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感染与癌症研究的知识发现

已有 3054 次阅读 2012-8-13 11:40 |个人分类:知识发现|系统分类:科研笔记| 病毒, 癌症研究, 乙型肝炎, 子宫颈癌

  原创博文,不许转载。
 
       大约200万,或者说六分之一的世界新发癌症患者是由于感染引起的。
       27种癌症在184个国家的发病率,发现它们主要由四种感染引起,即人类乳头状瘤病毒(human papillomaviruses)、幽门螺旋杆菌(Helicobacter pylori)、乙型肝炎(hepatitis B)及丙型肝炎(hepatitis C)。据信这几种细菌和病毒导致了约190万子宫颈癌、肠癌和肝癌病例。大多此类疾病出现在发展中国家。这些病原体引发的感染现在基本上都有预防或治疗的方法,如有针对乙肝病毒和人乳头瘤病毒的疫苗,对幽门螺杆菌则可用抗生素治疗。
 
检索策略:
 
A-query: Infections
C-query: cancer

 

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 10000articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 25059 and can be accessed from the start page after you leave this session. There are 8992 terms on the current B-list (感染与癌症研究的知识发现1724个文献中的隐含知识概念,对科研选题和进行中的相关科研工作有一定参考意义 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 
知识发现平台:
 
 
 
Start A-Literature C-Literature B-list Filter Literature
AB literature

B-term

BC literature

Infections risk hpv cancer
1: Genetic Variability and Phylogeny of High Risk HPV Type 16, 18, 31, 33 and 45 L1 Gene in Greek Women. 2012
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2: Comparison of the f-HPV typingTM and Hybrid Capture IIRegistered assays for detection of high-risk HPV genotypes in cervical samples. 2012
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3: Prevalence of Chlamydia trachomatis endocervical infection in systemic lupus erythematosus patients and evaluation of the risk for HPV-induced lesions. 2012
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4: Outcome of SurePathTM cervical samples reported as borderline nuclear change by cytological subtype and high-risk HPV status. 2012
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5: Clearance of high-risk HPV infection in Chinese women with normal cervical cytology. 2012
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6: Vaccine-Relevant Human Papillomavirus (HPV)Infections and Future Acquisition of High-Risk HPVTypes in Men. 2012
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7: Sexual behaviour and high-risk hpv in 15-22 year old lithuanian women. 2011
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1: Expression of high-risk HPV DNA and CK19 in pelvic lymph nodes in stage Ia-IIa cervical cancerand their clinical value. 2012
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2: Expression of mitochondrial ncRNAs is modulated by high risk HPV oncogenes. 2012
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3: In silico accelerated identification of structurally conserved CD8+ and CD4+ T-cell epitopes in high-risk HPV types. 2012
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4: [Results and cost evaluation of triage with highrisk HPV test in cervical cancer screening. A pilot study in Piedmont (North-West Italy)]. 2012
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5: CervarixRegistered: a bivalent vaccine against HPV types 16 and 18, with cross-protection against other high-risk HPV types. 2012
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           这几年,我做了大量生物医学知识发现的实例,有的发现,对科研选题和进行中的相关科研工作很有启发作用和参考意义,大家可以参考。科研人员应该自己亲自去做知识发现,而不是只做信息检索和信息分析。
 
许培扬博客   知识发现栏目
 
科研工作中如何应用在线信息分析与知识发现平台?

http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&quickforward=1&id=253311

 
生物医学知识发现实例:
 
雷帕霉素与肥胖研究的知识发现

http://blog.sciencenet.cn/blog-280034-600883.html



 


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