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科研思路来自科研实践、来自文献信息、来自同行交流。
科研思路和科研选题也可以来自知识发现,在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析,知识发现只提供非相关文献中的隐含知识概念,对于扩大科研人员的研究思路、进行科研选题很有意义,这些知识点可能对科研工作有所启发,获得新的科研视角和思路,但还需要科研人员进行科学验证。
知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
这里可以看到自1986年以来,国外情报专家的很多知识发现,被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉,还没有很好地利用这种知识挖掘和信息分析的好方法。
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546
最新研究进展
最近在《Journal of Clinical Investigation》杂志发表的一项研究表明,多巴胺信号和多巴胺转运蛋白功能的改变,与神经和精神疾病有关,包括早发性帕金森症和注意力缺陷多动症(ADHD)。生物通 www.ebiotrade.com
康奈尔大学威尔康奈尔医学院的博士后研究人员Michelle Sahai指出:“目前的研究结果,为进一步探索‘多巴胺功能障碍和多巴胺转运蛋白改变如何引起脑部疾病’提供了一个关键的基础。也有助于研究人员开发新的方法,来帮助数以百万计受这些疾病折磨的人。”
http://www.ebiotrade.com/newsf/read.asp?page=2014723112251426
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
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A-query: attention deficit hyperactivity disorde... C-query: dopamine AND parkinsonism The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 32 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 259641 and can be accessed from the start page after you leave this session. There are 625 terms on the current B-list (197 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. |
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C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:39:59 2014
A_query_raw: attention deficit hyperactivity disorder Wed Jul 23 22:39:59 2014
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C_query_raw: dopamine AND parkinsonism Wed Jul 23 22:40:35 2014
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C query = dopamine AND parkinsonism started Wed Jul 23 22:40:36 2014
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A: pubmed_query_A 24267
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AC: ( attention deficit hyperactivity disorder ) AND ( dopamine AND parkinsonism ) 32
C query = dopamine AND parkinsonism started Wed Jul 23 22:40:38 2014
C query = dopamine AND parkinsonism started Wed Jul 23 22:40:39 2014
A query resulted in 24267 titles
C query resulted in 14831 titles
A AND C query resulted in 32 titles
11399 B-terms ready on Wed Jul 23 22:53:20 2014
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
625 B-terms left after filter executed Wed Jul 23 23:11:10 2014
Viewed B-terms Wed Jul 23 23:12:50 2014
dopamine transporter gene
B-list on Wed Jul 23 23:14:02 2014
1 dopamine transporter gene
2 drd4
3 gdnf
4 d4 receptor gene
5 transporter gene
6 cit
7 bdnf
8 drd4 gene
9 opioid receptor
10 cyp2d6
11 cannabinoid receptor
12 dopamine d2 receptor
13 akt
14 single nucleotide polymorphism
15 dopamine receptor
16 comt
17 d2 receptor gene
18 gene environment
19 d3 receptor gene
20 glutamate receptor
21 slc6a3
22 dopamine transporter density
23 drd3
24 promoter polymorphism
25 darpp-32
26 drd2 gene
27 serotonin transporter gene
28 5-ht2a
29 genome wide
30 drd2
31 5-ht1a
32 dinucleotide repeat
33 mao
34 transporter promoter
35 dopamine receptor gene
36 p300
37 candidate gene
38 monoamine oxidase b
39 gene promoter polymorphism
40 catechol o-methyltransferase
41 hypocretin
42 receptor gene
43 cdna
44 monoamine oxidase
45 microsatellite
46 gene promoter
47 promoter region polymorphism
48 tyrosine hydroxylase
49 tic
50 intron
51 fmr1
52 d5 receptor gene
53 signal regulated kinase
54 glycogen synthase
55 sonic hedgehog
56 nr4a2
57 eralpha
58 dopa decarboxylase
59 tyrosine kinase
60 receptor drd4 gene
61 exon
62 mri
63 d3 receptor
64 catechol o-methyltransferase gene
65 pet
66 neurotrophic factor gene
67 nurr1
68 dopa
69 cb1
70 exon repeat polymorphism
71 twin
72 fdg
73 epilepsy
74 transporter gene slc6a3
75 c fos
76 fmr1 gene
77 allele
78 intronic polymorphism
79 rem
80 pacap
81 hydroxylase gene
82 tyrosine hydroxylase gene
83 microrna
84 drd1
85 essential tremor
86 leptin
87 ecd
88 grin2b
89 neurotrophin
90 gene slc6a3
91 gad65
92 d1 receptor gene
93 ltp
94 transporter
95 glycogen synthase kinase
96 fp
97 d4
98 ampa
99 immediate early gene
100 gene encoding
101 cyclin dependent kinase
102 tremor
103 gabaa
104 promoter region
105 promoter activity
106 park2
107 gene dopamine
108 d1
109 ssri
110 o-methyltransferase gene
111 myelin oligodendrocyte glycoprotein
112 gaba
113 allelic association
114 bdnf gene
115 transcription factor
116 htr2a
117 a1 allele
118 tsc2
119 ghrelin
120 d3
121 alzheimer disease
122 anxiety
123 meg
124 trh
125 trkb
126 p glycoprotein
127 enhancer
128 fosb
129 d2
130 tachykinin
131 p35
132 obesity
133 pde10a
134 3'-untranslated region
135 dystonia
136 alpha7
137 lobe
138 monoamine oxidase a
139 neuropeptide y
140 decarboxylase
141 gene association
142 trait
143 fat mass
144 snp
145 apolipoprotein e
146 parkinson disease
147 thyrotropin releasing hormone
148 hydrocephalus
149 gene transfer
150 intronic
151 lmx1b
152 dopamine beta hydroxylase
153 dopa decarboxylase gene
154 tryptophan hydroxylase
155 locus
156 ngf
157 blind
158 meta
159 5-ht
160 met
161 neurotrophin-3 gene
162 add
163 meningioma
164 pv
165 camp response element
166 factor gene
167 calmodulin
168 analysis gene
169 neurotensin
170 spatial learning
171 gene not
172 genome
173 rna binding
174 kinase
175 aav
176 sert
177 glur1
178 neuropeptide
179 cytochrome p450
180 dat gene
181 circling
182 cre
183 gene associated
184 adiposity
185 polymorphism 3'-untranslated region
186 igf i
187 fos
188 s100b
189 leg
190 pcr
191 functional promoter
192 mitochondrial
193 glucocorticoid receptor
194 ipt
195 beta hydroxylase gene
196 susceptibility gene
197 related gene
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