The cell phenotypes developing occur as the result of a complex spatiotemporal genes expression among numerous factors controlling. ----

The homeostasis or dynamics of molecules synthesis between degradation, cells proliferation between apoptosis --- The genomic stratification is the self-organization ---

I ). Structure integration- --- synergic expression of gene group (multi-genes), and this phenotype forms a functional or morphogenesis unit (module) ---the constructing of genomic stability during evolution of genetic co-adaptation---The biochemical metabolism systems include the essential systems --- adaptation systems --- program induced expression systems---.

II ). Functional adaptation- ---The sequential expression of genes chain in genomic program involves the interaction among locus of genes in chromosome, molecules network within cell and signal communication between cells --- involves a series of genes spatially and temporally expression---The stable rhythm patterns of secretary molecules regulate gene expression in bio-molecules synthesis, degradation and cells differentiation, proliferation and apoptosis.

III ). Stratified (Mutation) construction- ---: a). recombinant at same level of structure- the homologous recombination, genes rearrangement ---; b). multiple stratum structure of gene groups ---; c). mutation in gene families: --- the series of mutations ---

The recombination -- , transgenesis and amplification of genes are the dynamic procedures of genome. The artificial evolution includes the engineering evolution of biosystems by genetic and bionic engineering.

---to study the complex pattern relationship between phenotype and genotype--- involves a series of metabolism, molecular signals and genes regulated expression--- ”

“The Time of Biosystem Science and Engineering-- Artificial Biosystems---