开幕式30分钟

Frank Witte, 印度尼西亚的3个本地组织者，Hendra Hermawan, Yufeng Zheng, Mark Staiger, Diego Mantovani先后发言

第一个报告人是美国University of Florida的Michele V. Manuel , 题目为：Magnesium and its alloys - An introduction to their metallurgy anddeformation behaviour ，报告包括motivation to do theMg research, general properties of Mg, deformation of Mg, ongoing research

元素的第一性原理计算

Acta materialia 58(2010) 5704

元素对晶粒尺寸影响

Y.C. Lee Metallurgical and Materials Trans A 31A 2895 (2000)

Metallurgical and Materials Trans A 44 (2012) 2905

析出物的形状对降解的影响？

Microalloying for strength

Mg-Sn-Na Pilog Mag Lett 86(2006) 443

第二个报告人是印度尼西亚的Prof. Kisjanto, University of Indonesia,题目为Toxic metals in the Human Body,

Markers of exposure

Blood & Urine: reflective of more recent, acute exposures

Longer Exposure, A metal provocation test is necessary.

Chelator –specific orientation range

Micro Trace Minerals Laboratory, www.microtrace.de

DES，biodegradable stens : FeMgZn

Fe, in murine generate a potential site for tepture of theenddotheliun, after stent degradation.

Mg, possess a functional degradation time of 30 days in vivio, muchshorter of the 3-6 window desired for BS.

Zn, outstanding corrosion behaviot, meetings a benchmark penetrationrate of 20 mm per years.

第三个报告人是美国的Huinan Liu，Department ofBioengineering, University of California, Riverside，题目为Degradation and cytocompatibility of magnesium alloys for medicalapplications - An introduction to methods and observations

Defintion of biodegradable

Capable of being broken down

Degradation mode

Slow release of degradation products toallow time for diffusion and metabolism

Gradual degradation with minimalfragmentation is preferred

Environmental factors

In vitro: media composition

In vivo: anatomical locations

PLOS ONE 8(6) e65603

Methods:

In vivo

Monitor the change of implants

In situ micro CT and 3D reconstruction ofimplant volume

Sacrifice animal and characterize theimplants at the end

特别欣赏，他们把样品放在培养皿中，隔天观察拍照，拼在一起几个月的

Combination of alloy development andsurface treatment

How to make a connection

(1)Degradation properties in vitro andDegradation properties in vivo

(2)Cytocompatibility and Biocompatibilty

Cell Culture Methods

Direct contact

Direct material exposure (Transwell insert)

Indirect contact

MTT 受镁降解影响，而BrDu assay不受，更合适。

下午第一个报告是香港中文大学的王佳力代表秦岭教授做的，题目为The role of magnesium and associated alloying elements (Ca, Zn,etc.) in human physiology and biology

从营养生物化学、临床医学角度对镁的功效做了系统综述。

Good food sources of Mg and K may be protective of bone.

Mg对endosteum和peristeum的影响机制

Proposed mechanism for neuroprotection of Mg

Propsed mechanism of the role of Mg in muscle

Glycerinated skeletal and smooth muscle: Ca and Mg dependence(Science)

Mg citrate has the laxative effect

Constipation（便秘） and Mg

Cardiovascular disease and Mg

Diabetes and Mg

介绍他们自己的工作采用的动物模型，除了正常鼠模型，还有Chronic Kidney Failure Pathological animal model

下午第二个报告是澳大利亚的Kevin Laws , School of Materials Science and Engineering, UNSW,Australia

Amorphous alloys – processing, properties and applications

Atomic packing efficiency

Vitreous vs crystalline

No shrinkage associated with theliquid-solid transformation, generally 3-5% for crystalline alloys

By manipulating the microstructure, In situmetallic glass/crystalline composites

Adding an additional foreign phase to themelt of the even the supercooled liquid.

Using the supercooled liquid state we canuse powder consolidation, foaming agents and de-alloying method to form porousstructure

We can engineer smaller implants, devicesto handle specific loads, a less invasive device, in th case of restorable implants,less materials to dissolve.

对可降解BMG，有Ca,Mg Zn和RE 基

Ti-Zr-Nb-Ta-Si-P

Au-Pd=Pt-Si-P

Mg-Zn-Ca Mg-Ag-Cu-Ca

Small 4^th element addition forMg-Zn-Ca: Na,Si, Li,Ti,Cu

会议室外面就是大海

晚上酒店经理介绍自己的理念，应该如何给予give地球，而不是take。资助本地的穷人，号召大家捐珊瑚，一个柱2美元，一个tree15美刀。