博文
肿瘤标志物热休克蛋白90α研究的信息分析与知识发现
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清华大学宣布，罗永章课题组在国际上首次发现热休克蛋白90α是全新肿瘤标志物，自主研发的定量检测试剂盒通过临床试验获准进入中国和欧盟市场。这是人热休克蛋白90α发现24年来首个获批用于临床产品，对提高病情监测和疗效评价水平、实现肿瘤个体化治疗具重要推动作用。
[视频]“热休克蛋白90α”的临床应用 用于癌症的病情监测和疗效评价http://news.cntv.cn/2013/11/17/VIDE1384667642137731.shtml
休克蛋白90α的最新相关新闻分析平台 http://www.pubmedplus.cn/
检索策略 HSP90α and cancer
分析结果
研究主题
0.893
0.893
0.893
知识发现结果
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| A-query: HSP90 C-query: cancer The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 2522 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 411 and can be accessed from the start page after you leave this session. There are 1170 terms on the current B-list (400 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. |
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
job id # 411 started Sun Nov 17 00:53:41 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: HSP90Sun Nov 17 00:53:47 2013
A query = HSP90 started Sun Nov 17 00:53:47 2013
A query resulted in 7209 titles
C_query_raw: HSP90 Sun Nov 17 00:54:07 2013
C: HSP90 7209
A: pubmed_query_A 7209
AC: ( HSP90 ) AND ( HSP90 ) 7209
C_query_raw: cancer Sun Nov 17 00:54:14 2013
C: cancer 2867702
A: pubmed_query_A 7209
AC: ( HSP90 ) AND ( cancer ) 2522
C_query_raw: cancer Sun Nov 17 00:54:19 2013
C: cancer 2867702
A: pubmed_query_A 7209
AC: ( HSP90 ) AND ( cancer ) 2522
C query = cancer started Sun Nov 17 00:54:19 2013
C query resulted in 50000 titles
A AND C query resulted in 2522 titles
11449 B-terms ready on Sun Nov 17 00:56:17 2013
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1170 B-terms left after filter executed Sun Nov 17 00:58:51 2013
B-list on Sun Nov 17 01:00:03 2013
1 mtor
2 jnk
3 akt
4 vegf
5 her2
6 stat3
7 cox-2
8 cyclin dependent kinase
9 casein kinase
10 pi3k
11 microrna
12 survivin
13 ki-67
14 nf kappab
15 jak2
16 toll receptor
17 grp94
18 adiponectin
19 hsc70
20 single nucleotide polymorphism
21 jak stat
22 bcl-2
23 progesterone receptor
24 bcr
25 chaperone
26 tyrosine kinase
27 cd14
28 cannabinoid receptor
29 mdm2
30 cyclin
31 caspase
32 bag3
33 topoisomerase
34 caspase-8
35 stat1
36 importin
37 histone deacetylase
38 grp78
39 mek1
40 ubiquitin conjugating enzyme
41 sp1
42 erk1
43 c jun n
44 ikappab
45 ubiquitin
46 sapk
47 transcription factor
48 herg
49 differentially expressed gene
50 wee1
51 calmodulin
52 caspase-3
53 atp binding
54 hsp70
55 helix loop helix
56 p53
57 calreticulin
58 response element
59 signal regulated kinase
60 autophagy
61 hdac6
62 glucocorticoid receptor
63 nod1
64 cyclophilin
65 hif-1
66 p38 mapk
67 nanog
68 toll
69 tnfalpha
70 c myc
71 stat5
72 hmlh1
73 clusterin
74 cdk2
75 bcl6
76 rankl
77 aromatase
78 cdk4
79 cftr
80 gstm1
81 kruppel factor
82 estrogen receptor alpha
83 eif4e
84 tlr4
85 pcr
86 estrogen receptor
87 raf-1
88 bdnf
89 gstt1
90 p53 tumor suppressor
91 vhl
92 mlh1
93 map kinase
94 polymorphism promoter
95 hdac
96 genome wide
97 quantitative trait loci
98 aquaporin
99 mmp-2
100 hsf1
101 chemokine
102 parkin
103 chop
104 c ebpalpha
105 glutathione s transferase
106 tak1
107 retinoic acid receptor
108 urocortin
109 lrrk2
110 chk1
111 dna binding
112 nf
113 chromatin remodeling
114 lck
115 nuclear localization signal
116 zinc finger protein
117 leukemia inhibitory factor
118 hiv
119 cadherin
120 socs3
121 statin
122 intron
123 cyp1a1
124 ccl20
125 receptor tyrosine kinase
126 thiopurine s methyltransferase
127 c jun
128 caldesmon
129 maspin
130 rack1
131 huntingtin
132 p tefb
133 ribosomal protein
134 sirt1
135 syk
136 caspase-2
137 cxcl8
138 oncogene
139 nf kappa b
140 aryl hydrocarbon receptor
141 rxr
142 erk5
143 receptor gene
144 ampk
145 mek
146 cbp p300
147 swi snf
148 bcr abl
149 ck2
150 importin alpha
151 vimentin
152 inos
153 gene helicobacter pylori
154 cdna
155 gene promoter
156 open reading frame
157 cdk9
158 jak
159 cullin
160 troponin
161 neurotrophin
162 ku
163 heat shock factor
164 pseudogene
165 reporter gene
166 kinesin
167 gsk3beta
168 ppargamma
169 gp120
170 bax
171 dnaj
172 at1
173 reading frame
174 matrix metalloproteinase
175 runx1
176 ppar gamma
177 egfr
178 cyclin d1
179 cdk6
180 heat shock protein
181 receptor kinase
182 smac
183 daxx
184 bhlh
185 erbb-2
186 epidermal growth factor
187 titin
188 transcriptional enhancer
189 related gene
190 ras
191 polyubiquitin gene
192 fk506
193 cytokine
194 nrf2
195 snorna
196 p38
197 erbb2
198 genome wide transcriptional
199 akt pkb
200 il-8
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