许培扬博客分享 http://blog.sciencenet.cn/u/xupeiyang 跟踪国际前沿 服务国内科研

博文

帕金森症和多动症的基因知识发现

已有 2166 次阅读 2014-7-24 11:42 |个人分类:知识发现|系统分类:科研笔记


科研思路来自科研实践、来自文献信息、来自同行交流。

  科研思路和科研选题也可以来自知识发现,在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析,知识发现只提供非相关文献中的隐含知识概念,对于扩大科研人员的研究思路、进行科研选题很有意义,这些知识点可能对科研工作有所启发,获得新的科研视角和思路,但还需要科研人员进行科学验证。

知识发现与科学发现  http://blog.sciencenet.cn/blog-280034-713521.html

  这里可以看到自1986年以来,国外情报专家的很多知识发现,被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉,还没有很好地利用这种知识挖掘和信息分析的好方法。

知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546


最新研究进展

最近在《Journal of Clinical Investigation》杂志发表的一项研究表明,多巴胺信号和多巴胺转运蛋白功能的改变,与神经和精神疾病有关,包括早发性帕金森症和注意力缺陷多动症(ADHD)。生物通 www.ebiotrade.com

康奈尔大学威尔康奈尔医学院的博士后研究人员Michelle Sahai指出:“目前的研究结果,为进一步探索‘多巴胺功能障碍和多巴胺转运蛋白改变如何引起脑部疾病’提供了一个关键的基础。也有助于研究人员开发新的方法,来帮助数以百万计受这些疾病折磨的人。”

http://www.ebiotrade.com/newsf/read.asp?page=2014723112251426


 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

StartA-LiteratureC-LiteratureB-listFilterLiterature
A-query: attention deficit hyperactivity disorde...
C-query: dopamine AND parkinsonism

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 32 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 259641 and can be accessed from the start page after you leave this session. There are 625 terms on the current B-list (197 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 259641 started Wed Jul 23 22:37:57 2014
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: dopamine AND parkinsonism Wed Jul 23 22:38:25 2014

A query = dopamine AND parkinsonism started Wed Jul 23 22:38:26 2014
A query resulted in 14831 titles
C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:38:51 2014

C: dopamine AND parkinsonism 14831

A: pubmed_query_A 14831

AC: ( dopamine AND parkinsonism ) AND ( dopamine AND parkinsonism ) 14831

A_query_raw: attention deficit hyperactivity disorder Wed Jul 23 22:39:10 2014

A query = attention deficit hyperactivity disorder started Wed Jul 23 22:39:18 2014
C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:39:20 2014

C: dopamine AND parkinsonism 14831

A: pubmed_query_A 24267

AC: ( attention deficit hyperactivity disorder ) AND ( dopamine AND parkinsonism ) 32

C query = dopamine AND parkinsonism started Wed Jul 23 22:39:22 2014
C query resulted in 14831 titles
A query resulted in 24267 titles
A_query_raw: attention deficit hyperactivity disorder Wed Jul 23 22:39:32 2014

A query = attention deficit hyperactivity disorder started Wed Jul 23 22:39:55 2014
C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:39:59 2014

A_query_raw: attention deficit hyperactivity disorder Wed Jul 23 22:39:59 2014

A query resulted in 24267 titles
C: dopamine AND parkinsonism 14831

A: pubmed_query_A 24267

AC: ( attention deficit hyperactivity disorder ) AND ( dopamine AND parkinsonism ) 32

A query = attention deficit hyperactivity disorder started Wed Jul 23 22:40:32 2014
C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:40:32 2014

C query = dopamine AND parkinsonism started Wed Jul 23 22:40:33 2014
C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:40:35 2014

C: dopamine AND parkinsonism 14831

A: pubmed_query_A 24267

AC: ( attention deficit hyperactivity disorder ) AND ( dopamine AND parkinsonism ) 32

A_query_raw: attention deficit hyperactivity disorder Wed Jul 23 22:40:36 2014

C: dopamine AND parkinsonism 14831

C query = dopamine AND parkinsonism started Wed Jul 23 22:40:36 2014
A query = attention deficit hyperactivity disorder started Wed Jul 23 22:40:36 2014
C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:40:37 2014

C: dopamine AND parkinsonism 14831

C query resulted in 14831 titles
A: pubmed_query_A 24267

A: pubmed_query_A 24267

AC: ( attention deficit hyperactivity disorder ) AND ( dopamine AND parkinsonism ) 32

AC: ( attention deficit hyperactivity disorder ) AND ( dopamine AND parkinsonism ) 32

C query = dopamine AND parkinsonism started Wed Jul 23 22:40:38 2014
C query = dopamine AND parkinsonism started Wed Jul 23 22:40:39 2014
A query resulted in 24267 titles
C query resulted in 14831 titles
A AND C query resulted in 32 titles
11399 B-terms ready on Wed Jul 23 22:53:20 2014

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
625 B-terms left after filter executed Wed Jul 23 23:11:10 2014

Viewed B-terms Wed Jul 23 23:12:50 2014
dopamine transporter gene

B-list on Wed Jul 23 23:14:02 2014
1 dopamine transporter gene
2 drd4
3 gdnf
4 d4 receptor gene
5 transporter gene
6 cit
7 bdnf
8 drd4 gene
9 opioid receptor
10 cyp2d6
11 cannabinoid receptor
12 dopamine d2 receptor
13 akt
14 single nucleotide polymorphism
15 dopamine receptor
16 comt
17 d2 receptor gene
18 gene environment
19 d3 receptor gene
20 glutamate receptor
21 slc6a3
22 dopamine transporter density
23 drd3
24 promoter polymorphism
25 darpp-32
26 drd2 gene
27 serotonin transporter gene
28 5-ht2a
29 genome wide
30 drd2
31 5-ht1a
32 dinucleotide repeat
33 mao
34 transporter promoter
35 dopamine receptor gene
36 p300
37 candidate gene
38 monoamine oxidase b
39 gene promoter polymorphism
40 catechol o-methyltransferase
41 hypocretin
42 receptor gene
43 cdna
44 monoamine oxidase
45 microsatellite
46 gene promoter
47 promoter region polymorphism
48 tyrosine hydroxylase
49 tic
50 intron
51 fmr1
52 d5 receptor gene
53 signal regulated kinase
54 glycogen synthase
55 sonic hedgehog
56 nr4a2
57 eralpha
58 dopa decarboxylase
59 tyrosine kinase
60 receptor drd4 gene
61 exon
62 mri
63 d3 receptor
64 catechol o-methyltransferase gene
65 pet
66 neurotrophic factor gene
67 nurr1
68 dopa
69 cb1
70 exon repeat polymorphism
71 twin
72 fdg
73 epilepsy
74 transporter gene slc6a3
75 c fos
76 fmr1 gene
77 allele
78 intronic polymorphism
79 rem
80 pacap
81 hydroxylase gene
82 tyrosine hydroxylase gene
83 microrna
84 drd1
85 essential tremor
86 leptin
87 ecd
88 grin2b
89 neurotrophin
90 gene slc6a3
91 gad65
92 d1 receptor gene
93 ltp
94 transporter
95 glycogen synthase kinase
96 fp
97 d4
98 ampa
99 immediate early gene
100 gene encoding
101 cyclin dependent kinase
102 tremor
103 gabaa
104 promoter region
105 promoter activity
106 park2
107 gene dopamine
108 d1
109 ssri
110 o-methyltransferase gene
111 myelin oligodendrocyte glycoprotein
112 gaba
113 allelic association
114 bdnf gene
115 transcription factor
116 htr2a
117 a1 allele
118 tsc2
119 ghrelin
120 d3
121 alzheimer disease
122 anxiety
123 meg
124 trh
125 trkb
126 p glycoprotein
127 enhancer
128 fosb
129 d2
130 tachykinin
131 p35
132 obesity
133 pde10a
134 3'-untranslated region
135 dystonia
136 alpha7
137 lobe
138 monoamine oxidase a
139 neuropeptide y
140 decarboxylase
141 gene association
142 trait
143 fat mass
144 snp
145 apolipoprotein e
146 parkinson disease
147 thyrotropin releasing hormone
148 hydrocephalus
149 gene transfer
150 intronic
151 lmx1b
152 dopamine beta hydroxylase
153 dopa decarboxylase gene
154 tryptophan hydroxylase
155 locus
156 ngf
157 blind
158 meta
159 5-ht
160 met
161 neurotrophin-3 gene
162 add
163 meningioma
164 pv
165 camp response element
166 factor gene
167 calmodulin
168 analysis gene
169 neurotensin
170 spatial learning
171 gene not
172 genome
173 rna binding
174 kinase
175 aav
176 sert
177 glur1
178 neuropeptide
179 cytochrome p450
180 dat gene
181 circling
182 cre
183 gene associated
184 adiposity
185 polymorphism 3'-untranslated region
186 igf i
187 fos
188 s100b
189 leg
190 pcr
191 functional promoter
192 mitochondrial
193 glucocorticoid receptor
194 ipt
195 beta hydroxylase gene
196 susceptibility gene
197 related gene



StartA-LiteratureC-LiteratureB-listFilterLiterature
AB literature


B-term


BC literature


attention deficit hyperactivi...dopamine transporter genedopamine AND parkinsonism...
1: Double Dissociation Between Lab Measures of Inattention and Impulsivity and the Dopamine Transporter Gene (DAT1) and Dopamine D4 Receptor Gene (DRD4). 2012
Add to clipboard

2: Interaction of Dopamine Transporter Gene and Observed Parenting Behaviors on Attention-Deficit/Hyperactivity Disorder: A Structural Equation Modeling Approach. 2012
Add to clipboard

3: Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder. 2012
Add to clipboard

4: Association between the dopamine transporter gene and the inattentive subtype of attention deficit hyperactivity disorder in Taiwan. 2011
Add to clipboard

5:Dopamine transporter gene moderates response to behavioral parent training in children with ADHD: A pilot study. 2011
Add to clipboard

6: Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder. 2010
Add to clipboard

7:Dopamine transporter gene variation modulates activation of striatum in youth with ADHD. 2010
Add to clipboard

8: Lack of Association Between a 3'UTR VNTR Polymorphism of Dopamine Transporter Gene (SLC6A3) and ADHD in a Brazilian Sample of Adult Patients. 2010
Add to clipboard

9: Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms. 2010
Add to clipboard

10: Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder. 2009
Add to clipboard

11: Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder. 2009
Add to clipboard

12:Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay. 2009
Add to clipboard

13: Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins. 2008
Add to clipboard

14: Lack of association of the dopamine transporter gene in a French ADHD sample. 2008
Add to clipboard

15: Pharmacogenetics of methylphenidate response in attention deficit/hyperactivity disorder: association with the dopamine transporter gene (SLC6A3). 2008
Add to clipboard

16: Association of ADHD with genetic variants in the 5'-region of the dopamine transporter gene: evidence for allelic heterogeneity. 2008
Add to clipboard

17: A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder. 2008
Add to clipboard

18: A preliminary report of the dopamine receptor D(4) and the dopamine transporter 1 gene polymorphism and its association with attention deficit hyperactivity disorder. 2008
Add to clipboard

19: A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children. 2007
Add to clipboard

20: Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD. 2007
Add to clipboard

21: A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. 2007
Add to clipboard

22: Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample. 2007
Add to clipboard

23: Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue. 2007
Add to clipboard

24: Association and linkage of allelic variants of the dopamine transporter gene in ADHD. 2007
Add to clipboard

25: Lack of association between the dopamine transporter gene 3' VNTR polymorphism and attention deficit hyperactivity disorder in Chinese Han children: case-control and family-based studies. 2007
Add to clipboard

26: Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. 2006
Add to clipboard

27: The dopamine transporter gene and the impulsivity phenotype in attention deficit hyperactivity disorder: a case-control association study in a Korean sample. 2006
Add to clipboard

28: A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. 2006
Add to clipboard

29: No association between VNTR polymorphisms of dopamine transporter gene and attention deficit hyperactivity disorder in Chinese children. 2006
Add to clipboard

30: The VNTR polymorphism in the human dopamine transporter gene: improved detection and absence of association of VNTR alleles with attention-deficit hyperactivity disorder. 2006
Add to clipboard

31: Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter gene. 2006
Add to clipboard

32: The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. 2005
Add to clipboard

33: Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1). 2005
Add to clipboard

34: Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder. 2005
Add to clipboard

35: Association of the risk allele of dopamine transporter gene (DAT1*10) in Omani male children with attention-deficit hyperactivity disorder. 2005
Add to clipboard

36: Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD). 2005
Add to clipboard

37: Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. 2005
Add to clipboard

38: Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder. 2004
Add to clipboard

39: [Association studies of G352A polymorphism of dopamine transporter gene in Han Chinese attention deficit hyperactivity disorder patients.] 2004
Add to clipboard

40:Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study. 2003
Add to clipboard

41: The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. 2003
Add to clipboard

42: Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities. 2003
Add to clipboard

43: [Association studies of dopamine D4 receptor gene and dopamine transporter gene polymorphisms in Han Chinese patients with attention deficit hyperactivity disorder] 2003
Add to clipboard

44: Segmental linkage disequilibrium within the dopamine transporter gene. 2002
Add to clipboard

45:Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder. 2002
Add to clipboard

46: A quantitative trait locus analysis of the dopamine transporter gene in adults with ADHD. 2002
Add to clipboard

47: Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. 2002
Add to clipboard

48: The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. 2001
Add to clipboard

49: Association of a polymorphism of the dopamine transporter gene with externalizing behavior problems and associated temperament traits: a longitudinal study from infancy to the mid-teens. 2001
Add to clipboard

50: Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. 2001
Add to clipboard

51: No association of the dopamine transporter gene 3' VNTR polymorphism with ADHD subtypes in a population sample of twins. 2001
Add to clipboard

52: Distribution of the 3' VNTR polymorphism in the human dopamine transporter gene in world populations. 2000
Add to clipboard

53: Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. 2000
Add to clipboard

54: A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. 2000
Add to clipboard

55: Association of the dopamine transporter gene (DAT1) with poor methylphenidate response. 1999
Add to clipboard

56: The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. 1998
Add to clipboard

57: Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. 1998
Add to clipboard

58: Association of attention-deficit disorder and the dopamine transporter gene. 1995
Add to clipboard


1: Infantile parkinsonism-dystonia due todopamine transporter gene mutations: another genetic twist. 2010
Add to clipboard

2: Serotonin anddopamine transporter genes do not influence depression in Parkinson's disease. 2009
Add to clipboard

3: 5' and 3' region variability in thedopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. 2006
Add to clipboard

4:Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease. 2004
Add to clipboard

5: The homozygote 10-copy genotype of variable number tandem repeatdopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients. 2003
Add to clipboard

6: L -dopa-induced adverse effects in PD anddopamine transporter gene polymorphism. 2003
Add to clipboard

7: Association betweendopamine transporter gene polymorphism and susceptibility to Parkinson's disease in Japan. 2002
Add to clipboard

8: Association study for Parkinson's disease and adopamine transporter gene polymorphism (1215A/G). 2002
Add to clipboard

9: No evidence of association between adopamine transporter gene polymorphism (1215A/G) and Parkinson's disease. 2001
Add to clipboard

10: [Association betweendopamine transporter gene polymorphism and Parkinson's disease] 2001
Add to clipboard

11: A single nucleotide polymorphism ofdopamine transporter gene is associated with Parkinson's disease. 2000
Add to clipboard

12: Association of thedopamine transporter gene with Parkinson's disease in Korean patients. 2000
Add to clipboard

13: [Association between genetic polymorphism ofdopamine transporter gene and susceptibility to Parkinson's disease] 2000
Add to clipboard

14: Thedopamine transporter gene and PD in a Chinese population. 1999
Add to clipboard

15: Variable number tandem repeatdopamine transporter gene polymorphism and Parkinson's disease: no association found. 1999
Add to clipboard

16: Regionaldopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains. 1998
Add to clipboard

17: Association of a polymorphism in thedopamine-transporter gene with Parkinson's disease. 1997
Add to clipboard

18: Thedopamine transporter gene and Parkinson's disease in a Chinese population. 1997
Add to clipboard

19: Human and mousedopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. 1995
Add to clipboard




http://wap.sciencenet.cn/blog-280034-814265.html

上一篇:不管真假,收藏再说
下一篇:逮不完的“大老虎”

2 侯成亚 Vetaren11

该博文允许注册用户评论 请点击登录 评论 (0 个评论)

数据加载中...
扫一扫,分享此博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2021-1-22 22:13

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部