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早老性痴呆症研究的信息分析与知识发现

已有 2226 次阅读 2011-1-3 12:28 |个人分类:知识发现|系统分类:论文交流| 知识发现, 信息分析, 早老性痴呆症

 alzheimers disease; solid-state nmr spectroscopy; in alzheimers disease; solid-state nmr; alzheimer disease; in alzheimers; nmr spectroscopy; amyloid fibrils; prion protein

http://www.gopubmed.org/web/gopubmed/1?WEB021m0ju08zulmI5I1I00h001000j100200010

382 documents semantically analyzed

 

 

 

 

 

 
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1 2 3 ...10 
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J Biol Chem
 
14
P Natl Acad Sci Usa
 
12
Acta Neuropathol
 
11
Prion
 
9
J Neurosci
 
9
Neurology
 
8
Nature
 
7
Science
 
6
Neurosci Lett
 
6
Brain Pathol
 
5
Curr Med Chem
 
5
Neurobiol Aging
 
5
Neurobiol Dis
 
5
Ann Neurol
 
5
Am J Pathol
 
5
Proc Natl Acad Sci U S A
 
4
Neuropathology
 
4
Curr Alzheimer Res
 
4
Trends Biochem Sci
 
4
Embo J
 
4
1 2 3 ...10 
 
1 2 3 ...121 
Top Terms
Publications
 
Alzheimer Disease
 
363
Prions
 
342
Humans
 
330
Proteins
 
309
Amyloid
 
209
Amyloid beta-Protein
 
195
Animals
 
192
Prion Diseases
 
174
Amyloid beta A4 protein
 
134
Peptides
 
120
Neurodegenerative Diseases
 
113
Neurons
 
104
Mice
 
93
Senile Plaques
 
88
Major prion protein
 
87
Brain
 
85
Creutzfeldt-Jakob Syndrome
 
83
Mutation
 
83
fibril
 
82
Patients
 
77
1 2 3 ...121 
 
1 2 3 ...66 
Top Authors
Publications
 
Beyreuther K
 
12
Kitamoto T
 
10
Tateishi J
 
10
Liberski P
 
9
Prusiner S
 
9
Tagliavini F
 
8
Bugiani O
 
7
Masters C
 
7
Ghetti B
 
6
Frangione B
 
6
Hooper N
 
5
Wisniewski T
 
5
Multhaup G
 
5
Cappai R
 
5
Soto C
 
5
Ironside J
 
5
Inestrosa N
 
4
Armstrong R
 
4
Hauw J
 
4
Sigurdsson E
 
4
1 2 3 ...66 

job id # 4643 started Mon Jan 3 00:05:56 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
4643 Search ARROWSMITH A
A_query_raw: alzheimers disease AND amyloid fibrils AND prion proteinMon Jan 3 00:06:21 2011

A query = alzheimers disease AND amyloid fibrils AND prion protein started Mon Jan 3 00:06:21 2011
A query resulted in 382 titles
4643 Search ARROWSMITH C
C_query_raw: nmr spectroscopy Mon Jan 3 00:07:01 2011

C: nmr spectroscopy 166940

A: pubmed_query_A 382

AC: ( alzheimers disease AND amyloid fibrils AND prion protein ) AND ( nmr spectroscopy ) 10

C query = nmr spectroscopy started Mon Jan 3 00:07:03 2011
C query resulted in 50000 titles
A AND C query resulted in 10 titles
1532 B-terms ready on Mon Jan 3 00:09:30 2011

 

 

 

B-list on Mon Jan 3 00:11:14 2011
1 secretase
2 prion disease
3 energy landscape
4 beta secretase
5 model alzheimer
6 model alzheimer disease
7 beta sheet
8 protein folding
9 human prion disease
10 mouse model alzheimer
11 yeast prion
12 alzheimer amyloid
13 beta amyloid fibril
14 gamma secretase
15 aptamer
16 beta amyloid
17 alzheimer beta amyloid
18 abeta peptide
19 alzheimer beta
20 amyloid beta peptide
21 amyloid beta
22 alzheimer amyloid beta
23 amyloid peptide
24 alpha synuclein
25 amyloid protofilament
26 app ps1
27 alzheimer abeta peptide
28 peptide alzheimer
29 prion peptide
30 peptide alzheimer disease
31 yeast prion protein
32 human prion
33 synuclein
34 neuroprotective effect
35 huntingtin
36 prion protein
37 amyloid plaque
38 amyloid fibril formation
39 amyloid fibril
40 abeta amyloid
41 tau peptide
42 dimensional structure
43 abeta42
44 amyloid beta fibril
45 humanin
46 human prion protein
47 pathogenesis alzheimer disease
48 amyloidogenic protein
49 nanotube
50 beta peptide alzheimer
51 prion protein amyloid
52 amyloid precursor protein
53 alzheimer disease mouse
54 pi stacking
55 beta amyloid peptide
56 abeta
57 alzheimer abeta
58 peptide amyloid
59 maghemite nanoparticle
60 ubiquitin
61 neurodegeneration
62 amyloid beta protein
63 prp
64 amylin
65 cyclin dependent kinase
66 beta oligomer
67 tau phosphorylation
68 prion protein fragment
69 surfactant protein
70 amyloid imaging
71 beta sheet structure
72 neurodegenerative
73 bioinorganic chemistry
74 lipid raft
75 memantine
76 lung surfactant protein
77 conformationally
78 lewy body
79 amyloid protein
80 peptide folding
81 prion related
82 chaperone
83 neurodegenerative disease
84 sup35p
85 amyloidogenic
86 copper binding protein
87 hiv-1
88 paired helical
89 neuroprotection
90 lewy body alzheimer
91 polymorphism alzheimer
92 glycation
93 beta amyloid protein
94 neurodegenerative disorder
95 abeta amyloid fibril
96 beta amyloid deposit
97 amyloidogenic fragment
98 prion
99 molecular chaperone
100 binding amyloid
101 fibril formation
102 a{beta
103 risk alzheimer disease
104 beta secretase cleavage
105 folding
106 agrin
107 molecular cloning
108 cd study
109 alzheimer disease amyloid
110 mutation amyloid
111 lithostathine
112 paired helical filament
113 treatment alzheimer disease
114 disease beta amyloid
115 app ps1 mice
116 copper amyloid beta
117 alzheimer disease model
118 prion a
119 prion amyloid
120 creutzfeldt jakob disease
121 prion protein a
122 protein prp
123 metal ion
124 sporadic creutzfeldt jakob
125 gene polymorphism
126 body alzheimer disease
127 cdna
128 transgenic mouse model
129 disease dementia
130 mutant huntingtin
131 variant creutzfeldt jakob
132 dichroism
133 full length
134 app
135 transthyretin
136 molecular mechanism alzheimer
137 high throughput
138 copper binding
139 alzheimer a beta
140 alzheimer disease beta
141 fibril alzheimer
142 associated alzheimer disease
143 conformation dynamic
144 precursor protein app
145 soluble amyloid beta
146 oxidative stress
147 precursor protein
148 self assembly
149 polymorphism codon
150 antisense oligonucleotide
151 bind amyloid
152 prion protein prp
153 ion channel
154 intrinsic disorder
155 neuroprotective
156 raft
157 tau
158 alzheimer disease parkinson
159 copper homeostasis
160 amyloid prion
161 amyloid induced toxicity
162 ps1
163 x ray diffraction
164 soluble amyloid
165 cellular prion protein
166 amyloid fibril forming
167 amyloid
168 bcl-2
169 calcineurin
170 helix loop helix
171 role metal ion
172 familial alzheimer disease
173 three dimensional structure
174 lung surfactant
175 apolipoprotein e
176 amyloid formation
177 beta peptide
178 conformational change
179 potentially amyloidogenic
180 amyloid structure
181 fibril
182 protein conformational
183 lewy body dementia
184 sporadic alzheimer disease
185 diffraction
186 imaging agent
187 basic helix loop
188 thiol disulfide
189 conformational
190 alzheimer pathology
191 surfactant
192 bace
193 protein conformation
194 alignment
195 inhibit abeta
196 fold
197 dependent kinase
198 oligonucleotide
199 animal model alzheimer
200 leucine rich
201 landscape
202 therapy alzheimer disease
203 nanoparticle
204 helix
205 cultured neuron
206 reporter
207 bacillus subtilis
208 helical
209 gene encoding
210 beta protein
211 pro inflammatory cytokine
212 linkage
213 d amino acid
214 prp106-126
215 p glycoprotein
216 alzheimer disease diagnosis
217 protein amyloid
218 superoxide dismutase
219 transgenic mouse
220 antioxidant
221 pkc
222 conformation
223 scrapie
224 familial creutzfeldt jakob
225 protein assembly
226 role oxidative stress
227 binding domain
228 leucine rich repeat
229 box
230 dendrimer
231 amber
232 associated neurodegenerative
233 diagnosis neurodegenerative
234 protein aggregation
235 nucleation
236 magnetic field
237 rat cortical
238 mechanism alzheimer
239 transcription factor
240 denaturation
241 mediated neurotoxicity
242 superoxide
243 hiv-1 protein
244 rat hippocampal
245 amyloid form
246 patient alzheimer disease
247 oxide synthase
248 amyloid beta toxicity
249 jakob disease a
250 disulfide
251 fibril forming
252 induced alignment
253 protein fragment
254 amino acid substitution
255 gnrh
256 alzheimer disease
257 endosome
258 pkc alpha
259 hippocampal neuronal
260 transgenic animal model
261 prion protein electron
262 calcineurin induced
263 fddnp
264 serpin
265 stage amyloid
266 nitric oxide synthase
267 mouse model
268 c terminal
269 simulation amyloid
270 surfactant protein c
271 uv cd
272 glycosaminoglycan
273 encephalopathy
274 abca1
275 cyclin
276 design novel
277 codon
278 alzheimer
279 protein peptide
280 pet
281 apolipoprotein
282 antisense
283 frontal lobe
284 chromogranin
285 oligomerization
286 misfolding
287 pc12 cell
288 uv
289 bacillus subtilis natto
290 cu
291 disease parkinson disease
292 amyloid beta oligomer
293 flupirtine
294 protein kinase c
295 identification characterization
296 fibril detection
297 human neuronal
298 role metal
299 mechanism alzheimer disease
300 protein mrna
301 glycosylation
302 protein regulate
303 protein phosphatase
304 n terminal
305 protein misfolding
306 dural
307 naphthalene
308 interaction protein
309 repeat
310 apoptotic
311 intrinsic disorder protein
312 channel
313 kinase c
314 glycolipid
315 point mutation
316 dimeric
317 proapoptotic
318 domain
319 cd
320 tauopathy
321 change pore
322 multimodal imaging
323 pro inflammatory
324 progenitor cell
325 thiol
326 conformational diversity
327 model neurodegenerative
328 peptide aggregation
329 fibril alzheimer disease
330 amyloid fibril alzheimer
331 agent alzheimer
332 stacking
333 region alzheimer
334 creutzfeldt jakob
335 polymerization
336 regulatory region
337 glyoxal
338 dementia a
339 glycolipid binding
340 simulation
341 case control study

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

 

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

alzheimers disease AND amylo... prion disease nmr spectroscopy
1: Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases. 2010
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2: Fundamentals of prion diseases and their involvement in the loss of function of cellular prion protein. 2009
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3: Synthesis of monomeric and dimeric acridine compounds as potential therapeutics in Alzheimer and prion diseases. 2009
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4: Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease. 2007
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5: Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer's and prion diseases. 2006
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6: Delineating common molecular mechanisms in Alzheimer's and prion diseases. 2006
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7: Amyloid associated proteins in Alzheimer's and prion disease. 2005
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8: Prion disease and Alzheimer's disease: pathogenic overlap. 2004
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9: ADAM proteases: protective role in Alzheimer's and prion diseases? 2004
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10: Immunohistochemistry for the prion protein: comparison of different monoclonal antibodies in human prion disease subtypes. 2002
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11: Aging, the brain and human prion disease. 2002
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12: Immunization treatment approaches in Alzheimer's and prion diseases. 2002
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13: Therapeutics in Alzheimer's and prion diseases. 2002
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14: Protein conformational misfolding and amyloid formation: characteristics of a new class of disorders that include Alzheimer's and Prion diseases. 2002
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15: Neuroinflammation in Alzheimer's disease and prion disease. 2002
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16: Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators. 2002
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17: Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases. 2002
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18: The prion diseases. 2000
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19: Alzheimer's and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches. 1999
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20: Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases. 1998
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21: [Conformation and neurotoxicity: relationship between Alzheimer's disease and prion disease] 1998
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22: From prion diseases to Alzheimer's disease. 1997
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23: Frontal lobe dementia is not a variant of prion disease. 1993
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24: Neuropathology of human prion diseases (spongiform encephalopathies). 1993
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25: A kinetic model for amyloid formation in the prion diseases: importance of seeding. 1993
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26: Molecular biology and transgenetics of prion diseases. 1991
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1: Prion disease: Brain MRI studies in prion disease. 2010
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2: Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases. 2010
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3: Magnetic resonance diagnostic markers in clinically sporadic prion disease: a combined brain magnetic resonance imaging and spectroscopy study. 2009
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4: Neuroimaging in human prion disease: Searching in the mist. 2009
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5: Neuroimaging findings in human prion disease. 2007
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6: MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. 2007
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7: Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy. 2006
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8: Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy. 2006
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1 2 
Top Years
Publications
 
2009
 
36
2010
 
33
2006
 
27
2008
 
23
2002
 
23
2007
 
22
1995
 
21
2005
 
20
2003
 
20
2001
 
20
1994
 
18
2004
 
17
2000
 
16
1998
 
12
1993
 
12
1996
 
11
1991
 
10
1992
 
9
1997
 
8
1986
 
5
1 2 
 
1 2 
Top Countries
Publications
 
USA
 
117
United Kingdom
 
44
Germany
 
30
Japan
 
28
Italy
 
20
France
 
20
Australia
 
10
Poland
 
10
Switzerland
 
8
Spain
 
8
Portugal
 
6
Austria
 
6
Belgium
 
5
Chile
 
5
Israel
 
4
Brazil
 
4
Sweden
 
4
Canada
 
3
Netherlands
 
3
South Korea
 
2
1 2 
 
1 2 3 ...8 
Top Cities
Publications
 
London
 
12
New York City
 
10
San Francisco
 
8
Zürich, Switzerland
 
7
Munich
 
7
Milan
 
7
Los Angeles
 
7
Indianapolis
 
7
Melbourne
 
7
?ód?
 
7
Boston
 
7
Cambridge, USA
 
6
Leeds
 
6
Wien
 
6
Fukuoka, Japan
 
6
Cleveland
 
5
Santiago, Chile
 
5
Tokyo
 
5
Chicago
 
5
Baltimore
 
5
1 2 3 ...8 
 
1 2 3 ...10 
Top Journals
Publications
 
J Biol Chem
 
14
P Natl Acad Sci Usa
 
12
Acta Neuropathol
 
11
Prion
 
9
J Neurosci
 
9
Neurology
 
8
Nature
 
7
Science
 
6
Neurosci Lett
 
6
Brain Pathol
 
5
Curr Med Chem
 
5
Neurobiol Aging
 
5
Neurobiol Dis
 
5
Ann Neurol
 
5
Am J Pathol
 
5
Proc Natl Acad Sci U S A
 
4
Neuropathology
 
4
Curr Alzheimer Res
 
4
Trends Biochem Sci
 
4
Embo J
 
4
1 2 3 ...10 
 
1 2 3 ...121 
Top Terms
Publications
 
Alzheimer Disease
 
363
Prions
 
342
Humans
 
330
Proteins
 
309
Amyloid
 
209
Amyloid beta-Protein
 
195
Animals
 
192
Prion Diseases
 
174
Amyloid beta A4 protein
 
134
Peptides
 
120
Neurodegenerative Diseases
 
113
Neurons
 
104
Mice
 
93
Senile Plaques
 
88
Major prion protein
 
87
Brain
 
85
Creutzfeldt-Jakob Syndrome
 
83
Mutation
 
83
fibril
 
82
Patients
 
77
1 2 3 ...121 
 
1 2 3 ...66 
Top Authors
Publications
 
Beyreuther K
 
12
Kitamoto T
 
10
Tateishi J
 
10
Liberski P
 
9
Prusiner S
 
9
Tagliavini F
 
8
Bugiani O
 
7
Masters C
 
7
Ghetti B
 
6
Frangione B
 
6
Hooper N
 
5
Wisniewski T
 
5
Multhaup G
 
5
Cappai R
 
5
Soto C
 
5
Ironside J
 
5
Inestrosa N
 
4
Armstrong R
 
4
Hauw J
 
4
Sigurdsson E
 
4
1 2 3 ...66 
Start A-Literature C-Literature B-list Filter Literature
  A-query: alzheimers disease AND amyloid fibrils...
C-query: nmr spectroscopy
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 10 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 4643 and can be accessed from the start page after you leave this session. There are 1532 terms on the current B-list (342 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.



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