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关节炎遗传基因研究动态与知识发现

已有 3402 次阅读 2012-7-10 11:02 |个人分类:知识发现|系统分类:科研笔记| 知识, 遗传学, 动态, 关节炎, 遗传基因

Start A-Literature C-Literature B-list Filter Literature
A-query: matrix metalloproteinase 13
C-query: articular chondrocytes and osteoarthrit...

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 172 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 1678 and can be accessed from the start page after you leave this session. There are 333 terms on the current B-list (发现遗传基因相关知识概念94个,对科研选题和进行中的科研工作有一定启发作用和参考价值 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.
 
 
job id # 1678 started Mon Jul 9 21:52:31 2012
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: matrix metalloproteinase 13Mon Jul 9 21:52:39 2012

A query = matrix metalloproteinase 13 started Mon Jul 9 21:52:47 2012
A query resulted in 1578 titles
C_query_raw: matrix metalloproteinase 13 Mon Jul 9 21:53:14 2012

C: matrix metalloproteinase 13 1578

A: pubmed_query_A 1578

AC: ( matrix metalloproteinase 13 ) AND ( matrix metalloproteinase 13 ) 1578

C_query_raw: articular chondrocytes and osteoarthritis Mon Jul 9 21:54:00 2012

C: articular chondrocytes and osteoarthritis 2398

A: pubmed_query_A 1578

AC: ( matrix metalloproteinase 13 ) AND ( articular chondrocytes and osteoarthritis ) 172

C_query_raw: articular chondrocytes and osteoarthritis Mon Jul 9 21:54:31 2012

C: articular chondrocytes and osteoarthritis 2398

A: pubmed_query_A 1578

AC: ( matrix metalloproteinase 13 ) AND ( articular chondrocytes and osteoarthritis ) 172

C query = articular chondrocytes and osteoarthritis started Mon Jul 9 21:54:47 2012
C query resulted in 2398 titles
A AND C query resulted in 172 titles
2873 B-terms ready on Mon Jul 9 21:56:35 2012

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
333 B-terms left after filter executed Mon Jul 9 21:59:52 2012
B-list on Mon Jul 9 22:00:51 2012
1 cox-2
2 jnk
3 akt
4 vegf
5 erk1
6 beta catenin
7 smad
8 aggrecan
9 toll receptor
10 wnt
11 synovial fibroblast
12 smad3
13 map kinase
14 mmp-2
15 timp-1
16 leptin
17 signal regulated kinase
18 tissue inhibitor metalloproteinase
19 oncostatin m
20 c jun
21 adiponectin
22 promoter polymorphism
23 fibromodulin
24 matrix metalloproteinase
25 adamts-4
26 timp
27 mmp-9
28 cdna
29 jak stat
30 matrix gene
31 c fos
32 endostatin
33 p38
34 collagen induced arthritis
35 chemokine
36 nf kappab
37 cd44
38 bone morphogenetic protein
39 il-1beta
40 caspase-3
41 rankl
42 il-6
43 il-1
44 ap-1
45 promoter region
46 cathepsin k
47 gadd45beta
48 sox9
49 transcription factor
50 mmp-1
51 metalloproteinase gene
52 mmp-13
53 igf i
54 matrix metalloproteinase gene
55 rheumatoid synovial
56 leukemia inhibitory factor
57 erk
58 tgf beta1
59 caspase-8
60 ccn2
61 tgf beta
62 acl
63 human synovial
64 igf
65 interleukin
66 mmp-3
67 protein kinase c
68 jun
69 timp-2
70 bcl-2
71 pthrp
72 estrogen receptor
73 ctgf
74 endo180
75 fibroblast growth factor
76 bmp
77 mmp
78 disintegrin
79 collagen gene
80 tnf alpha
81 glucocorticoid receptor
82 hyaluronan synthase
83 mmp13
84 tlr4
85 cathepsin b
86 p53
87 bmp-2
88 hip
89 pth
90 proteoglycan
91 related oncogene alpha
92 metalloprotease
93 catabolic gene
94 estrogen receptor alpha
 
 
研究实例:
 
Start A-Literature C-Literature B-list Filter Literature
AB literature B-term BC literature
matrix metalloproteinase 13 cox-2 articular chondrocytes and os...
1: Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride. 2009
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2: The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. 2008
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1: TAK1 mediates the collagen-II-dependent induction of the COX-2 gene and PGE2 release in primary human chondrocytes. 2010
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2: Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs. 2009
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3: COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro. 2009
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4: Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes. 2008
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5: Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis. 2008
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6: Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. 2007
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7: NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. 2006
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8: Selective COX-2 inhibitor regulates the MAP kinase signaling pathway in human osteoarthritic chondrocytes after induction of nitric oxide. 2005
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9: Cross talk between COX-2 inhibitor and hyaluronic acid in osteoarthritic chondrocytes. 2004
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10: COX-2, NO, and cartilage damage and repair. 2000
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11: Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide. 1999
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研究动态文献:
 
关节炎中的表观遗传学基因开关


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