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研究热点与前沿:cd4(+)t细胞、cd8(+)t细胞在HIV免疫过程中作用

已有 2990 次阅读 2013-5-8 08:19 |个人分类:热点前沿|系统分类:科研笔记| 免疫, 热点

       利用汤森路透科技集团的基本科学指标库(Essential Science Indicators)2004-2010间的高被引论文及其同被引聚类分析,通过同被引而密切关联的相关论文聚类形成若干个科学研究领域,由此绘制科学文献所反映的科学研究结构地图,讨论科学发展的基本格局。通过研究和揭示科学结构及其演化,为各领域研究提供一种思考问题、发现潜在交叉学科、“热点”领域。

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                    第一部分:RA 3  的基本信息

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RA ID: 3

RA的名称

cd4(+)t细胞、cd8(+)t细胞在HIV免疫过程中的作用及其对HIV的疫苗研发机制的影响

RA的关键词

human immunodeficiency virus type; immunodeficiency virus; human immunodeficiency virus; immunodeficiency virus type; t cells; simian immunodeficiency virus; human immunodeficiency; virus type; memory t cells; immunologic heterogeneity among persons who control hiv infection in the

包含RF(Hot RF)

核心论文数

被引用篇数

总被引次数

平均出版年

6(3)

35

1721

3659

2007.0

RA中包含RF的图谱

疫苗接种后猴免疫缺陷病毒SIV感染与cd4(+)t细胞的关系

RA概述

t细胞为抗HIV免疫反应的核心细胞,成熟t细胞主要为cd4(+)cd8(+)两大亚群。多年来研究结果已经证实HIV急性感染期内,病毒大量复制而cd4(+)t细胞急剧下降,具有HIV特异性的cd8(+)t细胞通过控制HIV复制延缓AIDS进程。所以多年来cd8(+)t细胞一直是国内外AIDS研究工作的重要靶标,可惜直至目前还没有比较理想的临床效果。实际上,cd8(+)t细胞的抑制作用受到cd4(+)t细胞的控制。虽然在一定时间内机体的细胞免疫应答可有效控制病毒复制,但随着病程进展和抗HIV特异性cd4(+)t细胞的丢失,HIV特异性cd8(+)t细胞应答将逐渐丧失其对病毒的控制,使得患者最终进入疾病的终末期-艾滋病期。因此,研究人员要重新审视以往以诱导特异cd8(+)t细胞应答为目的疫苗研发机制。

 

 

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           第二部分:RA 3 包含的6RF的基本信息

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RF ID: 6445

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

17

722

1397

2007.7

No

RF的关键词

human immunodeficiency virus type 1 transmission decipherment-early envelope diversification single-genome amplification-sequencing; human immunodeficiency virus type 1 gag alter capsid interactions; human immunodeficiency virus type 1 replication

RF ID: 11891

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

6

742

1684

2005.0

Yes

RF的关键词

cd4(+) t cell depletion; resting memory cd4(+) t cells depletes gut lamina propria cd4(+) t cells; cd4(+) memory t cells; progressive cd4(+) central-memory t cell decline results; cd4(+) t lymphocytes

RF ID: 10788

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

4

235

435

2006.0

Yes

RF的关键词

simian immunodeficiency virus sivmac239 infection; acute simian immunodeficiency virus challenge; pathogenic simian immunodeficiency virus sivmac239; preserved cd4(+) central memory t cells; vaccination preserves cd4 memory t cells

RF ID: 11128

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

3

61

108

2008.6

No

RF的关键词

immune control; mucosal immune responses; control hiv infection; hiv-infected cell elimination associated; lytic granule loading

RF ID: 9002

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

3

238

370

2007.3

Yes

RF的关键词

vaccine-mediated protection; phenotypically distinctive cd8(+) t cell responses; vaccinia virus induces polyfunctional; multifunctional t(h)1 cells define; t-cell quality

RF ID: 7457

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

2

148

193

2008.0

No

RF的关键词

failed hiv merck vaccine; merck hiv-1 vaccine; future vaccine development; nonhuman primate models

 

 

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          第三部分:6RF的核心论文详细列表

/******************************************************************/

 

RF ID

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

6445

17

722

1397

2007.7

No

RF的关键词

human immunodeficiency virus type 1 transmission decipherment-early envelope diversification single-genome amplification-sequencing; human immunodeficiency virus type 1 gag alter capsid interactions; human immunodeficiency virus type 1 replication

 

论文题目

被引

年份

刊名

第一作者

第一机构、国家

hiv nonprogressors preferentially maintain highly functional hiv-specific cd8(+) t cells

349

2006

BLOOD

BETTS MR

NIAID, USA

dominant influence of hla-b in mediating the potential co-evolution of hiv and hla

199

2004

NATURE

KIEPIELA P

Univ KwaZuluNatal, South Africa

cd8(+) t-cell responses to different hiv proteins have discordant associations with viral load

185

2007

NATURE MED

KIEPIELA P

Univ KwaZulu Natal, South Africa

fitness cost of escape mutations in p24 gag in association with control of human immunodeficiency virus type 1

110

2006

J VIROL

MARTINEZ-PICADO J

Peter Medawar Bldg, England

superior control of hiv-1 replication by cd8(+) t cells is reflected by their avidity, polyfunctionality, and clonal turnover

98

2007

J EXP MED

ALMEIDA JR

INSERM, France

identification and characterisation of transmitted and early founder virus envelopes in primary hiv-1 infection

92

2008

PROC NAT ACAD SCI USA

KEELE BF

Univ Alabama, USA

founder effects in the assessment of hiv polymorphisms and hla allele associations

69

2007

SCIENCE

BHATTACHARYA T

Los Alamos Natl Lab, USA

escape from the dominant hla-b27-restricted cytotoxic t-lymphocyte response in gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

54

2007

J VIROL

SCHNEIDEWIND A

MGH-E, North Ireland

escape and compensation from early hla-1357-mediated cytotoxic t-lymphocyte pressure on human immunodeficiency virus type 1 gag alter capsid interactions with cyclophilin a

47

2007

J VIROL

BROCKMAN MA

Massachusetts Gen Hosp East, USA

deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing

42

2008

J VIROL

SALAZAR-GONZALEZ JF

Univ Alabama, USA

transmission of hiv-1 gag immune escape mutations is associated with reduced viral load in linked recipients

37

2008

J EXP MED

GOEPFERT PA

Univ Alabama, USA

adaptation of hiv-1 to human leukocyte antigen class i

27

2009

NATURE

KAWASHIMA Y

Dept Paediat, England

hla-b57/b*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic t-lymphotye recognition

22

2009

J VIROL

MIURA T

Massachusetts Gen Hosp, USA

the first t cell response to transmitted/founder virus contributes to the control of acute viremia in hiv-1 infection

21

2009

J EXP MED

GOONETILLEKE N

Univ Oxford, England

genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early hiv-1 infection

19

2009

J EXP MED

SALAZAR-GONZALEZ JF

Univ Alabama, USA

protective hla class i alleles that restrict acute-phase cd8(+) t-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1

14

2009

J VIROL

WANG YYE

CNY 6625, USA

low-dose rectal inoculation of rhesus macaques by sivsme660 or sivmac251 recapitulates human mucosal infection by hiv-1

12

2009

J EXP MED

KEELE BF

Univ Alabama, USA

 

RF ID

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

11891

6

742

1684

2005.0

Yes

RF的关键词

cd4(+) t cell depletion; resting memory cd4(+) t cells depletes gut lamina propria cd4(+) t cells; cd4(+) memory t cells; progressive cd4(+) central-memory t cell decline results; cd4(+) t lymphocytes

 

论文题目

被引

年份

刊名

第一作者

第一机构、国家

cd4(+) t cell depletion during all stages of hiv disease occurs predominantly in the gastrointestinal tract

432

2004

J EXP MED

BRENCHLEY JM

NIAID, USA

massive infection and loss of memory cd4(+) t cells in multiple tissues during acute siv infection

417

2005

NATURE

MATTAPALLI JJ

NIAID, USA

peak siv replication in resting memory cd4(+) t cells depletes gut lamina propria cd4(+) t cells

354

2005

NATURE

LI QS

Univ Minnesota, USA

primary hiv-1 infection is associated with preferential depletion of cd4(+) t lymphocytes from effector sites in the gastrointestinal tract

295

2004

J EXP MED

MEHANDRU S

Rockefeller Univ, USA

insufficient production and tissue delivery of cd4(+) memory t cells in rapidly progressive simian immunodeficiency virus infection

128

2004

J EXP MED

PICKER LJ

Oregon Hlth Sci Univ, USA

progressive cd4(+) central-memory t cell decline results in cd4(+) effector-memory insufficiency and overt disease in chronic siv infection

58

2007

J EXP MED

OKOYE A

Oregon Hlth & Sci Univ, USA

 

RF ID

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

10788

4

235

435

2006.0

Yes

RF的关键词

simian immunodeficiency virus sivmac239 infection; acute simian immunodeficiency virus challenge; pathogenic simian immunodeficiency virus sivmac239; preserved cd4(+) central memory t cells; vaccination preserves cd4 memory t cells

 

论文题目

被引

年份

刊名

第一作者

第一机构、国家

preserved cd4(+) central memory t cells and survival in vaccinated siv-challenged monkeys

150

2006

SCIENCE

LETVIN NL

NIAID, USA

attenuation of simian immunodeficiency virus sivmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing gag

106

2005

J VIROL

CASIMIRO DR

Merck & Co Inc, USA

vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus sivmac239

91

2006

J VIROL

WILSON NA

Univ Wisconsin, USA

vaccination preserves cd4 memory t cells during acute simian immunodeficiency virus challenge

88

2006

J EXP MED

MATTAPALLIL JJ

NIAID, USA

 

RF ID

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

11128

3

61

108

2008.6

No

RF的关键词

immune control; mucosal immune responses; control hiv infection; hiv-infected cell elimination associated; lytic granule loading

 

论文题目

被引

年份

刊名

第一作者

第一机构、国家

genetic and immunologic heterogeneity among persons who control hiv infection in the absence of therapy

61

2008

J INFEC DIS

PEREYRA F

Harvard Univ, USA

lytic granule loading of cd8(+) t cells is required for hiv-infected cell elimination associated with immune control

33

2008

IMMUNITY

MIGUELES SA

NIAID, USA

mucosal immune responses to hiv-1 in elite controllers: a potential correlate of immune control

14

2009

BLOOD

FERRE AL

Univ Calif Davis, USA

 

RF ID

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

9002

3

238

370

2007.3

Yes

RF的关键词

vaccine-mediated protection; phenotypically distinctive cd8(+) t cell responses; vaccinia virus induces polyfunctional; multifunctional t(h)1 cells define; t-cell quality

 

论文题目

被引

年份

刊名

第一作者

第一机构、国家

multifunctional t(h)1 cells define a correlate of vaccine-mediated protection against leishmania major

157

2007

NATURE MED

DARRAH PA

NIAID, USA

t-cell quality in memory and protection: implications for vaccine design

113

2008

NAT REV IMMUNOL

SEDER RA

NIAID, USA

immunization with vaccinia virus induces polyfunctional and phenotypically distinctive cd8(+) t cell responses

100

2007

J EXP MED

PRECOPIO ML

NIAID, USA

 

RF ID

核心论文数

被引用篇数

总被引次数

平均出版年

是否为热点

7457

2

148

193

2008.0

No

RF的关键词

failed hiv merck vaccine; merck hiv-1 vaccine; future vaccine development; nonhuman primate models

 

论文题目

被引

年份

刊名

第一作者

第一机构、国家

the failed hiv merck vaccine study: a step back or a launching point for future vaccine development?

122

2008

J EXP MED

SEKALY RP

Univ Montreal, Canada

nonhuman primate models and the failure of the merck hiv-1 vaccine in humans

71

2008

NATURE MED

WATKINS DI

Univ Wisconsin, USA

 

 

 

 



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