The system is available in two versions: "closed discovery" and "open discovery".
Closed discovery allows the input of two concepts (Example 1: a disorder and a gene. Example 2: a drug and a side effect) and generates potential explanations of the relationship between two entities. It does this by searching published literature to finds intermediate links.
Open discovery allows the input of a single concept, then categories for first-order relatives of that concept, then categories for relatives of those first order concepts. Thus it can link from a disease to related drugs, then to genes related to those drugs and then test if those genes have been mentioned/tested in association with the disease. If the answer is no, then the gene is potentially related yet untested in the literature. Thus the open discovery tool is a nominator of new genes, drugs or neuroscience correlates to be investigated with diseases, disorders, physiological responses or any other phenotype.
Please click on the pictures to access the following tools: (NOTE: If you have not used BITOLA before, please read the tutorial below first)
