博文
帕金森症和多动症的基因知识发现
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科研思路来自科研实践、来自文献信息、来自同行交流。
科研思路和科研选题也可以来自知识发现，在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析，知识发现只提供非相关文献中的隐含知识概念，对于扩大科研人员的研究思路、进行科研选题很有意义，这些知识点可能对科研工作有所启发，获得新的科研视角和思路，但还需要科研人员进行科学验证。
知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
这里可以看到自1986年以来，国外情报专家的很多知识发现，被科研人员得到了证实。但我国的科研人员对知识发现的方法和应用不太熟悉，还没有很好地利用这种知识挖掘和信息分析的好方法。
知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=11546
最新研究进展
最近在《Journal of Clinical Investigation》杂志发表的一项研究表明，多巴胺信号和多巴胺转运蛋白功能的改变，与神经和精神疾病有关，包括早发性帕金森症和注意力缺陷多动症（ADHD）。生物通 www.ebiotrade.com
康奈尔大学威尔康奈尔医学院的博士后研究人员Michelle Sahai指出：“目前的研究结果，为进一步探索‘多巴胺功能障碍和多巴胺转运蛋白改变如何引起脑部疾病’提供了一个关键的基础。也有助于研究人员开发新的方法，来帮助数以百万计受这些疾病折磨的人。”
http://www.ebiotrade.com/newsf/read.asp?page=2014723112251426
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
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| A-query: attention deficit hyperactivity disorde... C-query: dopamine AND parkinsonism The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 32 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 259641 and can be accessed from the start page after you leave this session. There are 625 terms on the current B-list (197 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. |
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11399 B-terms ready on Wed Jul 23 22:53:20 2014
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
625 B-terms left after filter executed Wed Jul 23 23:11:10 2014
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dopamine transporter gene
B-list on Wed Jul 23 23:14:02 2014
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32 dinucleotide repeat
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34 transporter promoter
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38 monoamine oxidase b
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40 catechol o-methyltransferase
41 hypocretin
42 receptor gene
43 cdna
44 monoamine oxidase
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48 tyrosine hydroxylase
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50 intron
51 fmr1
52 d5 receptor gene
53 signal regulated kinase
54 glycogen synthase
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69 cb1
70 exon repeat polymorphism
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79 rem
80 pacap
81 hydroxylase gene
82 tyrosine hydroxylase gene
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89 neurotrophin
90 gene slc6a3
91 gad65
92 d1 receptor gene
93 ltp
94 transporter
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101 cyclin dependent kinase
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106 park2
107 gene dopamine
108 d1
109 ssri
110 o-methyltransferase gene
111 myelin oligodendrocyte glycoprotein
112 gaba
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114 bdnf gene
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119 ghrelin
120 d3
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122 anxiety
123 meg
124 trh
125 trkb
126 p glycoprotein
127 enhancer
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129 d2
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131 p35
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133 pde10a
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161 neurotrophin-3 gene
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173 rna binding
174 kinase
175 aav
176 sert
177 glur1
178 neuropeptide
179 cytochrome p450
180 dat gene
181 circling
182 cre
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184 adiposity
185 polymorphism 3'-untranslated region
186 igf i
187 fos
188 s100b
189 leg
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192 mitochondrial
193 glucocorticoid receptor
194 ipt
195 beta hydroxylase gene
196 susceptibility gene
197 related gene
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