John B. Gurdon和Shinya Yamanaka在“体细胞可以经重编程后转化为可诱导的多能干细胞”的研究发现最终赢得了诺贝尔医学生物学专家委员会的肯定与认可,共同成为2012年诺贝尔医学奖的获奖者。
最后,感谢John B. Gurdon和Shinya Yamanaka在生物医学领域做出的贡献。
John B. Gurdon 因1962年的开创性工作而获奖,这一年他29岁。
Gurdon, J.B. (1962). The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. Journal of Embryology and Experimental Morphology 10:622-640.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
19
9.896 %
DEVELOPMENT
17
8.854 %
CELL
12
6.250 %
DEVELOPMENTAL BIOLOGY
11
5.729 %
JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY
9
4.688 %
CIBA FOUNDATION SYMPOSIA
8
4.167 %
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
8
4.167 %
EMBO JOURNAL
7
3.646 %
CURRENT BIOLOGY
5
2.604 %
JOURNAL OF MOLECULAR BIOLOGY
5
2.604 %
CELL CYCLE
4
2.083 %
MECHANISMS OF DEVELOPMENT
4
2.083 %
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
3
1.563 %
GENES DEVELOPMENT
3
1.563 %
JOURNAL OF CELLULAR BIOCHEMISTRY
3
1.563 %
NATURE CELL BIOLOGY
3
1.563 %
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B BIOLOGICAL SCIENCES
3
1.563 %
PROCEEDINGS OF THE ROYAL SOCIETY B BIOLOGICAL SCIENCES
3
1.563 %
SEMINARS IN CELL DEVELOPMENTAL BIOLOGY
3
1.563 %
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
2
1.042 %
BIOESSAYS
2
1.042 %
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III SCIENCES DE LA VIE LIFE SCIENCES
2
1.042 %
DIFFERENTIATION
2
1.042 %
JOURNAL OF CELL BIOLOGY
2
1.042 %
METHODS
2
1.042 %
METHODS IN CELL BIOLOGY
2
1.042 %
字段: Web of Science 类别
记录 计数
%,共 192
柱状图
表格中显示的数据行 所有数据行
DEVELOPMENTAL BIOLOGY
62
32.292 %
CELL BIOLOGY
58
30.208 %
BIOCHEMISTRY MOLECULAR BIOLOGY
46
23.958 %
MULTIDISCIPLINARY SCIENCES
43
22.396 %
BIOLOGY
15
7.813 %
ANATOMY MORPHOLOGY
10
5.208 %
MEDICINE GENERAL INTERNAL
9
4.688 %
GENETICS HEREDITY
7
3.646 %
BIOCHEMICAL RESEARCH METHODS
3
1.563 %
ECOLOGY
3
1.563 %
EVOLUTIONARY BIOLOGY
3
1.563 %
BIOPHYSICS
2
1.042 %
Shinya Yamanaka 的开创性工作是在2006年44岁时完成,被引6212次。
Takahashi, K., Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent ...
…, M Narita, T Ichisaka, K Tomoda, S Yamanaka - cell, 2007 - repository.kulib.kyoto-u.ac.jp
抄録: Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient-and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from ...
K Okita, T Ichisaka, S Yamanaka - Nature, 2007 - nature.com
Abstract We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) expression. These induced ...
…, K Okita, Y Mochiduki, N Takizawa, S Yamanaka - Nature …, 2007 - nature.com
Abstract Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouse fibroblasts by retroviral transduction of four transcription factors: ...
…, M Nakagawa, H Hyenjong, T Ichisaka, S Yamanaka - Science, 2008 - sciencemag.org
Abstract Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by introducing Oct3/4 and Sox2 with either Klf4 and c-Myc or Nanog and Lin28 using retroviruses or lentiviruses. Patient-specific iPS cells could be useful in drug ...
…, K Okita, K Takahashi, T Chiba, S Yamanaka - Science …, 2008 - stke.sciencemag.org
Abstract: Induced pluripotent stem (iPS) cells have been generated from mouse and human fibroblasts by the retroviral transduction of four transcription factors. However, the cell origins and molecular mechanisms of iPS cell induction remain elusive. This report describes the ...
Generating pluripotent stem cells directly from cells obtained from patients is one of the ultimate goals in regenerative medicine. Two “reprogramming” strategies for the generation of pluripotent stem cells from somatic cells have been studied extensively: nuclear transfer ...
…, K Takahashi, M Maruyama, M Maeda, S Yamanaka - cell, 2003 - ccsu.edu
... These data indicate analyses demonstrated that nanog is expressed in ES cells, but not in neural or hematopoietic stemcells (Ra- ... Positions of the probe and ScaI recognition sites (S) used for Southern blot were shown. ... scribed (Yamanaka et al., 2000, 1998). ...
K Takahashi, K Okita, M Nakagawa, S Yamanaka - Nature protocols, 2007 - nature.com
Abstract Clinical application of embryonic stem (ES) cells faces difficulties regarding use of embryos, as well as tissue rejection after implantation. One way to circumvent these issues is to generate pluripotent stem cells directly from somatic cells. Somatic cells can be ...
K Takahashi, K Mitsui, S Yamanaka - Nature, 2003 - nature.com
Abstract Embryonic stem (ES) cells are pluripotent cells derived from early mammalian embryos 1, 2. Their immortality and rapid growth make them attractive sources for stem cell therapies 3; however, they produce tumours (teratomas) when transplanted, which could ...