知识发现系统和信息平台也是重要的科研信息获取途径和方法。

我的系列博文供大家参考。

信息检索系列博文  http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115380&view=me&from=space

信息分析系列博文  http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=114625&view=me&from=space

知识发现系列博文  http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space

信息检索、数据分析、知识发现都是科研人员的必备技能，一旦掌握，事半功倍。

许培扬 知识发现系列博文  http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space

科学研究与知识发现  http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=327994

       一项前沿性研究发现，如果某些基因被“删除”，人类寿命可以延长多达60%。科学家发现，如果对200多个基因进行“微调”，让它们变得不活跃，那么就可以让人类寿命延长几十年。

　　据英国《每日快报》网站10月12日报道，这项研究发现，在某些有机体身上，这一做法可以让寿命延长多达60%。这会让英国的人均寿命从81岁增加到一百多岁。

http://news.sina.com.cn/w/sy/2015-10-14/doc-ifxirmpz8317354.shtml

A-query: Gene and aging
C-query: human life-span

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 951 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 30306 and can be accessed from the start page after you leave this session. There are 1618 terms on the current B-list (601 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

发现衰老与寿命的相关基因

job id # 30306 started Tue Oct 13 17:00:09 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Gene and aging Tue Oct 13 17:00:17 2015

A query = Gene and aging started Tue Oct 13 17:00:18 2015
A query resulted in 36429 titles
C_query_raw: human life-span Tue Oct 13 17:01:59 2015

C: human life-span 11120

A: Gene and aging 36429

AC: ( Gene and aging ) AND ( human life-span ) 951

C_query_raw: human life-span Tue Oct 13 17:02:03 2015

C: human life-span 11120

A: Gene and aging 36429

AC: ( Gene and aging ) AND ( human life-span ) 951

C query = human life-span started Tue Oct 13 17:02:03 2015
C query resulted in 11120 titles
A AND C query resulted in 951 titles
22152 B-terms ready on Tue Oct 13 17:02:34 2015

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1618 B-terms left after filter executed Tue Oct 13 17:05:49 2015

B-list on Tue Oct 13 17:06:52 2015
1 adiponectin
2 brca1
3 toll receptor
4 jnk
5 wnt
6 mecp2
7 akt
8 vegf
9 ku70
10 mtor
11 huntingtin
12 frataxin
13 daf-16
14 sirtuin
15 caspase-3
16 microsatellite
17 serotonin transporter gene
18 p27kip1
19 signal regulated kinase
20 p66shc
21 helix loop helix
22 sirt3
23 caspase
24 sir2
25 cd28
26 cyclin dependent kinase
27 nestin
28 dystrophin
29 cdk2
30 mdx
31 rankl
32 pi3k
33 sp1
34 tdp-43
35 sirt1
36 cyclin e
37 htert gene
38 pten
39 jak stat
40 ucp2
41 sod1
42 prohibitin
43 mdm2
44 e2f1
45 cacna1a
46 grp78
47 anti mullerian hormone
48 parkin
49 leptin
50 k ras
51 map kinase
52 p53 tumor suppressor
53 mcl-1
54 gata-4
55 bdnf
56 microrna
57 p53 gene
58 id1
59 transporter gene
60 ts65dn
61 foxo
62 uncoupling protein
63 cip1
64 cd38
65 stat3
66 fat mass
67 prnp
68 swi
69 e polymorphism
70 brca2
71 swi snf
72 telomerase reverse transcriptase
73 klotho
74 cdna
75 cyclin d1
76 globin gene
77 adenovirus mediated gene
78 lrrk2
79 ampk
80 sgs1
81 heat shock factor
82 p16ink4a
83 lkb1
84 shc
85 bmi-1
86 bax
87 nanog
88 nod scid
89 matrix metalloproteinase
90 foxp3
91 foxo3a
92 serial analysis gene
93 peroxiredoxin
94 prion protein
95 caspase-8
96 lpr gene
97 waf1
98 apoe
99 c myc
100 mthfr

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=30306

研究课题实例

请见  AB文献与BC文献

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

• KOMP Repository

• Mouse Genome Informatics (MGI)

Symbol

Name
ID

Genetic Map

Chromosome 11
65.18 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr11:101488764-101551955bp, - strand From VEGA annotation of GRCm38 <!-- handle end   63192 bp  ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Expression

Literature Summary: (38 records)

Data Summary:Results (418)   Tissues (216)   Images (41)   Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	287
Northern blot	28
Western blot	3
RT-PCR	100

cDNA source data(136)
Other mouse links: Allen InstituteGEOExpression Atlas
Other vertebrate links: GEISHA BRCA1; Xenbasebrca1NEW

http://www.informatics.jax.org/marker/key/24690