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雷帕霉素与肥胖研究的知识发现

已有 5271 次阅读 2012-8-10 14:57 |个人分类:知识发现|系统分类:科研笔记| 知识, normal, 肥胖, 下丘脑

原创博文,不许转载。
 
知识发现与数据挖掘的关系

http://blog.sciencenet.cn/blog-280034-600896.html

 
最新研究动态:
 
Rapamycin(雷帕霉素)能减轻年龄相关肥胖症状,这一过程与下丘脑前阿黑皮素原神经元中mTOR信号增加有关。
 
雷帕霉素(Rapamycin)最先是从东南太平洋上的一个小岛——复活岛的土壤样本中发现的一种细菌产生,自20世纪70年代开发出来便经常作为免疫抑制剂用于器官移植,以减缓器官移植手术后的免疫排斥反应,特别是肾移植。
 
检索策略:
 
A-query: Rapamycin 
C-query: Obesity
 

知识发现结果:

 

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 236articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 11025 and can be accessed from the start page after you leave this session. There are 1399 terms on the current B-list (雷帕霉素与肥胖研究的知识发现249个与基因相关知识概念,对科研选题与进行中的科研工作有一定参考价值 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 
知识发现平台:
 
 
mTOR信号通路是调控细胞生长与增殖的一个关键通路,该通路将从营养分子、能量状态以及生长因子传来的信号整合在一起,调控大量的生命过程,包括自我吞噬、核糖体的生物组合和代谢等。该通路的失调与多种人类疾病相关,包括癌症、糖尿病与心血管疾病。
 
Start A-Literature C-Literature B-list Filter Literature
AB literature

B-term

BC literature

Rapamycin mtor Obesity
1: The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas. 2012
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2: Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2. 2012
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3: Insulin-induced mTOR activity exhibits anti-hepatitis C virus activity. 2012
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4: Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo. 2012
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5: mTOR-rictor is the Ser(473) kinase for AKT1 in mouse one-cell stage embryos. 2012
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6: The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. 2012
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7: Current development of the second generation ofmTOR inhibitors as anticancer agents. 2012
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8: CYR61 controls p53 and NF-kappaB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian cancer cells. 2012
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9: Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107). 2012
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10: Biochemical and pharmacological inhibition ofmTOR by rapamycin and an ATP-competitivemTOR inhibitor. 2012
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11: mTOR activity under hypoxia. 2012
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12: Isolation of the mTOR complexes by affinity purification. 2012
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13: Detection of cytoplasmic and nuclear functions of mTOR by fractionation. 2012
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14: Evaluation of mTOR-regulated mRNA translation. 2012
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15: Quantitative visualization of autophagy induction by mTOR inhibitors. 2012
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16: Expanding human T regulatory cells with themTOR-inhibitor rapamycin. 2012
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17: Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells. 2012
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18: Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes. 2012
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19: Evaluating the therapeutic potential of mTORinhibitors using mouse genetics. 2012
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20: Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors. 2012
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21: Assessing the function of mTOR in human embryonic stem cells. 2012
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22: Development of ATP-competitive mTORinhibitors. 2012
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23: mTOR inhibitor-associated proteinuria in kidney transplant recipients. 2012
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24: Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. 2012
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25: The role of mTOR signaling in Alzheimer disease. 2012
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26: mTOR as a Target of Everolimus in Refractory/Relapsed Hodgkin Lymphoma. 2012
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27: Kinome-wide selectivity profiling of ATP-competitive mTOR (mammalian target ofrapamycin) inhibitors and characterization of their binding kinetics. 2012
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28: Analysis of the pharmacodynamic activity of themTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial. 2012
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29: Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat. 2012
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30: Immunohistochemical analysis of the mTORpathway in intrahepatic cholangiocarcinoma. 2012
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31: miR-376b controls starvation and mTORinhibition-related autophagy by targeting ATG4C and BECN1. 2012
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32: A Novel Application of Topical RapamycinFormulation, an Inhibitor of mTOR, for Patients With Hypomelanotic Macules in Tuberous Sclerosis Complex. 2012
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33: Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury. 2012
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34: HIV-1 Promotes Renal Tubular Epithelial Cell Protein Synthesis: Role of mTOR Pathway. 2012
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35: Roles of the mammalian target of rapamycin,mTOR, in controlling ribosome biogenesis and protein synthesis. 2012
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36: mTOR inhibitors in cancer therapy. 2012
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37: mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors. 2012
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38: The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) pathways in the dorsal hippocampus. 2012
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39: Drug Interaction Between Cyclosporine andmTOR Inhibitors in Experimental Model of Chronic Cyclosporine Nephrotoxicity and Pancreatic Islet Dysfunction. 2012
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40: Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with Fragile X syndrome. 2012
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41: AKT/mTOR activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis. 2012
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42: PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations. 2012
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43: Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation. 2012
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44: Mycobacterial induction of autophagy varies by species and occurs independently of mTORinhibition. 2012
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45: Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes. 2012
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46: mTOR Inhibitors and its Role in the Treatment of Head and Neck Squamous Cell Carcinoma. 2012
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47: Sustained antitumor activity by co-targetingmTOR and the microtubule with temsirolimus/vinblastine combination in hepatocellular carcinoma. 2012
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48: Deregulated mTOR-mediated translation in intellectual disability. 2012
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49: Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism. 2012
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50: [(11)C]GSK2126458 and [(18)F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers. 2012
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51: Isoleucine and Leucine Independently RegulatemTOR Signaling and Protein Synthesis in MAC-T Cells and Bovine Mammary Tissue Slices. 2012
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52: The PI3-Kinase/mTOR-Targeting Drug NVP-BEZ235 Inhibits Growth and IgE-Dependent Activation of Human Mast Cells and Basophils. 2012
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53: Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR. 2012
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54: Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor ofmTOR. 2012
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55: Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells. 2012
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56: Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTORcomplex 2 (mTORC2). 2012
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57: mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes. 2012
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58: Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma. 2012
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59: HER2+ Breast Cancer Therapy: By CPP-ZFN Mediated Targeting of mTOR? 2012
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60: Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells. 2012
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61: Akt Inhibitors MK-2206 and Nelfinavir overcomemTOR inhibitor resistance in DLBCL. 2012
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62: Dose-Dependent Effects of Sirolimus on mTORSignaling and Polycystic Kidney Disease. 2012
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63: Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression. 2012
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64: Critical role of arachidonic acid-activated mTORsignaling in breast carcinogenesis and angiogenesis. 2012
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65: Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. 2012
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66: PI3K and mTOR signaling pathways in cancer: new data on targeted therapies. 2012
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67: Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia. 2012
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68: Role of PRAS40 in Akt and mTOR signaling in health and disease. 2012
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69: Intestinal cell kinase (ICK) promotes activation ofmTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908. 2012
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70: Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors. 2012
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71: The translational landscape of mTOR signalling steers cancer initiation and metastasis. 2012
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72: Synergistic Effects of Erlotinib and Everolimus on Bronchial Carcinoids and Large-Cell Neuroendocrine Carcinomas with Activated EGFR/AKT/mTOR Pathway. 2012
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73: Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTORpathway and induction of autophagy. 2012
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74: Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model. 2012
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75: Biologic rationale and clinical activity of mTORinhibitors in gynecological cancer. 2012
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76: Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation. 2012
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77: CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. 2012
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78: Non-small cell lung carcinoma therapy usingmTOR-siRNA. 2012
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79: Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells. 2012
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80: Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells. 2012
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81: mTOR is required for asymmetric division through small GTPases in mouse oocytes. 2012
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82: The mTOR Signalling Pathway in Human Cancer. 2012
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83: mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas. 2012
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84: mTOR kinase inhibitors as a treatment strategy in hematological malignancies. 2012
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85: The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells. 2012
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86: PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTORinhibitors. 2012
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87: Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2-Deficient Target Cell Types. 2012
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88: Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTORpathway. 2012
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89: Delayed mTOR inhibition with low dose of everolimus reduces TGFbeta expression, attenuates proteinuria and renal damage in the renal mass reduction model. 2012
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90: Inhibition of MTOR disrupts autophagic flux in podocytes. 2012
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91: Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. 2012
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92: PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter. 2012
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93: InTERTesting association between telomerase,mTOR and phytochemicals. 2012
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94: A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. 2012
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95: Comparative efficacy of vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) and mammalian target of rapamycin (mTOR) inhibitor as second-line therapy in patients with metastatic renal cell carcinoma after the failure of first-line VEGF TKI. 2012
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96: Major involvement of mTOR in the PPARgamma-induced stimulation of adipose tissue lipid uptake and fat accretion. 2012
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97: Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts. 2012
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98: Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. 2012
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99: Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. 2012
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100: Targeting mTOR Pathways in Human Malignancies. 2012
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101: Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: Incidence, radiographic findings and correlation with clinical outcome. 2012
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102: Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR. 2012
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103: The role and regulation of mTOR in T-lymphocyte function. 2012
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104: A Role of the Mammalian Target of Rapamycin(mTOR) in Glutamate-Induced Down-regulation of Tuberous Sclerosis Complex Proteins 2 (TSC2). 2012
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105: Osmotic Stress Regulates Mammalian Target of Rapamycin (mTOR) Complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor Protein Phosphorylation. 2012
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106: An overview of the mTOR pathway as a target in cancer therapy. 2012
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107: mTOR-dependent modulation of gastric nesfatin-1/NUCB2. 2012
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108: Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells. 2012
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109: Regulation and function of mTOR signalling in T cell fate decisions. 2012
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110: mTOR signaling pathway and mTOR inhibitors in cancer therapy. 2012
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111: The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas. 2012
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112: Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. 2012
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113: Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels. 2012
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114: mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma. 2012
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115: Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy. 2012
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116: Ubiquitin Specific Peptidase 9, X-linked (USP9X) Modulates the Activity of Mammalian Target of Rapamycin (mTOR). 2012
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117: Inflammation-Driven Reprogramming of CD4(+)Foxp3(+) Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTORInhibition in vivo. 2012
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118: N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients. 2012
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119: mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma. 2012
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120: Simultaneous targeting of EGFR and mTORinhibits the growth of colorectal carcinoma cells. 2012
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121: mTOR inhibitors in the management of hormone receptor-positive breast cancer: the latest evidence and future directions. 2012
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122: The PP242 Mammalian Target of Rapamycin(mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance. 2012
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123: The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells. 2012
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124: Cardiac mTOR protects the heart against ischemia-reperfusion injury. 2012
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125: Clinicopathological correlations of mTOR and pAkt expression in non-small cell lung cancer. 2012
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126: Suppression of proinvasive RGS4 by mTORinhibition optimizes glioma treatment. 2012
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127: The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway. 2012
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128: AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells. 2012
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129: Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries. 2012
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130: Finding a better drug for epilepsy: The mTORpathway as an antiepileptogenic target. 2012
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131: Reduction of insulin signalling pathway IRS-1/IRS-2/AKT/mTOR and decrease of epithelial cell proliferation in the prostate of glucocorticoid-treated rats. 2012
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132: The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis. 2012
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133: Metformin and the mTOR Inhibitor Everolimus (RAD001) Sensitize Breast Cancer Cells to the Cytotoxic Effect of Chemotherapeutic Drugs In Vitro. 2012
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134: Tumor necrosis factor-alpha (TNF-alpha)-mediated in vitro human retinal pigment epithelial (RPE) cell migration mainly requires Akt/mTORcomplex 1 (mTORC1), but not mTOR complex 2(mTORC2) signaling. 2012
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135: Neuregulin Promotes Incomplete Autophagy of Prostate Cancer Cells That Is Independent of mTORPathway Inhibition. 2012
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136: The mTOR pathway is activated in glial cells in mesial temporal sclerosis. 2012
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137: Plasticity and mTOR: Towards Restoration of Impaired Synaptic Plasticity in mTOR-Related Neurogenetic Disorders. 2012
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138: Evidence of Ambiguous Differentiation andmTOR Pathway Dysregulation in Subependymal Giant Cell Astrocytoma. 2012
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139: Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic alpha 2A receptor through the mTOR pathway and its implication in new-onset diabetes in renal transplantation. 2012
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140: Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non-Small-Cell Lung Cancer. 2012
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141: Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels. 2012
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142: Alterations of the p53 and PIK3CA/AKT/mTORpathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics. 2012
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143: Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of rapamycin) in denervated atrophic and hypertrophic mouse skeletal muscle. 2012
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144: Genotype-Dependent Efficacy of a Dual PI3K/mTOR Inhibitor, NVP-BEZ235, and an mTORInhibitor, RAD001, in Endometrial Carcinomas. 2012
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145: Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition. 2012
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146: Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTORsignaling. 2012
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147: Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling. 2012
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148: Rapamycin Inhibits the mTOR/p70S6K Pathway and Attenuates Cardiac Fibrosis in Adriamycin-induced Dilated Cardiomyopathy. 2012
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149: Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation. 2012
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150: Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. 2012
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151: Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma. 2012
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152: The mTOR-inhibitor Rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response. 2012
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153: Nuclear factor of activated T-cells (NFAT) c3 inhibition of mTOR signaling through induction of REDD1 in human intestinal cells. 2012
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154: Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment: Chemoprevention with Rapamycin, an mTOR Inhibitor and Anti-Aging Drug. 2012
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155: Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells. 2012
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156: Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3beta signaling pathways. 2012
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157: Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma. 2012
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158: Activated mTOR/P70S6K signaling pathway is involved in insulinoma tumorigenesis. 2012
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159: Lymphedema of the Breast as a Symptom of Internal Diseases or Side Effect of mTorInhibitors. 2012
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160: Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. 2012
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161: L-Leucine improves anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q)MDS by activating the mTORpathway. 2012
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162: Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways. 2012
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163: Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application. 2012
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164: Chronic inhibition of mTOR by rapamycinmodulates cognitive and non-cognitive components of behavior throughout lifespan in mice. 2012
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165: [Remission of an iatrogenic Kaposi sarcoma in a patient with myasthenia gravis after switching immunosuppressive therapy to the mTOR inhibitor everolimus]. 2012
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166: Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy. 2012
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167: mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis. 2012
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168: Identification of Akt-Independent Regulation of Hepatic Lipogenesis by Mammalian Target ofRapamycin (mTOR) Complex 2. 2012
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169: Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History. 2012
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170: Management of Metabolic Effects Associated With Anticancer Agents Targeting the PI3K-Akt-mTOR Pathway. 2012
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171: Resistance to the mTOR-inhibitor RAD001 elevates integrin alpha2- and beta1-triggered motility, migration and invasion of prostate cancer cells. 2012
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172: Response to Comment on"A Dynamic Network Model of mTOR Signaling Reveals TSC-IndependentmTORC2 Regulation": Building a Model of themTOR Signaling Network with a Potentially Faulty Tool. 2012
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173: Immunohistochemical Analysis of the Akt/mTOR/4E-BP1 Signalling Pathway in Canine Haemangiomas and Haemangiosarcomas. 2012
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174: Altered LKB1/AMPK/TSC1/TSC2/mTORsignaling causes disruption of Sertoli cell polarity and spermatogenesis. 2012
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175: Identification of mammalian target ofrapamycin (mTOR) as a direct target of fenretinib both in vitro and in vivo. 2012
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176: Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype. 2012
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177: Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. 2012
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178: Glutamate transporter-dependent mTORphosphorylation in Muller glia cells. 2012
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179: Dual targeting of mTOR and Aurora-A kinase for the treatment of uterine leiomyosarcoma. 2012
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180: The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis. 2012
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181: Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML under conditions mimicking the bone marrow microenvironment. 2012
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182: Constitutive activation of the mTOR signaling pathway within the normal glomerulus. 2012
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183: EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas. 2012
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184: Disrupting the mTOR signaling network as a potential strategy for the enhancement of cancer radiotherapy. 2012
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185: Perspectives on mTOR Inhibitors for Castration-Refractory Prostate Cancer. 2012
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186: Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold. 2012
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187: IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. 2012
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188: PI3K/mTOR Signaling Pathways in Medulloblastoma. 2012
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189: Targeting the PI3K/AKT/mTOR Signaling Axis in Children with Hematologic Malignancies. 2012
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190: N-Carbamylglutamate Enhances Pregnancy Outcome in Rats through Activation of the PI3K/PKB/mTOR Signaling Pathway. 2012
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191: Hepatitis B Virus X Protein Upregulates mTORSignaling through IKKbeta to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma. 2012
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192: Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically-defined head and neck squamous cell carcinoma mouse model. 2012
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193: Pharmacological targeting of mammalian target of rapamycin (mTOR) inhibits ovarian granulosa cell tumor growth. 2012
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194: New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs). 2011
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195: The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated byrapamycin. 2011
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196: Activation of mTOR and RhoA is a major 

 

 

 


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