Understanding oncogenesis at the molecular level offers the prospect of tailoring treatments much more precisely for patients with advanced cases of this deadliest of skin cancers.
By Keith T. Flaherty

An Aspirin for Your Cancer?
Can cancer—which can originate from, and often resemble, chronically inflamed tissue—be curtailed using familiar anti-inflammatory agents, without the side effects?
By Giorgio Trinchieri

The Movement of Goods Around the Cell
A biologist and a physicist collaborate on a decade-long exploration of the physical parameters of membrane traffic in eukaryotic cells.
By Patricia Bassereau and Bruno Goud

EDITORIAL

The “Me Decade”
of Cancer
Drugs that target specific tumors are harbingers of a new era of genetically informed medicine.
By Sarah Greene

CRITIC AT LARGE

Imagining a Cure
For some cancer patients, close is not good enough
By Nicholas P. Restifo and Megan Bachinski

THOUGHT EXPERIMENT

Medical Publishing for an N of One
New technologies and mind-sets required for information delivery in the age of genomics.
By George D. Lundberg

NOTEBOOK

An F1000 Hidden Jewel:
Taking Shape
A plant biologist borrows an engineering technique to study how flowers develop their unique architecture.
By Richard P. Grant

NOTEBOOK

Family Affair
In discovering their shared ancestry, a distantly-related animal geneticist and plant pathologist find a common thread in their work on immune receptors.
By Megan Scudellari

PROFILE

Harvesting Ideas
Joy Ward is reaping the rewards of her studies on how plants handle global climate change—gathering academic accolades and presidential embraces along the way.
By Karen Hopkin