Fibronectin^EDA is an endogenous TLR4 ligand in scleroderma.

Dendritic cell targeting safely leads to integrated humoral and cellular immunity when combined with TLR agonists in cancer patients.

An orally available, shelf-stable pan-morbillivirus inhibitor targeting a viral polymerase effectively treats ferrets infected with a lethal dose of a measles-like virus.

U.S. national networks must set achievable modest goals and match them with reasonable resources in order to facilitate translational medicine projects.

Along with scientific and regulatory issues, the translation of cell and tissue therapies in the routine clinical practice needs to address standardization and cost-effectiveness through the definition of suitable manufacturing paradigms.

Targeting point mutations in mtDNA with antigenomic RNA restores normal mitochondrial function.

A newly discovered candidate gene for a devastating pediatric vascular disease encodes an aberrant form of adenosine deaminase 2, which creates an inflammatory environment.

The extracellular matrix can alter fibroblasts and affect the fibrogenic process that leads to disease.

The FDA-approved antihypertensive agent losartan prevents injury-induced epilepsy in rats by blocking pathogenic TGF-β signaling.