中国疾病预防控制中心等处的研究人员发表了题为“Human Infection with a Novel Avian-Origin Influenza A 7(H7N9) Virus”的文章，通过分离得到的3个H7N9样品，解析了这种新出现的禽流感病毒在感染人体后发生的病毒学变化，以及相关的流行病学分析，并且指出这3个样品中有6个内基因来自禽流感A (H9N2)病毒，这与此前南科大的成果相互佐证。
       这一研究成果公布在著名的医学期刊《新英格兰医学杂志》上，文章的通讯作者为中国疾病预防控制中心病毒病预防与控制研究所舒跃龙研究员，以及复旦大学袁正宏教授。
       关于新出现的人感染禽流感H7N9，4月14日国家卫生和计划生育委员会通报，全国报告新增人感染H7N9禽流感确诊病例11例，新增死亡病例2例。虽然目前针对该种病毒展开了多项研究，不过新型H7N9禽流感病毒还会在什么时间，什么地点以及如何出现，仍没有科学的证据和解释。

http://www.ebiotrade.com/newsf/2013-4/2013415112800739.htm

TI  - Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus.
AB  - Background Infection of poultry with influenza A subtype H7 viruses occurs
    worldwide, but the introduction of this subtype to humans in Asia has not been
    observed previously. In March 2013, three urban residents of Shanghai or Anhui,
    China, presented with rapidly progressing lower respiratory tract infections and
    were found to be infected with a novel reassortant avian-origin influenza A
    (H7N9) virus. Methods We obtained and analyzed clinical, epidemiologic, and
    virologic data from these patients. Respiratory specimens were tested for
    influenza and other respiratory viruses by means of real-time
    reverse-transcriptase-polymerase-chain-reaction assays, viral culturing, and
    sequence analyses. Results A novel reassortant avian-origin influenza A (H7N9)
    virus was isolated from respiratory specimens obtained from all three patients
    and was identified as H7N9. Sequencing analyses revealed that all the genes from
    these three viruses were of avian origin, with six internal genes from avian
    influenza A (H9N2) viruses. Substitution Q226L (H3 numbering) at the 210-loop in
    the hemagglutinin (HA) gene was found in the A/Anhui/1/2013 and A/Shanghai/2/2013
    virus but not in the A/Shanghai/1/2013 virus. A T160A mutation was identified at
    the 150-loop in the HA gene of all three viruses. A deletion of five amino acids
    in the neuraminidase (NA) stalk region was found in all three viruses. All three
    patients presented with fever, cough, and dyspnea. Two of the patients had a
    history of recent exposure to poultry. Chest radiography revealed diffuse
    opacities and consolidation. Complications included acute respiratory distress
    syndrome and multiorgan failure. All three patients died. Conclusions Novel
    reassortant H7N9 viruses were associated with severe and fatal respiratory
    disease in three patients. (Funded by the National Basic Research Program of
    China and others.).
AD  - The authors' affiliations are listed in the Appendix.
FAU - Gao, Rongbao
AU  - Gao R
FAU - Cao, Bin
AU  - Cao B
FAU - Hu, Yunwen
AU  - Hu Y
FAU - Feng, Zijian
AU  - Feng Z
FAU - Wang, Dayan
AU  - Wang D
FAU - Hu, Wanfu
AU  - Hu W
FAU - Chen, Jian
AU  - Chen J
FAU - Jie, Zhijun
AU  - Jie Z
FAU - Qiu, Haibo
AU  - Qiu H
FAU - Xu, Ke
AU  - Xu K
FAU - Xu, Xuewei
AU  - Xu X
FAU - Lu, Hongzhou
AU  - Lu H
FAU - Zhu, Wenfei
AU  - Zhu W
FAU - Gao, Zhancheng
AU  - Gao Z
FAU - Xiang, Nijuan
AU  - Xiang N
FAU - Shen, Yinzhong
AU  - Shen Y
FAU - He, Zebao
AU  - He Z
FAU - Gu, Yong
AU  - Gu Y
FAU - Zhang, Zhiyong
AU  - Zhang Z
FAU - Yang, Yi
AU  - Yang Y
FAU - Zhao, Xiang
AU  - Zhao X
FAU - Zhou, Lei
AU  - Zhou L
FAU - Li, Xiaodan
AU  - Li X
FAU - Zou, Shumei
AU  - Zou S
FAU - Zhang, Ye
AU  - Zhang Y
FAU - Li, Xiyan
AU  - Li X
FAU - Yang, Lei
AU  - Yang L
FAU - Guo, Junfeng
AU  - Guo J
FAU - Dong, Jie
AU  - Dong J
FAU - Li, Qun
AU  - Li Q
FAU - Dong, Libo
AU  - Dong L
FAU - Zhu, Yun
AU  - Zhu Y
FAU - Bai, Tian
AU  - Bai T
FAU - Wang, Shiwen
AU  - Wang S
FAU - Hao, Pei
AU  - Hao P
FAU - Yang, Weizhong
AU  - Yang W
FAU - Zhang, Yanping
AU  - Zhang Y
FAU - Han, Jun
AU  - Han J
FAU - Yu, Hongjie
AU  - Yu H
FAU - Li, Dexin
AU  - Li D
FAU - Gao, George F
AU  - Gao GF
FAU - Wu, Guizhen
AU  - Wu G
FAU - Wang, Yu
AU  - Wang Y
FAU - Yuan, Zhenghong
AU  - Yuan Z
FAU - Shu, Yuelong
AU  - Shu Y
LA  - ENG
PT  - JOURNAL ARTICLE
DEP - 20130411
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
EDAT- 2013/04/13 06:00
MHDA- 2013/04/13 06:00
CRDT- 2013/04/13 06:00
AID - 10.1056/NEJMoa1304459 [doi]
PST - aheadofprint
SO  - N Engl J Med. 2013 Apr 11.

PMID- 23571744
OWN - NLM
STAT- In-Data-Review
DA  - 20130410
IS  - 1756-1833 (Electronic)
IS  - 0959-535X (Linking)
VI  - 346
DP  - 2013