科研思路来自科研实践、来自文献信息、来自同行交流。

科研思路和科研选题也可以来自知识发现，在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析，知识发现只提供非相关文献中的隐含知识概念，对于扩大科研人员的研究思路、进行科研选题很有意义，这些知识点可能对科研工作有所启发，获得新的科研视角和思路，但还需要科研人员进行科学验证。

知识发现与科学发现  http://blog.sciencenet.cn/blog-280034-713521.html

这里可以看到自1986年以来，国外情报专家的很多知识发现，被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉，还没有很好地利用这种知识挖掘和信息分析的好方法。

知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546

A-query: lung neoplasms
C-query: molecular diagnosis

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 2547 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 24857 and can be accessed from the start page after you leave this session. There are 3012 terms on the current B-list (634 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

job id # 24857 started Wed May 13 03:02:19 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: lung neoplasmsWed May 13 03:02:33 2015

A query = lung neoplasms started Wed May 13 03:02:34 2015
A query resulted in 50000 titles
C_query_raw: molecular diagnosis Wed May 13 03:02:56 2015

C: molecular diagnosis 98910

A: lung neoplasms 218059

AC: ( lung neoplasms ) AND ( molecular diagnosis ) 2547

C_query_raw: molecular diagnosis Wed May 13 03:03:01 2015

C: molecular diagnosis 98910

A: lung neoplasms 218059

AC: ( lung neoplasms ) AND ( molecular diagnosis ) 2547

C query = molecular diagnosis started Wed May 13 03:03:01 2015
C query resulted in 50000 titles
A AND C query resulted in 2547 titles
49809 B-terms ready on Wed May 13 03:06:54 2015

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
3012 B-terms left after filter executed Wed May 13 03:09:25 2015

B-list on Wed May 13 03:10:07 2015
1 brca2
2 adiponectin
3 brca1
4 fhit
5 cox-2
6 toll receptor
7 promoter polymorphism
8 rankl
9 jnk
10 wnt
11 rassf1a
12 jak2
13 msh2
14 ki-67
15 mlh1
16 mdm2
17 e2f1
18 akt
19 vegf
20 k ras
21 stk11
22 single nucleotide polymorphism
23 cd133
24 ca125
25 mycn
26 promoter hypermethylation
27 fdg
28 stat3
29 pten gene
30 cd147
31 wt1
32 cancer testis antigen
33 g quadruplex
34 notch3
35 vegfr-2
36 microsatellite
37 beta catenin
38 smad3
39 ppargamma
40 18f flt
41 ercc1
42 tlr4
43 braf
44 cdkn2a
45 differentially expressed gene
46 caspase
47 pax8
48 runx2
49 xpd
50 cpg island methylator
51 paxillin
52 pedf
53 ercc2
54 park2
55 microrna
56 dota
57 mthfr
58 caspase-8
59 tp53
60 pi3k
61 her2
62 cdk4
63 cftr
64 kruppel factor
65 atp7b
66 prame
67 chek2
68 vegf c
69 fgfr2
70 gstp1
71 scfv
72 cxcr4
73 mtor
74 pten
75 her-2
76 erk1
77 estrogen receptor beta
78 cancer gene expression
79 ugt1a1
80 tgfbr1
81 nanog
82 maspin
83 xiap
84 cpg island
85 angiopoietin-2
86 metastasis suppressor
87 survivin
88 runx3
89 p38 mapk
90 mll
91 methylenetetrahydrofolate reductase
92 psa
93 dc sign
94 oncogene mutation
95 tsc2
96 cancer gene therapy
97 sqstm1
98 s100a8
99 her-2 neu
100 mll gene
101 p27kip1
102 egfr status
103 myd88
104 abcg2
105 let-7
106 sall4
107 multiple endocrine neoplasia
108 ctla-4
109 cystatin c
110 nkx2-1
111 clusterin
112 tim-3
113 e2f
114 promoter methylation
115 tnm
116 c kit
117 mek
118 tgfbi
119 mta1
120 h2ax
121 bcr abl
122 anti egfr
123 cd20
124 he4
125 plgf
126 gene promoter
127 foxa1
128 cyclin d1
129 ret gene
130 tfe3
131 brca2 gene
132 tandem repeat
133 ezh2
134 gstm1
135 muc16
136 fibroblast activation protein
137 foxp3
138 grp78
139 scn5a
140 pdgfra
141 bax
142 claudin
143 matrix metalloproteinase
144 drb1
145 tp63
146 fgfr3
147 xpc
148 gstt1
149 dnmt3a
150 vhl
151 mage a3
152 nod2
153 l1cam
154 notch1
155 ret
156 epcam
157 lsd1
158 gata2
159 peroxiredoxin
160 rrna gene
161 hmlh1
162 cystatin
163 mmp-2
164 mesothelin
165 e cadherin
166 galectin-3
167 erbb2
168 men1
169 nbs1
170 dicer
171 kai1
172 aberrant promoter methylation
173 exon
174 nucleolin
175 chemokine receptor
176 cd151
177 yes associated protein
178 her2 neu
179 atp7a
180 ny eso-1
181 p53 gene
182 mmp-9
183 metabolic syndrome
184 id1
185 stk11 gene
186 genome wide
187 stat1
188 syk
189 jak1
190 rho kinase
191 pik3ca
192 bmi1
193 ret mutation
194 glut1
195 statin
196 c met
197 sox2
198 gnas1
199 rrna
200 flt1

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=24857