 jak2
27 suppressor cytokine signaling
28 apolipoprotein e
29 mecp2
30 cit
31 vegf
32 mthfr
33 ryanodine receptor
34 creb
35 single nucleotide polymorphism
36 mtor
37 cd8
38 comt
39 ampa
40 fdg
41 abeta
42 erk1
43 gabaa
44 doublecortin
45 cb1
46 hypocretin
47 spatial learning
48 signal regulated kinase
49 ltp
50 orexin a
51 transcription factor
52 beta catenin
53 adhd
54 neurotrophin
55 kv7
56 egr-1
57 caspase-3
58 glutamate receptor
59 ppargamma
60 gp120
61 dtnbp1
62 urocortin
63 c ebp
64 serum response factor
65 cadasil
66 ppar gamma
67 adenosine a1 receptor
68 ghrelin
69 caspase
70 stat5
71 cyclin dependent kinase
72 phosphatidylinositol 3-kinase
73 pi3k
74 cnr1
75 5-ht2a
76 serotonin transporter promoter
知识发现研究论文实例

StartA-LiteratureC-LiteratureB-listFilterLiterature
AB literature

 

B-term

 

BC literature

 

Dopamine th1memory
1: Acute ethanol treatment upregulates th1, th2, and hdc in larval zebrafish in stable networks. 2013
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2: Expression of the paralogous tyrosine hydroxylase encoding genes th1 and th2 reveals the full complement of dopaminergic and noradrenergic neurons in zebrafish larval and juvenile brain. 2010
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3: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures. 2009
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4:Th1 cytokines are upregulated by adenoviral vectors in the brains of primed mice. 2008
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1: The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development. 2013
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2:Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset. 2013
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3:Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota. 2013
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4: Antigen experience shapes phenotype and function of memory Th1 cells. 2013
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5: Bim mediates the elimination of functionally unfit Th1 responders from the memory pool. 2013
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6: Recombinant BCG coexpressing Ag85B, CFP10, and interleukin-12 induces multifunctional Th1 and memory T cells in mice. 2012
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7: Isolation, expansion and characterisation of alloreactive human Th17 and Th1 cells. 2012
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数据来源   http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi



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