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光遗传学（optogenetics）研究进展与信息分析报告

已有 4135 次阅读 2014-4-28 07:36 |个人分类:信息分析|系统分类:科研笔记

光遗传学，是研究人员使用一种新的光控方法选择并打开了某种生物的一类细胞。这也帮助科学家解答一个长期存在的难题，即关于脊髓中某类神经元的特殊功能的研究。光遗传学（optogenetics）——结合遗传工程与光来操作个别神经细胞的活性，发现脑部如何产生γ波（gamma oscillations），并为它们在调控脑部功能中的角色提供新证据，这将有助于发展一系列脑相关失调的新疗法。http://baike.baidu.com/link?url=WOZcxAA5QbnKZqB22s--omjA1lGR0-dFSM3MSm4oi0oiUo95uRCLgfcUzsxgFCJIkoMTyLrmodK1lF0mbAjWUq

Nature：发明光遗传学和CLARITY的技术达人

Karl Deisseroth一次又一次地用他发明的新技术在脑科学（brain science）发展史上刻下了自己的大名。

Karl Deisseroth在2004年有了第一个完全属于他的实验室，后来他发现那间实验室的前主人竟然是诺贝尔物理学奖得主朱棣文（Steven Chu）。“我搬进实验室的时候，朱棣文的名字还挂在实验室的门上。”美国加利福尼亚州斯坦福大学（Stanford University in California）的神经科学家Deisseroth回忆说。沾名人的光总是有好处的，后来有一位化学系的学生Feng Zhang拜访朱棣文时，Deisseroth居然用尽花言巧语把他给留了下来，“虽然Zhang没听说过我，可是我让他对我的课题产生了兴趣。” Deisseroth得意地说道。

http://www.bio360.net/news/show/6167.html

Science：光遗传学之父Deisseroth再发突破性成果

2005 年，斯坦福科学家 Karl Deisseroth 发明了光遗传学技术，他在细菌视蛋白的帮助下用光控制了大脑细胞的开/关。自那以后，世界各地的研究者们用这一技术对多种受电信号调节的细胞进行了研究，例如神经细胞、心脏细胞、干细胞等等。这里的电信号是指离子的跨膜流动。

光遗传学技术是在动物模型中深入理解生物系统的有力工具。但第一代光遗传学技术并不完美：兴奋性的光敏蛋白很有效，但抑制性视蛋白的效率很低。

现在， Deisseroth 的研究团队经过多年努力，重新设计了一种抑制性的光敏蛋白，大大提高了抑制性开关的工作效率。这将帮助研究者们更好的理解与行为、思维、情绪有关的大脑回路。相关研究论文刊登在了近期出版的《科学》（Science）杂志上。

http://www.bio360.net/news/show/9918.html

http://www.pubmedplus.cn/Pubmed/Statistic

信息分析结果

筛选或者

字段：作者全名

记录数

占%

01.Deisseroth Karl 58 篇8.644%

02.Augustine George J 8 篇1.192%

03.Tye Kay M 8 篇1.192%

04.Bamberg Ernst 6 篇0.894%

05.Lüthi Andreas 5 篇0.745%

06.Kokaia Merab 5 篇0.745%

07.Fukazawa Yugo 5 篇0.745%

08.Arenkiel Benjamin R 5 篇0.745%

09.Friedman Jeffrey M 4 篇0.596%

10.Dileone Ralph J 3 篇0.447%

11.Ledri Marco 3 篇0.447%

12.Land Benjamin B 3 篇0.447%

13.Anderson David J 3 篇0.447%

14.Arrenberg Aristides B 3 篇0.447%

15.Baier Herwig 3 篇0.447%

16.Domingos Ana I 2 篇0.298%

17.Ehrlich Ingrid 2 篇0.298%

18.Sordillo Aylesse 2 篇0.298%

19.Brayton Catherine E 2 篇0.298%

20.Kirik Deniz 2 篇

0.298

筛选或者

字段：机构

记录数

占%

01.stanford university 45 篇6.706%

02.university of california 40 篇5.961%

03.howard hughes medical institute 30 篇4.471%

04.massachusetts institute of technology 21 篇3.130%

05.virginia 17 篇2.534%

06.harvard medical school 13 篇1.937%

07.university college london 13 篇1.937%

08.stanford university school of medicine 12 篇1.788%

09.national institutes of health 9 篇1.341%

10.the university of tokyo 9 篇1.341%

11.harvard university 8 篇1.192%

12.university of virginia 8 篇1.192%

13.new york university 8 篇1.192%

14.university of pennsylvania 8 篇1.192%

15.duke university 8 篇1.192%

16.massachusetts general hospital 7 篇1.043%

17.national institute on drug abuse 7 篇1.043%

18.friedrich miescher institute for biomedical research 7 篇1.043%

19.brown university 6 篇0.894%

20.medical university of south carolina 6 篇0.894%

21.university of maryland school of medicine 6 篇0.894%

22.friedman brain institute 6 篇0.894%

23.stony brook university 5 篇0.745%

24.tohoku university graduate school of life sciences 5 篇0.745%

25.duke university medical center 5 篇0.745%

26.university of iowa 5 篇0.745%

27.columbia university 5 篇0.745%

28.california institute of technology 4 篇0.596%

29.lund university hospital 4 篇0.596%

30.the university of tokyo school of medicine 4 篇

0.596

筛选或者

字段：国家

记录数

占%

01.美国 364 篇54.247%

02.德国 69 篇10.283%

03.日本 48 篇7.154%

04.英国 36 篇5.365%

05.法国 26 篇3.875%

06.加拿大 16 篇2.385%

07.瑞士 15 篇2.235%

08.瑞典 12 篇1.788%

09.中国大陆 12 篇1.788%

10.以色列 7 篇1.043%

11.荷兰 7 篇1.043%

12.意大利 7 篇1.043%

13.澳大利亚 6 篇0.894%

14.韩国 5 篇0.745%

15.新加坡 5 篇0.745%

16.比利时 3 篇0.447%

17.奥地利 3 篇0.447%

18.西班牙 3 篇0.447%

19.印度 2 篇0.298%

20.葡萄牙 2 篇0.298%

21.丹麦 1 篇0.149%

22.希腊 1 篇0.149%

23.土耳其 1 篇

0.149

筛选或者

字段：中国省份

记录数

占%

01.上海市 4 篇0.596%

02.北京市 3 篇0.447%

03.重庆市 2 篇0.298%

04.吉林省 1 篇0.149%

05.湖南省 1 篇0.149%

06.广东省 1 篇0.149%

07.湖北省 1 篇

0.149

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字段：副主题词搭配

记录数

占%

01.Genetic Techniques* 351 篇52.310%

02.Neurons/physiology 263 篇39.195%

03.Brain/physiology 220 篇32.787%

04.Opsins/physiology 165 篇24.590%

05.Rhodopsin/physiology 138 篇20.566%

06.Opsins/genetics 122 篇18.182%

07.Light* 113 篇16.841%

08.Rhodopsin/genetics 103 篇15.350%

09.Optogenetics/methods 103 篇15.350%

10.Photic Stimulation* 100 篇14.903%

11.Cerebral Cortex/physiology 100 篇14.903%

12.Opsins/metabolism 93 篇13.860%

13.Neurons/metabolism 80 篇11.923%

14.Rhodopsin/metabolism 80 篇11.923%

15.Neural Pathways/physiology 76 篇11.326%

16.Luminescent Proteins/genetics 59 篇8.793%

17.Action Potentials/physiology 50 篇7.452%

18.Brain/metabolism 45 篇6.706%

19.Genetic Engineering* 42 篇6.259%

20.Photic Stimulation/methods 41 篇6.110%

21.Luminescent Proteins/metabolism 39 篇5.812%

22.Nerve Net/physiology 38 篇5.663%

23.Neurons/cytology 34 篇5.067%

24.Behavior, Animal/physiology 31 篇4.620%

25.Nerve Tissue Proteins/genetics 31 篇4.620%

26.Nerve Tissue Proteins/metabolism 28 篇4.173%

27.Interneurons/physiology 28 篇4.173%

28.Neurons/radiation effects 24 篇3.577%

29.Ion Channels/genetics 24 篇3.577%

30.Optics and Photonics/methods 23 篇3.428%

31.Bacterial Proteins/genetics 20 篇2.981%

32.Genetic Engineering/methods 18 篇2.683%

33.Ion Channels/metabolism 18 篇2.683%

34.Calcium/metabolism 16 篇2.385%

35.Mental Disorders/physiopathology 14 篇2.086%

36.Rhodopsin/chemistry 14 篇2.086%

37.Neurosciences/methods 13 篇1.937%

38.Caenorhabditis elegans/physiology 13 篇1.937%

39.Gene Expression Regulation/radiation effects 13 篇1.937%

40.Optics and Photonics/instrumentation 13 篇1.937%

41.Photic Stimulation/instrumentation 12 篇1.788%

42.Halorhodopsins/metabolism 12 篇1.788%

43.Synapses/metabolism 12 篇1.788%

44.Molecular Imaging/methods 10 篇1.490%

45.Image Processing, Computer-Assisted/methods 8 篇1.192%

46.Gene Targeting/methods 6 篇0.894%

47.Choline O-Acetyltransferase/metabolism 6 篇0.894%

48.Chlamydomonas/metabolism 6 篇0.894%

49.Light Signal Transduction/genetics 5 篇

0.745

筛选或者

字段：主题词与主题词

记录数

占%

01.主题词中同时含有"brain"与"neurons" 184 篇27.422%

02.主题词中同时含有"membrane potentials"与"neurons" 94 篇14.009%

03.主题词中同时含有"cerebral cortex"与"neurons" 87 篇12.966%

04.主题词中同时含有"brain"与"neural pathways" 74 篇11.028%

05.主题词中同时含有"action potentials"与"neurons" 58 篇8.644%

06.主题词中同时含有"action potentials"与"brain" 48 篇7.154%

07.主题词中同时含有"hippocampus"与"neurons" 42 篇6.259%

08.主题词中同时含有"neurons"与"synaptic transmission" 40 篇5.961%

09.主题词中同时含有"brain"与"nerve tissue proteins" 37 篇5.514%

10.主题词中同时含有"behavior, animal"与"neurons" 32 篇4.769%

11.主题词中同时含有"neurons"与"synapses" 30 篇4.471%

12.主题词中同时含有"brain"与"synapses" 28 篇4.173%

13.主题词中同时含有"cerebral cortex"与"prefrontal cortex" 27 篇4.024%

14.主题词中同时含有"gene expression regulation"与"neurons" 22 篇3.279%

15.主题词中同时含有"neural inhibition"与"synaptic transmission" 22 篇3.279%

16.主题词中同时含有"action potentials"与"neural pathways" 20 篇2.981%

17.主题词中同时含有"neurons"与"prefrontal cortex" 18 篇2.683%

18.主题词中同时含有"brain"与"mental disorders" 16 篇2.385%

19.主题词中同时含有"bacterial proteins"与"luminescent proteins" 15 篇2.235%

20.主题词中同时含有"excitatory postsynaptic potentials"与"synaptic transmission" 14 篇2.086%

21.主题词中同时含有"excitatory postsynaptic potentials"与"neurons" 13 篇1.937%

22.主题词中同时含有"interneurons"与"neural pathways" 11 篇1.639%

23.主题词中同时含有"action potentials"与"nerve net" 11 篇1.639%

24.主题词中同时含有"neural pathways"与"synapses" 10 篇1.490%

25.主题词中同时含有"action potentials"与"neural inhibition" 10 篇1.490%

26.主题词中同时含有"dependovirus"与"genetic vectors" 9 篇1.341%

27.主题词中同时含有"nerve tissue proteins"与"synapses" 8 篇1.192%

28.主题词中同时含有"action potentials"与"synaptic transmission" 8 篇1.192%

29.主题词中同时含有"excitatory postsynaptic potentials"与"neural pathways" 7 篇1.043%

30.主题词中同时含有"brain"与"image processing, computer-assisted" 7 篇

1.043

筛选或者

字段：年份

记录数

占%

01.2013 326 篇48.584%

02.2012 136 篇20.268%

03.2014 110 篇16.393%

04.2011 64 篇9.538%

05.2010 26 篇3.875%

06.2009 10 篇1.490%

07.2008 1 篇0.149%

08.2006 1 篇

0.149

筛选或者

字段：期刊

记录数

占%

01.J Neurosci 52 篇7.750%

02.Nat Neurosci 33 篇4.918%

03.PLoS One 27 篇4.024%

04.Neuron 26 篇3.875%

05.Nature 24 篇3.577%

06.Proc Natl Acad Sci U S A 22 篇3.279%

07.Conf Proc IEEE Eng Med Biol Soc 16 篇2.385%

08.Science 15 篇2.235%

09.Front Behav Neurosci 15 篇2.235%

10.Nat Methods 14 篇2.086%

11.Brain Res 14 篇2.086%

12.Front Mol Neurosci 13 篇1.937%

13.Curr Opin Neurobiol 11 篇1.639%

14.J Neurosci Methods 11 篇1.639%

15.J Neurophysiol 10 篇1.490%

16.Curr Biol 9 篇1.341%

17.J Neural Eng 9 篇1.341%

18.J Biol Chem 8 篇1.192%

19.Neuropharmacology 6 篇0.894%

20.Biol Psychiatry 6 篇0.894%

21.Behav Brain Res 6 篇0.894%

22.J Vis Exp 6 篇0.894%

23.Methods Mol Biol 6 篇0.894%

24.Cell 6 篇0.894%

25.Prog Brain Res 5 篇0.745%

26.Front Cell Neurosci 5 篇0.745%

27.Nat Protoc 5 篇0.745%

28.Opt Lett 4 篇0.596%

29.Exp Physiol 4 篇0.596%

30.J Mol Biol 4 篇0.596%

31.Cardiovasc Res 4 篇0.596%

32.Biochim Biophys Acta 4 篇0.596%

33.J Physiol 4 篇0.596%

34.Front Neurosci 4 篇0.596%

35.Sci Transl Med 4 篇0.596%

36.Nat Commun 4 篇0.596%

37.Biochem Soc Trans 3 篇0.447%

38.IEEE Trans Biomed Eng 3 篇0.447%

39.Front Pharmacol 3 篇0.447%

40.Philos Trans R Soc Lond B Biol Sci 3 篇0.447%

41.Int Rev Neurobiol 2 篇0.298%

42.Int J Neurosci 2 篇0.298%

43.Neurosci Bull 2 篇0.298%

44.Dev Growth Differ 2 篇0.298%

45.Mol Brain 2 篇0.298%

46.Nat Chem Biol 2 篇0.298%

47.Lab Chip 2 篇0.298%

48.Cell Rep 2 篇0.298%

49.J Am Chem Soc 2 篇0.298%

50.Neuroscience 2 篇

0.298

按被引次数排序时仅显示文献的前 1000 条

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. 谷歌翻译

Sohal VS. Zhang F. Yizhar O. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
来源: Nature ( P 0028-0836 E 1476-4687 ) IF:38.597 H指数:734 年: 2009 卷: 459 期: 7247 页: 698-702
PMID: 19396159 [Pubmed]

Optical deconstruction of parkinsonian neural circuitry. 谷歌翻译

Gradinaru V. Mogri M. Thompson KR. Henderson JM. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
来源: Science ( P 0036-8075 E 1095-9203 ) IF:31.027 H指数:711 年: 2009 卷: 324 期: 5925 页: 354-9
PMID: 19299587 [Pubmed]

Molecular and cellular approaches for diversifying and extending optogenetics. 谷歌翻译

Gradinaru V. Zhang F. Ramakrishnan C. Mattis J. Prakash R. Diester I. Goshen I. Thompson KR. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
来源: Cell ( P 0092-8674 E 1097-4172 ) IF:31.957 H指数:503 年: 2010 卷: 141 期: 1 页: 154-65
PMID: 20303157 [Pubmed]

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. 谷歌翻译

Zhang F. Gradinaru V. Adamantidis AR. Durand R. Airan RD. de Lecea L. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, California, USA.
来源: Nat Protoc ( P 1754-2189 E 1750-2799 ) IF:7.96 H指数:86 年: 2010 卷: 5 期: 3 页: 439-56
PMID: 20203662 [Pubmed]

Optogenetic dissection of a behavioural module in the vertebrate spinal cord. 谷歌翻译

Wyart C. Bene FD. Warp E. Scott EK. Trauner D. Baier H. Isacoff EY.
Helen Wills Neuroscience Institute and Department of Molecular and Cell Biology, University of California in Berkeley, Berkeley, California 94720, USA.
来源: Nature ( P 0028-0836 E 1476-4687 ) IF:38.597 H指数:734 年: 2009 卷: 461 期: 7262 页: 407-10
PMID: 19759620 [Pubmed]

Photoactivation of channelrhodopsin. 谷歌翻译

Ernst OP. Sánchez Murcia PA. Daldrop P. Tsunoda SP. Kateriya S. Hegemann P.
Institut für medizinische Physik und Biophysik, Charité-Universit?tsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. oliver.ernst@charite.de
来源: J Biol Chem ( P 0021-9258 E 1083-351X ) IF:4.651 H指数:363 年: 2008 卷: 283 期: 3 页: 1637-43
PMID: 17993465 [Pubmed]

Amygdala circuitry mediating reversible and bidirectional control of anxiety. 谷歌翻译

Tye KM. Prakash R. Kim SY. Fenno LE. Grosenick L. Zarabi H. Thompson KR. Gradinaru V. Ramakrishnan C. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
来源: Nature ( P 0028-0836 E 1476-4687 ) IF:38.597 H指数:734 年: 2011 卷: 471 期: 7338 页: 358-62
PMID: 21389985 [Pubmed]

The development and application of optogenetics. 谷歌翻译

Fenno L. Yizhar O. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
来源: Annu Rev Neurosci ( P 0147-006X E 1545-4126 ) IF:20.614 H指数:157 年: 2011 卷: 34 页: 389-412
PMID: 21692661 [Pubmed]

Optogenetics. Shining new light on neural circuits. 谷歌翻译

Miller G.
来源: Science ( P 0036-8075 E 1095-9203 ) IF:31.027 H指数:711 年: 2006 卷: 314 期: 5806 页: 1674-6
PMID: 17170269 [Pubmed]

10.

Optogenetics. 谷歌翻译

Deisseroth K.
Howard Hughes Medical Institute, Department of Bioengineering and Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. deissero@stanford.edu
来源: Nat Methods ( P 1548-7091 E 1548-7105 ) IF:23.565 H指数:112 年: 2011 卷: 8 期: 1 页: 26-9
PMID: 21191368 [Pubmed]

11.

Optogenetics in neural systems. 谷歌翻译

Yizhar O. Fenno LE. Davidson TJ. Mogri M. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
来源: Neuron ( P 0896-6273 E 1097-4199 ) IF:15.766 H指数:288 年: 2011 卷: 71 期: 1 页: 9-34
PMID: 21745635 [Pubmed]

12.

Conformational changes of channelrhodopsin-2. 谷歌翻译

Radu I. Bamann C. Nack M. Nagel G. Bamberg E. Heberle J.
Bielefeld University, Biophysical Chemistry, 33615 Bielefeld.
来源: J Am Chem Soc ( P 0002-7863 E 1520-5126 ) IF:10.677 H指数:322 年: 2009 卷: 131 期: 21 页: 7313-9
PMID: 19422231 [Pubmed]

13.

Optogenetic control of cardiac function. 谷歌翻译

Arrenberg AB. Stainier DY. Baier H. Huisken J.
Department of Physiology, University of California, San Francisco, CA 94158, USA.
来源: Science ( P 0036-8075 E 1095-9203 ) IF:31.027 H指数:711 年: 2010 卷: 330 期: 6006 页: 971-4
PMID: 21071670 [Pubmed]

14.

Cholinergic interneurons control local circuit activity and cocaine conditioning. 谷歌翻译

Witten IB. Lin SC. Brodsky M. Prakash R. Diester I. Anikeeva P. Gradinaru V. Ramakrishnan C. Deisseroth K.
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
来源: Science ( P 0036-8075 E 1095-9203 ) IF:31.027 H指数:711 年: 2010 卷: 330 期: 6011 页: 1677-81
PMID: 21164015 [Pubmed]

15.

Engineered photoreceptors as novel optogenetic tools. 谷歌翻译

Möglich A. Moffat K.
Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.
来源: Photochem Photobiol Sci ( P 1474-905X E 1474-9092 ) IF:2.923 H指数:49年: 2010 卷: 9 期: 10 页: 1286-300
PMID: 20835487 [Pubmed]

16.

Superresolution imaging of chemical synapses in the brain. 谷歌翻译

Dani A. Huang B. Bergan J. Dulac C. Zhuang X.
Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
来源: Neuron ( P 0896-6273 E 1097-4199 ) IF:15.766 H指数:288 年: 2010 卷: 68 期: 5 页: 843-56
PMID: 21144999 [Pubmed]

17.

Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. 谷歌翻译

Higley MJ. Sabatini BL.
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
来源: Nat Neurosci ( P 1097-6256 E 1546-1726 ) IF:15.251 H指数:241 年: 2010 卷: 13 期: 8 页: 958-66
PMID: 20601948 [Pubmed]

18.

An optogenetic toolbox designed for primates. 谷歌翻译

Diester I. Kaufman MT. Mogri M. Pashaie R. Goo W. Yizhar O. Ramakrishnan C. Deisseroth K. Shenoy KV.
Department of Bioengineering, Stanford University, Stanford, California, USA.
来源: Nat Neurosci ( P 1097-6256 E 1546-1726 ) IF:15.251 H指数:241 年: 2011 卷: 14 期: 3 页: 387-97
PMID: 21278729 [Pubmed]

19.

Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. 谷歌翻译

Zhu P. Narita Y. Bundschuh ST. Fajardo O. Schärer YP. Chattopadhyaya B. Bouldoires EA. Stepien AE. Deisseroth K. Arber S. Sprengel R. Rijli FM. Friedrich RW.
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation Basel, Switzerland.
来源: Front Neural Circuits ( P E 1662-5110 ) IF:3.333 H指数:2 年: 2009 卷: 3 页: 21
PMID: 20126518 [Pubmed]

20.

High-throughput study of synaptic transmission at the neuromuscular junction enabled by optogenetics and microfluidics.谷歌翻译

Stirman JN. Brauner M. Gottschalk A. Lu H.
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, USA.
来源: J Neurosci Methods ( P 0165-0270 E 1872-678X ) IF:2.114 H指数:81 年: 2010 卷: 191 期: 1 页: 90-3
PMID: 20538016 [Pubmed]

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