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美国媒体高度关注最新科研成果

已有 2725 次阅读 2016-11-23 09:51 |个人分类:热点前沿|系统分类:观点评述


我这里有三篇论文介绍,大家可以参考。

寨卡病毒感染研究 Nature 31 October 2016论文火爆

2016-11-23

《自然》杂志的一篇论文10月31日发表,今天的论文得分1221分,关注火爆。 寨卡病毒感染属性病 2016-11-23 快乐的早读分享: 悠闲才是真正的生活必需品 ...(27)次阅读|(0)个评论


11月7日发表的论文,今天的论文得分684分。媒体关注评论67条,微博178条。

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

Nature (2016) doi:10.1038/nature20564Received 03 October 2016 Accepted 27 October 2016 Published online 07 November 2016

http://www.nature.com/nature/journal/vaap/ncurrent/full/nature20564.html#author-information


Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
Overview of attention for article published in Nature, November 2016
Altmetric Badge
<a class="contextual-help-link" data-type="score" title="About this data" data-content="<h3>What is the Altmetric Attention Score?</h3>

The Altmetric Attention Score for a research output provides an indicator of the amount of attention that it has received. The score is derived from an automated algorithm, and represents a weighted count of the amount of attention we've picked up for a research output.

<a target="_blank" href="https://help.altmetric.com/support/solutions/articles/6000060969-how-is-the-altmetric-score-calculated-">Click here to learn more about how Altmetric Attention Scores are calculated.

" href="https://www.altmetric.com/details/13413916#" style="box-sizing:border-box;margin:0px;padding:0px;border:0px;font-style:inherit;font-variant:inherit;font-weight:inherit;font-stretch:inherit;font-size:inherit;line-height:inherit;font-family:inherit;vertical-align:baseline;color:#383844;text-decoration:none;outline:none;"> About this Attention Score
  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)
Mentioned bynews67 news outletsblogs8 blogstwitter178 tweetersfacebook5 Facebook pagesreddit1 Redditor
Readers onciteulike2 CiteULike
Title
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
Published in
Nature, November 2016
DOI10.1038/nature20564
Pubmed ID
Authors

Gopal Sapparapu, Estefania Fernandez, Nurgun Kose, Bin Cao, Julie M. Fox, Robin G. Bombardi, Haiyan Zhao, Christopher A. Nelson, Aubrey L. Bryan, Trevor Barnes, Edgar Davidson, Indira U. Mysorekar, Daved H. Fremont, Benjamin J. Doranz, Michael S. Diamond, James E. Crowe, Sapparapu, Gopal, Fernandez, Estefania, Kose, Nurgun, Cao, Bin, Fox, Julie M, Bombardi, Robin G, Zhao, Haiyan, Nelson, Christopher A, Bryan, Aubrey L, Barnes, Trevor, Davidson, Edgar, Mysorekar, Indira U, Fremont, Daved H, Doranz, Benjamin J, Diamond, Michael S, Crowe, James E

Abstract

Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defects during pregnancy(1). To develop candidate therapeutic agents against ZIKV, we isolated a panel of human monoclonal antibodies (mAbs) from subjects with prior ZIKV infection. A subset of mAbs recognized diverse epitopes on the envelope (E) protein and exhibited potently neutralizing activity. One of the most inhibitory mAbs, ZIKV-117, broadly neutralized infection of ZIKV strains corresponding to African, Asian, and American lineages. Epitope mapping studies revealed that ZIKV-117 recognized a unique quaternary epitope on the E protein dimer-dimer interface. We evaluated the therapeutic efficacy of ZIKV-117 in pregnant and non-pregnant mice. mAb treatment markedly reduced tissue pathology, placental and fetal infection, and mortality in mice. Thus, neutralizing human mAbs can protect against maternal-fetal transmission, infection and disease, and reveal important determinants for structure-based rational vaccine design efforts.

Twitter Demographics
The data shown below were collected from the profiles of 178 tweeters who shared this research output. Click here to find out more about how the information was compiled.


11月16日发表的论文,今天的论文得分高达668分,从来没有看到过。媒体的报道和评论86条。

Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication
Overview of attention for article published in The Journal of Experimental Medicine, November 2016
Altmetric Badge
<a class="contextual-help-link" data-type="score" title="About this data" data-content="<h3>What is the Altmetric Attention Score?

The Altmetric Attention Score for a research output provides an indicator of the amount of attention that it has received. The score is derived from an automated algorithm, and represents a weighted count of the amount of attention we've picked up for a research output.

<a target="_blank" href="https://help.altmetric.com/support/solutions/articles/6000060969-how-is-the-altmetric-score-calculated-">Click here to learn more about how Altmetric Attention Scores are calculated.

" href="https://www.altmetric.com/details/13699121#" style="box-sizing:border-box;margin:0px;padding:0px;border:0px;font-style:inherit;font-variant:inherit;font-weight:inherit;font-stretch:inherit;font-size:inherit;line-height:inherit;font-family:inherit;vertical-align:baseline;color:#383844;text-decoration:none;outline:none;"> About this Attention Score
  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 3,047)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)
Mentioned bynews86 news outletstwitter7 tweetersfacebook2 Facebook pages
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication
Published in
The Journal of Experimental Medicine, November 2016
DOI10.1084/jem.20161289
Pubmed ID
Authors

Shahzada Khan, Erik M. Woodruff, Martin Trapecar, Krystal A. Fontaine, Ashley Ezaki, Timothy C. Borbet, Melanie Ott, Shomyseh Sanjabi

Abstract

Understanding the host immune response to vaginal exposure to RNA viruses is required to combat sexual transmission of this class of pathogens. In this study, using lymphocytic choriomeningitis virus (LCMV) and Zika virus (ZIKV) in wild-type mice, we show that these viruses replicate in the vaginal mucosa with minimal induction of antiviral interferon and inflammatory response, causing dampened innate-mediated control of viral replication and a failure to mature local antigen-presenting cells (APCs). Enhancement of innate-mediated inflammation in the vaginal mucosa rescues this phenotype and completely inhibits ZIKV replication. To gain a better understanding of how this dampened innate immune activation in the lower female reproductive tract may also affect adaptive immunity, we modeled CD8 T cell responses using vaginal LCMV infection. We show that the lack of APC maturation in the vaginal mucosa leads to a delay in CD8 T cell activation in the draining lymph node and hinders the timely appearance of effector CD8 T cells in vaginal mucosa, thus further delaying viral control in this tissue. Our study demonstrates that vaginal tissue is exceptionally vulnerable to infection by RNA viruses and provides a conceptual framework for the male to female sexual transmission observed during ZIKV infection.

Twitter Demographics
The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

2016 Nov 16. pii: jem.20161289. [Epub ahead of print]
Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.
Author information
  • 1Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158.

  • 2Department of Medicine, University of California, San Francisco, San Francisco, CA 94143.

  • 3Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158 shomyseh.sanjabi@gladstone.ucsf.edu.

  • 4Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143.

Abstract

Understanding the host immune response to vaginal exposure to RNA viruses is required to combat sexual transmission of this class of pathogens. In this study, using lymphocytic choriomeningitis virus (LCMV) and Zika virus (ZIKV) in wild-type mice, we show that these viruses replicate in the vaginal mucosa with minimal induction of antiviral interferon and inflammatory response, causing dampened innate-mediated control of viral replication and a failure to mature local antigen-presenting cells (APCs). Enhancement of innate-mediated inflammation in the vaginal mucosa rescues this phenotype and completely inhibits ZIKV replication. To gain a better understanding of how this dampened innate immune activation in the lower female reproductive tract may also affect adaptive immunity, we modeled CD8 T cell responses using vaginal LCMV infection. We show that the lack of APC maturation in the vaginal mucosa leads to a delay in CD8 T cell activation in the draining lymph node and hinders the timely appearance of effector CD8 T cells in vaginal mucosa, thus further delaying viral control in this tissue. Our study demonstrates that vaginal tissue is exceptionally vulnerable to infection by RNA viruses and provides a conceptual framework for the male to female sexual transmission observed during ZIKV infection.

PMID: 27852793 DOI: 10.1084/jem.20161289
[PubMed - as supplied by publisher]


Khan S . Woodruff EM . Trapecar M . Fontaine KA . Ezaki A . Borbet TC . Ott M . Sanjabi S .
来源: J Exp Med ( P 0022-1007 E 1540-9538 ) IF:11.24(2015) H指数:316 年: 2016
PMID: 27852793 [Pubmed] 免疫学,1区




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