最新研究动态：

PNAS：快乐影响你的基因  http://www.ebiotrade.com/newsf/2013-7/2013730115933502.htm

       好的心态会对你的基因产生影响。在首个该类研究中，来自加州大学洛杉矶分校和北卡罗来纳大学的研究人员调查了积极心理状态对于人类基因表达的影响。他们发现，不同类型的快乐对人类基因组的影响有着很大的差异。研究报告在线发表在《美国科学院院刊》（PNAS）杂志上。

知识发现平台  http://arrowsmith.psych.uic.edu/cgi

Start A-Literature C-Literature B-list Filter Literature

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A-query: hedonic well-being C-query: genes The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 10 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 18335 and can be accessed from the start page after you leave this session. There are 194 terms on the current B-list (发现41 个基因和蛋白质知识概念，这些知识概念是文献中隐含的知识点，称为非相关文献的知识概念，这些文献之间没有引证关系，科研人员可以去分析这些知识点，也许从中有所科研启发。对科研有参考意义are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 18335 started Tue Jul 30 21:52:32 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: hedonic well-beingTue Jul 30 21:52:42 2013

A query = hedonic well-being started Tue Jul 30 21:52:42 2013
A query resulted in 667 titles
C_query_raw: hedonic well-being Tue Jul 30 21:52:45 2013

C: hedonic well-being 667

A: pubmed_query_A 667

AC: ( hedonic well-being ) AND ( hedonic well-being ) 667

C_query_raw: genes Tue Jul 30 21:53:06 2013

C: genes 1021055

A: pubmed_query_A 667

AC: ( hedonic well-being ) AND ( genes ) 10

C_query_raw: genes Tue Jul 30 21:53:09 2013

C: genes 1021055

A: pubmed_query_A 667

AC: ( hedonic well-being ) AND ( genes ) 10

C query = genes started Tue Jul 30 21:53:10 2013
C query resulted in 50000 titles
A AND C query resulted in 10 titles
2536 B-terms ready on Tue Jul 30 21:54:27 2013

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
194 B-terms left after filter executed Tue Jul 30 21:58:17 2013

B-list on Tue Jul 30 21:59:29 2013
1 leptin
2 cannabinoid receptor
3 erk
4 oprm1
5 ghrelin
6 vitamin d receptor
7 cb1
8 tachykinin
9 receptor gene
10 neuropeptide y
11 opioid receptor
12 cytokine
13 il-6
14 darpp-32
15 body mass index
16 hiv
17 opioid receptor gene
18 c fos
19 diabetes mellitus
20 milk
21 trait
22 obese
23 cue
24 tea
25 olfactory
26 diabetes
27 ethanol consumption
28 npy
29 na
30 anxiety
31 corn
32 obesity
33 transporter
34 neuropeptide
35 peptide gene
36 gut
37 parkinson disease
38 lime
39 fat
40 growth hormone
41 body mass

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=18335

 

知识发现实例

cb1基因与快乐hedonic well-being（AB文献） 或基因genes（BC文献）的关系研究

Start A-Literature C-Literature B-list Filter Literature

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AB literature   B-term   BC literature   hedonic well-being cb1 genes 1: Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice. 2013 Add to clipboard   1: Anandamide-CB1 Receptor Signaling Contributes to Postnatal Ethanol-Induced Neonatal Neurodegeneration, Adult Synaptic, and Memory Deficits. 2013 Add to clipboard 2:CB1 RECEPTOR SIGNALING REGULATES SOCIAL ANXIETY AND MEMORY. 2013 Add to clipboard 3: Brain regional differences in CB1 receptor adaptation and regulation of transcription. 2012 Add to clipboard 4:CB1 and CB2 Receptor Expression and Promoter Methylation in Patients with Cannabis Dependence. 2012 Add to clipboard 5: The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis. 2012 Add to clipboard 6: Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. 2012 Add to clipboard

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

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