Altmetric得分检索分析平台 http://www.pubmedplus.cn/

       每天跟踪观察5篇论文的Altmetric得分，可以了解国际同行对这一研究领域的关注。

       11月27日《自然》（Nature）杂志上的5项新研究将焦点转向了免疫系统，来调查哪些患者有可能会对抑制PD-1蛋白活性的癌症药物产生反应，以及肿瘤触发免疫反应的机制。这种方法与之前人们尝试以肿瘤自身作为焦点来开发个体化疗法大相径庭。http://www.bio360.net/news/show/12399.html
Thomas Powles,Joseph Paul Eder,Gregg D. Fine,Fadi S. Braiteh,Yohann Loriot,Cristina Cruz,Joaquim Bellmunt,Howard A. Burris,Daniel P. Petrylak,Siew-leng Teng,Xiaodong Shen,Zachary Boyd,Priti S. Hegde,Daniel S. Chen& Nicholas J. Vogelzang.MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature, 27 November 2014; doi:10.1038/nature13904 点开看原文和Altmetric得分

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Paul C. Tumeh,Christina L. Harview,Jennifer H. Yearley,I. Peter Shintaku,Emma J. M. Taylor,Lidia Robert,Bartosz Chmielowski,Marko Spasic,Gina Henry,Voicu Ciobanu,Alisha N. West,Manuel Carmona,Christine Kivork,Elizabeth Seja,Grace Cherry,Antonio J. Gutierrez,Tristan R. Grogan,Christine Mateus,Gorana Tomasic,John A. Glaspy,Ryan O. Emerson,Harlan Robins,Robert H. Pierce,David A. Elashoff,Caroline Robert& Antoni Ribas. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature, 27 November 2014; doi:10.1038/nature13954

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Matthew M. Gubin,Xiuli Zhang,Heiko Schuster,Etienne Caron,Jeffrey P. Ward,Takuro Noguchi,Yulia Ivanova,Jasreet Hundal,Cora D. Arthur,Willem-Jan Krebber,Gwenn E. Mulder,Mireille Toebes,Matthew D. Vesely,Samuel S. K. Lam,Alan J. Korman,James P. Allison,Gordon J. Freeman,Arlene H. Sharpe,Erika L. Pearce,Ton N. Schumacher,Ruedi Aebersold,Hans-Georg Rammensee,Cornelis J. M. Melief,Elaine R. Mardis,William E. Gillanders,Maxim N. Artyomov& Robert D. Schreiber.Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature, 27 November 2014; doi:10.1038/nature13988

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Mahesh Yadav,Suchit Jhunjhunwala,Qui T. Phung,Patrick Lupardus,Joshua Tanguay,Stephanie Bumbaca,Christian Franci,Tommy K. Cheung,Jens Fritsche,Toni Weinschenk,Zora Modrusan,Ira Mellman,Jennie R. Lill& Lélia Delamarre.Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature, 27 November 2014; doi:10.1038/nature14001

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Roy S. Herbst,Jean-Charles Soria,Marcin Kowanetz,Gregg D. Fine,Omid Hamid,Michael S. Gordon,Jeffery A. Sosman,David F. McDermott,John D. Powderly,Scott N. Gettinger,Holbrook E. K. Kohrt,Leora Horn,Donald P. Lawrence,Sandra Rost,Maya Leabman,Yuanyuan Xiao,Ahmad Mokatrin,Hartmut Koeppen,Priti S. Hegde,Ira Mellman,Daniel S. Chen& F. Stephen Hodi.Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature, 27 November 2014; doi:10.1038/nature14011

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