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肠道微生物可能促进乳腺癌发生
最新研究表明,在结肠中发现的一种通常与结肠炎和结肠癌的发生有关的微生物也可能在某些乳腺癌的发生中发挥作用。短期暴露于产肠毒素的脆弱拟杆菌(enterotoxigenic Bacteroides fragilis,ETBF)毒素会在细胞中留下持久的“印象”,增加患癌症的风险。
https://www.sciencedaily.com/releases/2021/01/210106115710.htm
Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C. Conover Talbot, Konstantinos Konstantopoulos, Kathleen L. Gabrielson, Cynthia L. Sears, Dipali Sharma. A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes. Cancer Discovery, 2021; CD-20-0537 DOI: 10.1158/2159-8290.CD-20-0537
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