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溶瘤病毒研究临床试验

已有 2086 次阅读 2014-10-17 10:56 |个人分类:循证医学|系统分类:科研笔记

 

全世界在研究,中国大陆还没有人研究。

 

溶瘤病毒(oncolytic virus)

  是一类具有复制能力的肿瘤杀伤型病毒,世界上最早出现溶瘤病毒的报道,是由于当时发现一名子宫颈癌患者在感染狂犬病病毒后,肿瘤随之消退。
溶瘤病毒溶瘤病毒1991年,Martuza等人在《Science》杂志发表文章,称转基因HSV在恶性胶质瘤治疗中有一定的效果以后,采用HSV进行的溶瘤病毒治疗就日益受到关注。其原理是通过对自然界存在的一些致病力较弱的病毒进行基因改造制成特殊的溶瘤病毒,利用靶细胞中抑癌基因的失活或缺陷从而选择性地感染肿瘤细胞,在其内大量复制并最终摧毁肿瘤细胞。

http://baike.so.com/doc/2645743.html

 

溶瘤病毒研究临床试验

51 studies found for:    oncolytic virus 

 

See Conditions by First Letter

 

Source:http://ClinicalTrials.gov
Region Name  Number of Studies
World51 
East Asia   [map]  3 
Europe   [map]  16 
Middle East   [map]  2 
North America31 
Canada   [map]  5  [studies]
United States   [map]  30  [studies]
Pacifica   [map]  2 
Hints:

Click on a [map] link to show a map of that region.

Click on a [studies] link to search within your current results for studies in that region. Use the back button to return to this list and try another region.

Studies with no locations are not included in the counts or on the map.

Studies with multiple locations are included in each region containing locations.
Source:http://ClinicalTrials.gov
Region Name  Number of Studies
World   [map]  51 
East Asia3 
Hong Kong1  [studies]
Korea, Republic of3  [studies]
Taiwan1  [studies]
Hints:

Click on a [map] link to show a map of that region.

Click on a [studies] link to search within your current results for studies in that region. Use the back button to return to this list and try another region.

Studies with no locations are not included in the counts or on the map.

Studies with multiple locations are included in each region containing locations.

Found 51 studies with search of:  oncolytic virus 
No Query Suggestions
Recognized Terms and Synonyms:
oncolytic virus:   35 studies
virus:   11027 studies
vira
viral
viridae
viru
oncolytic:   67 studies
Related Terms:
Click on a related term to refine your search.
This will narrow your search by adding an additional search term.
If your search becomes too narrow (finds too few studies), broaden it by removing search terms with the Refine Search page.

AAdenovirus
administered
administration
Advanced
BBiological
CCancer
Carcinoma
cell
CSF
GM-CSF
Ddose
GGM-CSF
Iin Patients
intratumoral
intravenous
MMalignant
NNeoplasms
Ooncolytic
oncolytic virus
PPhase
Phase 1
Phase I
RRecombinant
response
SSafety
Solid
Solid Tumors
Ttumor
Solid Tumors
VVaccinia
vaccinia virus
Virus
oncolytic virus
vaccinia virus


 

http://clinicaltrials.gov/ct2/results/map?term=oncolytic virus &map=ES

 



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