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NgAgo论文被引情况

已有 3692 次阅读 2017-8-4 09:45 |系统分类:科研笔记

NgAgo.txt

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DNA-guided genome editing using the Natronobacterium gregoryi Argonaute

作者:Gao, F (Gao, Feng)[ 1 ] ; Shen, XZ (Shen, Xiao Z.)[ 2 ] ; Jiang, F (Jiang, Feng)[ 1 ] ; Wu, YQ (Wu, Yongqiang)[ 1 ] ; Han, CY (Han, Chunyu)[ 1 ]


NATURE BIOTECHNOLOGY


卷: 34

期: 7

页: 768-+

DOI: 10.1038/nbt.3547

出版年: JUL 2016

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摘要

The RNA-guided endonuclease Cas9 has made genome editing a widely accessible technique. Similar to Cas9, endonucleases from the Argonaute protein family also use oligonucleotides as guides to degrade invasive genomes. Here we report that the Natronobacterium gregoryi Argonaute (NgAgo) is a DNA-guided endonuclease suitable for genome editing in human cells. NgAgo binds 5' phosphorylated single-stranded guide DNA (gDNA) of similar to 24 nucleotides, efficiently creates site-specific DNA double-strand breaks when loaded with the gDNA. The NgAgo-gDNA system does not require a protospacer-adjacent motif (PAM), as does Cas9, and preliminary characterization suggests a low tolerance to guide-target mismatches and high efficiency in editing (G+C)-rich genomic targets.

作者信息

通讯作者地址: Han, CY (通讯作者)

Hebei Univ Sci & Technol, Dept Biosci & Bioengn, Shijiazhuang, Hebei, Peoples R China.


地址:

[ 1 ] Hebei Univ Sci & Technol, Dept Biosci & Bioengn, Shijiazhuang, Hebei, Peoples R China
[ 2 ] Zhejiang Univ, Dept Physiol, Sch Med, Hangzhou, Zhejiang, Peoples R China


电子邮件地址:hanchunyu74@aliyun.com

基金资助致谢
基金资助机构授权号
National Science Foundation of China
31270950
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出版商

NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA

类别 / 分类

研究方向:Biotechnology & Applied Microbiology

Web of Science 类别:Biotechnology & Applied Microbiology

文献信息

文献类型:Article

语种:English

入藏号: WOS:000381335400032

PubMed ID: 27136078

ISSN: 1087-0156

eISSN: 1546-1696

期刊信息




其他信息

IDS 号: DT2TT

Web of Science 核心合集中的 "引用的参考文献": 22

Web of Science 核心合集中的 "被引频次": 53


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