生物机器分享 http://blog.sciencenet.cn/u/benlion 人类在地球起源,走向生物改造与机器发明,而将进入行星际文明的未来发展。

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系统医学 - 转化、个体与精准

已有 1827 次阅读 2015-8-3 09:01 |个人分类:daily0815|系统分类:科普集锦| 系统生物学, 系统医学, 系统生物医学

系统医学、系统生物医学与系统生物学的概念定义,涉及到系统理论、实验技术、计算机模拟和多层次生物系统等几个方面的整合。

几乎,国际学界的论文、论著和研究机构网页都描述到这几个方面,如,

The ZBSA is the first research center in Germany to combine, in one institute, systems biological data acquisition in the research fields of genomics, proteomics, metabolomics, life imaging and modeling.

- http://www.zbsa.de/ -

学科综合与交叉,不仅是传统意义上在生物仪器上(L.Hood)的概念,而且,关键是生物医学研究(BJ.Zeng)的概念。

Systems Biology is about combining 1)theory, 2)technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to furthermore translate mechanistic insights in biological systems to clinical application(转化), with the central aim of improving patients' quality of life. The challenge is to find theoretically well-chosen 3)models for the contextually correct and intelligible representation of 4)multi-scale biological systems. In this review, we discuss the current state of Systems Biology, highlight the emergence of Systems Biomedicine, and highlight some of the topics and views that we think are important for the efficient application of Systems Theory in Biomedicine.

- http://www.ncbi.nlm.nih.gov/pubmed/22119097/ -

以及,
Systems Biomedicine is organized around foundations, 3)computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying 2)genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon.
* Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine
* Provides precise (精准)and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable
* Includes a thorough discussion of the applications of quantitative principles to biomedical problems

I. Foundations of Systems Biology - Genomic Technologies for Systems Biology etc., II. Computational Modeling of Biological Systems - Dynamic Systems Analysis, High-level modeling of biological networks etc., III. Network Biology - Signaling Networks with Modeling Strategies etc., IV. Integrative Biology of Higher Biosystems - Systems Biology and Stem Cell Biology etc., V. Systems Medicine Applications, Systems Pharmacology.

- http://www.amazon.cn/Systems-Biomedicine-Concepts-and-Perspectives/dp/012372550X -

到2009年为止,已经出现把转化、个体化(见前一篇日记博文)和精准等概念用于深入或发展系统医学的方面或内容。



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