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原创,别转载。
科研思路来自科研实践、来自文献信息、来自同行交流。
科研思路和科研选题也可以来自知识发现,在我的博客“知识发现栏目”http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space有大量的科学研究知识发现的实例和分析,知识发现只提供非相关文献中的隐含知识概念,对于扩大科研人员的研究思路、进行科研选题很有意义,这些知识点可能对科研工作有所启发,获得新的科研视角和思路,但还需要科研人员进行科学验证。
知识发现与科学发现 http://blog.sciencenet.cn/blog-280034-713521.html
科学家发现乳腺癌的生物标志物P27
由哈佛干细胞研究所的Kornelia Polyak博士领衔的一个国际研究小组,解释了为什么二十出头就生育的女性为什么要比晚生育的女性,最终患上乳腺癌的几率小,这为解析乳腺癌致病机理,以及针对女性的癌症保护提出了新见解。 这一研究成果公布在Cell Stem Cell杂志上,并连续两个月入选了该期刊最受关注的文章。
这一研究组成员历经20年收集了上千份女性组织样品,分析一种乳腺祖细胞标记:p27在这些样品中的变化情况,这20年时间可以说囊括了女性最重要的一个阶段。研究人员通过大量实验,希望能弄清楚p27是否是一种精确的乳腺癌预测标签,Polyak博士表示,如果这个假说被证实,那么未来几个月内,就可以开发出针对乳腺癌风险的临床诊断试剂。
http://www.bio360.net/news/show/6637.html
知识发现如下:
A-query: Breast Cancer
C-query: p27
The B list contains title words and phrases (terms) that appeared in both the A and the C literature. 813 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 29675 and can be accessed from the start page after you leave this session. There are 1867 terms on the current B-list (发现43 个基因和蛋白质知识概念are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.
http://arrowsmith.psych.uic.edu/
job id # 30176 started Tue Aug 13 20:06:03 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Breast Cancer Tue Aug 13 20:06:18 2013
A_query_raw: Breast Cancer Tue Aug 13 20:06:18 2013
A query = Breast Cancer started Tue Aug 13 20:06:18 2013
A query = Breast Cancer started Tue Aug 13 20:06:18 2013
A query resulted in 50000 titles
C_query_raw: Breast Cancer Tue Aug 13 20:06:21 2013
C: Breast Cancer 266203
A: pubmed_query_A 266203
AC: ( Breast Cancer ) AND ( Breast Cancer ) 266203
C_query_raw: p27 Tue Aug 13 20:06:33 2013
C: p27 9405
A: pubmed_query_A 266203
AC: ( Breast Cancer ) AND ( p27 ) 813
C_query_raw: p27 Tue Aug 13 20:06:36 2013
C: p27 9405
A: pubmed_query_A 266203
AC: ( Breast Cancer ) AND ( p27 ) 813
C query = p27 started Tue Aug 13 20:06:36 2013
C query resulted in 9405 titles
A AND C query resulted in 813 titles
20203 B-terms ready on Tue Aug 13 20:06:59 2013
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1867 B-terms left after filter executed Tue Aug 13 20:14:18 2013
B-list on Tue Aug 13 20:15:39 2013
1 brca2
2 brca1
3 jnk
4 akt
5 vegf
6 adiponectin
7 mtor
8 stat3
9 mdm2
10 beta catenin
11 cyclin e
12 her-2 neu
13 fdg
14 her2
15 cyclin dependent kinase
16 tp53
17 pi3k
18 cxcr4
19 pten
20 her-2
21 estrogen receptor beta
22 estrogen receptor alpha
23 leptin
24 microrna
25 cip1
26 cdk2
27 promoter hypermethylation
28 cyclin d1
29 sp1
30 e2f
31 skp2
32 target rapamycin
33 rassf1a
34 e cadherin
35 cox-2
36 smad3
37 c myc
38 toll receptor
39 chek2
40 jnk1
41 rankl
42 ki-67
43 c met
知识发现实例
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