背景回顾：Reactive oxygen signaling regulates numerous biological processes, including stress responses in plants. Redox sensors transduce reactive oxygen signals into cellular responses. 

主要发现：We present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog (QSOX1) is a redox sensor that negatively regulates immunity against a bacterial pathogen. 

结果1-表达模式：The expression level of QSOX1 is inversely correlated with pathogen-induced ROS accumulation. 

结果2-功能机制：QSOX1 both senses and regulates ROS levels through interaction with and redox-mediated regulation of S-nitrosoglutathione reductase that, consistent with previous findings, influences reactive nitrogen-mediated regulation of ROS generation. 

结论：Collectively, our data indicate that QSOX1 is a redox sensor that negatively regulates plant immunity by linking reactive oxygen- and reactive nitrogen-signaling to limit ROS production.

 摘 要 

活性氧信号转导调控很多生物过程，包括植物的应激响应。氧化还原传感器会将活性氧信号转化为细胞响应。本文中，作者报道的生化证据表明，植物Quiescin巯基氧化酶同源蛋白QSOX1是一种氧化还原传感器，负调节植物对细菌病原体的免疫。QSOX1的表达水平与病原菌诱导的ROS积累呈负相关。QSOX1不仅可以通过与S-亚硝基谷胱甘肽还原酶的相互作用，还可以通过氧化还原介导的对S-亚硝基谷胱甘肽还原酶的调控，来感知和调节植株体内的ROS水平，从而影响活性氮介导的ROS形成调控。总之，本文的研究数据表明，QSOX1是一种氧化还原传感器，通过关联活性氧信号和活性氮信号来限制ROS的产生，从而负调节植物免疫。