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刘德培院士研究论文被引用情况
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博主：
刘院士，我们中国医学科学院院长、北京协和医学院校长。南有湘雅、北有协和的说法，严谨、博精、创新、奉献的协和学风在他身上充分体现。他总是那样的谦虚谨慎，和蔼可亲。我特别爱听他的讲课和学术报告。他给了我们很多具体的科研指导。
http://baike.baidu.com/view/78367.htm
刘德培（1950～），男，1950年5月4日生，安徽阜南人，中国工程院院士、医学分子生物学家，现任中国医学科学院院长、中国协和医科大学校长、中国协和医科大学研究生院院长，中国工程院原副院长。
重大发现
在胎儿型珠蛋白基因重新开启表达与珠蛋白基因表达调控和地中海贫血基因治疗的研究中，
发现马利兰可显著增强成年贫血恒河猴与β地贫患者胎儿型珠蛋白基因的表达；
发现HS2是β基因红系增强子及其关键部位NFE 2/AP I位点；
发现不同长度的红系增强子在反转录病毒载体介导的基因转移中增强β基因的表达；
发现TC1转座子在哺乳动物细胞中发生高频倒位；
证明基因座控制区与近端调节元件共同指导β珠蛋白基因簇的发育调控；
建立了βE与b41/42基因、BAC介导的a/b-珠蛋白基因簇和人载脂蛋白AI/CIII/AIV/AV基因簇三类转基因动物模型；
用杂合寡核苷酸介导实现了β基因定点修复。
http://scholar.google.com/scholar?start=0&q=DP+Liu+++gene++&hl=en&as_sdt=2000
pnas.org [PDF]… , DP Liu, W Liu, JC Chang, YW … - Proceedings of the …, 1989 - National Acad Sciences
... Human fi-globin gene expression in transgenic mice is enhanced by a distant DNase I
hypersensitive site (Southern blot/ribonuclease protection assay/tissue-specific expression)
PETER T. CURTIN*, DEPEI LIU*t, WEN LIu*, JUDY C. CHANG*, AND YUET WAI KAN* ...
Cited by 110 - Related articles - All 9 versions
... Human fi-globin gene expression in transgenic mice is enhanced by a distant DNase I
hypersensitive site (Southern blot/ribonuclease protection assay/tissue-specific expression)
PETER T. CURTIN*, DEPEI LIU*t, WEN LIu*, JUDY C. CHANG*, AND YUET WAI KAN* ...
Cited by 110 - Related articles - All 9 versions
HL Li, DP Liu, CC Liang - Journal of molecular medicine, 2003 - Springer
... De-Pei Liu received his Ph.D. in bio- chemistry and molecular biol- ogy from Peking
Union Medical College. ... His major research interests include gene regulation of globin
gene clus- ters, gene therapy, and cardio- vascular diseases. ...
Cited by 81 - Related articles - BL Direct - All 5 versions
... De-Pei Liu received his Ph.D. in bio- chemistry and molecular biol- ogy from Peking
Union Medical College. ... His major research interests include gene regulation of globin
gene clus- ters, gene therapy, and cardio- vascular diseases. ...
Cited by 81 - Related articles - BL Direct - All 5 versions
CM Liu, DP Liu, WJ Dong, CC Liang - Biochemical and biophysical …, 2004 - Elsevier
RNA interference (RNAi) is the mechanism of sequence-specific, post-transcriptional gene silencing
initiated by short interfering RNAs (siRNAs) homologous to the gene being suppressed.
siRNAs, which mediate sequence-specific mRNA degradation, are duplexes of about ...
Cited by 47 - Related articles - All 5 versions
RNA interference (RNAi) is the mechanism of sequence-specific, post-transcriptional gene silencing
initiated by short interfering RNAs (siRNAs) homologous to the gene being suppressed.
siRNAs, which mediate sequence-specific mRNA degradation, are duplexes of about ...
Cited by 47 - Related articles - All 5 versions
nih.gov [HTML]GH Wei, DP Liu, CC Liang - Biochemical Journal, 2004 - ncbi.nlm.nih.gov
One of the foremost challenges in the post-genomic era will be to chart the gene regulatory networks
of cells, including aspects such as genome annotation, identification of cis-regulatory elements
and transcription factors, information on protein–DNA and protein–protein interactions, ...
Cited by 41 - Related articles - BL Direct - All 8 versions
One of the foremost challenges in the post-genomic era will be to chart the gene regulatory networks
of cells, including aspects such as genome annotation, identification of cis-regulatory elements
and transcription factors, information on protein–DNA and protein–protein interactions, ...
Cited by 41 - Related articles - BL Direct - All 8 versions
nih.gov [HTML]… Watt, KSE Cheah, JD Huang, DP Liu, … - Proceedings of the …, 2005 - National Acad Sciences
Targeted gene modification mediated by single-stranded oligonucleotides (SSOs) holds great
potential for widespread use in a number of biological and biomedical fields, including functional
genomics and gene therapy. By using this approach, specific genetic changes have been ...
Cited by 41 - Related articles - All 14 versions
Targeted gene modification mediated by single-stranded oligonucleotides (SSOs) holds great
potential for widespread use in a number of biological and biomedical fields, including functional
genomics and gene therapy. By using this approach, specific genetic changes have been ...
Cited by 41 - Related articles - All 14 versions
uga.edu [PDF]XS Ke, CM Liu, DP Liu, CC Liang - Current opinion in chemical biology, 2003 - Elsevier
Four decades ago, the Central Dogma was formulated and simplified as 'DNA makes RNA, and
RNA makes protein'. As a result, RNAs have been looked as simple molecules that merely convert
genetic information into protein. However, it has been estimated that although most of the ...
Cited by 38 - Related articles - All 8 versions
Four decades ago, the Central Dogma was formulated and simplified as 'DNA makes RNA, and
RNA makes protein'. As a result, RNAs have been looked as simple molecules that merely convert
genetic information into protein. However, it has been estimated that although most of the ...
Cited by 38 - Related articles - All 8 versions
ZH Li, DP Liu, WX Yin, ZC Guo, CC Liang - Blood Cells, Molecules, and …, 2001 - Elsevier
An RNA/DNA chimeric oligonucleotide was found to be effective in the targeted correction of
point mutations in Escherichia coli, plant, and mammalian genomes. This strategy, named
chimeraplasty, has the potential for gene therapy of many genetic diseases caused by ...
An RNA/DNA chimeric oligonucleotide was found to be effective in the targeted correction of
point mutations in Escherichia coli, plant, and mammalian genomes. This strategy, named
chimeraplasty, has the potential for gene therapy of many genetic diseases caused by ...
HC Zhan, DP Liu, CC Liang - Human genetics, 2001 - Springer
Abstract An insulator or boundary element is a novel class of regulatory sequence and has properties
consistent with a role in limiting enhancer activity; it helps to define the boundary between differentially
regulated loci. Origi- nally, an insulator was defined operationally by its ability to protect ...
Cited by 23 - Related articles - BL Direct - All 4 versions
Abstract An insulator or boundary element is a novel class of regulatory sequence and has properties
consistent with a role in limiting enhancer activity; it helps to define the boundary between differentially
regulated loci. Origi- nally, an insulator was defined operationally by its ability to protect ...
Cited by 23 - Related articles - BL Direct - All 4 versions
AB Wang, DP Liu, CC Liang - Experimental cell research, 2003 - Elsevier
Apolipoprotein B is a large, amphipathic protein that plays a central role in lipoprotein
metabolism. Because its overproduction and deficiency leads to metabolic and pathologic
disorders, much effort has been paid to investigate the mechanisms of how its ...
Cited by 23 - Related articles - All 5 versions
Apolipoprotein B is a large, amphipathic protein that plays a central role in lipoprotein
metabolism. Because its overproduction and deficiency leads to metabolic and pathologic
disorders, much effort has been paid to investigate the mechanisms of how its ...
Cited by 23 - Related articles - All 5 versions
Y Huang, DP Liu, L Wu, TC Li, M Wu, DX Feng, … - Blood Cells, Molecules, …, 2000 - Elsevier
... 1989) p. 9–31 . 26. QH Liu, DP Liu, YZ Ding, QZ Wei, PC Jia, SS Chen and CC Liang,
Expression of human β-globin gene with erythroid enhancer in transgenic mouse.
Sci. China B 37 (1994), pp. 20–25. 27. M. Bulger, JH van ...
Cited by 30 - Related articles - BL Direct - All 4 versions
... 1989) p. 9–31 . 26. QH Liu, DP Liu, YZ Ding, QZ Wei, PC Jia, SS Chen and CC Liang,
Expression of human β-globin gene with erythroid enhancer in transgenic mouse.
Sci. China B 37 (1994), pp. 20–25. 27. M. Bulger, JH van ...
Cited by 30 - Related articles - BL Direct - All 4 versions
N Zhao, DP Liu, CC Liang - Molecular biotechnology, 2001 - Springer
Adeno-associated virus (AAV) is a promising viral vector in treating many kinds of hereditary
diseases. The broad host range, low level of immune response, and longevity of gene expression
observed with this vector have enabled the initiation of a number of clinical trials using ...
Cited by 17 - Related articles - BL Direct - All 6 versions
Adeno-associated virus (AAV) is a promising viral vector in treating many kinds of hereditary
diseases. The broad host range, low level of immune response, and longevity of gene expression
observed with this vector have enabled the initiation of a number of clinical trials using ...
Cited by 17 - Related articles - BL Direct - All 6 versions
XS Wu, DP Liu, CC Liang - Journal of Biomedical Science, 2001 - Springer
Abstract A strategy called targeted gene repair was developed to facilitate the process of gene
therapy using a chimeric RNA-DNA oligonucteotide. Experiments demonstrated the feasibility
of using the chimeric oligonucleotide to introduce point conversion in genes in vitro and in ...
Cited by 14 - Related articles - BL Direct - All 5 versions
Abstract A strategy called targeted gene repair was developed to facilitate the process of gene
therapy using a chimeric RNA-DNA oligonucteotide. Experiments demonstrated the feasibility
of using the chimeric oligonucleotide to introduce point conversion in genes in vitro and in ...
Cited by 14 - Related articles - BL Direct - All 5 versions
nih.gov [HTML]MSY Huen, X Li, LY Lu, RM Watt, DP Liu, … - Nucleic acids …, 2006 - Oxford Univ Press
Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential
for use in functional genomic studies and gene therapy. Genetic changes have been created
using this approach in a number of prokaryotic and eukaryotic systems, including mouse ...
Cited by 16 - Related articles - BL Direct - All 13 versions
Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential
for use in functional genomic studies and gene therapy. Genetic changes have been created
using this approach in a number of prokaryotic and eukaryotic systems, including mouse ...
Cited by 16 - Related articles - BL Direct - All 13 versions
pnas.org [HTML]DX Feng, DP Liu, Y Huang, L Wu, TC … - Proceedings of the …, 2001 - National Acad Sciences
... J,; Kawasaki K,; Minoshima S,; Shimizu N. (1997) Gene 191:69–79, pmid:9210591. ↵: Antoch
MP,; Song EJ,; Chang AM,; Vitaterna MH,; Zhao Y,; Wilsbacher LD,; Sangoram AM,; King DP,;
Pinto LH,; Takahashi JS. (1997) Cell 89:655–667, pmid:9160756. ↵: Huang Y,; Liu DP,; Wu ...
Cited by 31 - Related articles - BL Direct - All 8 versions
... J,; Kawasaki K,; Minoshima S,; Shimizu N. (1997) Gene 191:69–79, pmid:9210591. ↵: Antoch
MP,; Song EJ,; Chang AM,; Vitaterna MH,; Zhao Y,; Wilsbacher LD,; Sangoram AM,; King DP,;
Pinto LH,; Takahashi JS. (1997) Cell 89:655–667, pmid:9160756. ↵: Huang Y,; Liu DP,; Wu ...
Cited by 31 - Related articles - BL Direct - All 8 versions
HC Wong, MC Chen, SH Liu, DP Liu - International journal of food …, 1999 - Elsevier
... H. -C. Wong Corresponding Author Contact Information , E-mail The Corresponding Author ,
a , M. -C. Chen b , S. -H. Liu a and D. -P. Liu c. ... (1997a) the clinical originated urease positive
strains show stronger correlation with the trh gene than with the tdh gene. ...
Cited by 48 - Related articles - All 8 versions
... H. -C. Wong Corresponding Author Contact Information , E-mail The Corresponding Author ,
a , M. -C. Chen b , S. -H. Liu a and D. -P. Liu c. ... (1997a) the clinical originated urease positive
strains show stronger correlation with the trh gene than with the tdh gene. ...
Cited by 48 - Related articles - All 8 versions
CM Liu, DP Liu, CC Liang - Journal of molecular medicine, 2002 - Springer
Point or highly localized mutations cause many mono- genic diseases which can be corrected
by gene replace- ment or gene repair. In gene replacement therapy a thera- peutic gene usually
mediated by virus is transferred to the cell or affected organ. Unlike gene replacement, ...
Cited by 11 - Related articles - BL Direct - All 6 versions
Point or highly localized mutations cause many mono- genic diseases which can be corrected
by gene replace- ment or gene repair. In gene replacement therapy a thera- peutic gene usually
mediated by virus is transferred to the cell or affected organ. Unlike gene replacement, ...
Cited by 11 - Related articles - BL Direct - All 6 versions
nih.gov [HTML]… Liu, TK Wang, CL Lee, CS Chiou, DP Liu, … - Applied and …, 2000 - Am Soc Microbiol
... HIN-CHUNG WONG,1* SHU-HUI LIU,1 TIEN-KUEI WANG,2 CHIH-LUNG LEE,2 CHIEN-SHUN
CHIOU,2 DING-PING LIU,3 MITSUAKI NISHIBUCHI,4 AND BOK-KWON LEE5 ... All recently isolated
O3:K6 strains carried the thermostable direct hemolysin (tdh) gene. ...
Cited by 81 - Related articles - BL Direct - All 7 versions
... HIN-CHUNG WONG,1* SHU-HUI LIU,1 TIEN-KUEI WANG,2 CHIH-LUNG LEE,2 CHIEN-SHUN
CHIOU,2 DING-PING LIU,3 MITSUAKI NISHIBUCHI,4 AND BOK-KWON LEE5 ... All recently isolated
O3:K6 strains carried the thermostable direct hemolysin (tdh) gene. ...
Cited by 81 - Related articles - BL Direct - All 7 versions
XH Fu, DP Liu, CC Liang - Experimental cell research, 2002 - Elsevier
... Curr. Opin. Gene Dev. 10 (2000), pp. 199–203. Article | PDF (117 K) | View Record in Scopus |
Cited By in Scopus (57). 16. XG Li, DP Liu and CC Liang, Beyond the locus control region: New
light on β-globin locus regulation. Int. J. Biol. Cell. Biol. 33 (2001), pp. 914–923. ...
Cited by 23 - Related articles - BL Direct - All 6 versions
... Curr. Opin. Gene Dev. 10 (2000), pp. 199–203. Article | PDF (117 K) | View Record in Scopus |
Cited By in Scopus (57). 16. XG Li, DP Liu and CC Liang, Beyond the locus control region: New
light on β-globin locus regulation. Int. J. Biol. Cell. Biol. 33 (2001), pp. 914–923. ...
Cited by 23 - Related articles - BL Direct - All 6 versions
ZY Li, DP Liu, CC Liang - Leukemia, 2004 - nature.com
... Correspondence: Dr DP Liu, National Laboratory of Medical Molecular Biology, Institute of Basic
Medical Sciences, Chinese Academy of Medical Sciences ... Rearrangements of the MLL gene
(ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in ...
Cited by 44 - Related articles - All 5 versions
... Correspondence: Dr DP Liu, National Laboratory of Medical Molecular Biology, Institute of Basic
Medical Sciences, Chinese Academy of Medical Sciences ... Rearrangements of the MLL gene
(ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in ...
Cited by 44 - Related articles - All 5 versions
MSY Huen, LY Lu, DP Liu, JD Huang - Biochemical and biophysical …, 2007 - Elsevier
The λ-Red-mediated recombination has been exploited as an efficient means for DNA
manipulation. We previously reported that replication plays a pivotal role during this process.
Replication direction dictates strand bias, such that single stranded oligonucleotide (SSO) ...
Cited by 10 - Related articles - All 7 versions
The λ-Red-mediated recombination has been exploited as an efficient means for DNA
manipulation. We previously reported that replication plays a pivotal role during this process.
Replication direction dictates strand bias, such that single stranded oligonucleotide (SSO) ...
Cited by 10 - Related articles - All 7 versions
HB Zhang, DP Liu, CC Liang - International journal of hematology, 2002 - ncbi.nlm.nih.gov
The alpha-globin gene cluster is located at the very tip of the short arm of chromosome 16. It
produces the alpha-like globins, which is combined with the beta-like globins to form
hemoglobin, and its mutants cause alpha-thalassemia, which
The alpha-globin gene cluster is located at the very tip of the short arm of chromosome 16. It
produces the alpha-like globins, which is combined with the beta-like globins to form
hemoglobin, and its mutants cause alpha-thalassemia, which
L Liang, DP Liu, CC Liang - European Journal of …, 2002 - interscience.wiley.com
... Science 273, 1386–1389. 12. Wu, XS, Liu, DP & Liang, CC (2001) Prospects of chimeric
RNA-DNA oligonucleotides in gene therapy. J. Biomed. Sci. 8, 439–445. 13. Rice, MC, Czymmek,
K. & Kmiec, EB (2001) The potential of nucleic acid repair in functional genomics. ...
Cited by 15 - Related articles - BL Direct - All 7 versions
... Science 273, 1386–1389. 12. Wu, XS, Liu, DP & Liang, CC (2001) Prospects of chimeric
RNA-DNA oligonucleotides in gene therapy. J. Biomed. Sci. 8, 439–445. 13. Rice, MC, Czymmek,
K. & Kmiec, EB (2001) The potential of nucleic acid repair in functional genomics. ...
Cited by 15 - Related articles - BL Direct - All 7 versions
H Gong, CM Liu, DP Liu, CC … - Medicinal research …, 2005 - interscience.wiley.com
... Small RNAs of 22 nucleotides (nt) in length, which are ubiquitous, versatile repressors of gene
expression in plants, animals, and many ... Correspondence to: De-Pei Liu, National Laboratory
of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of ...
... Small RNAs of 22 nucleotides (nt) in length, which are ubiquitous, versatile repressors of gene
expression in plants, animals, and many ... Correspondence to: De-Pei Liu, National Laboratory
of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of ...
YC Hsieh, TZ Wu, DP Liu, PL Shao, LY Chang, … - Journal of the Formosan …, 2006 - Elsevier
... Antigen shift is derived from reassortment of gene segments between viruses, and may result
in an antigenically novel virus that is capable of ... first, followed by REVIEW ARTICLE Influenza
Pandemics: Past, Present and Future Yu-Chia Hsieh, Tsung-Zu Wu, 1 Ding-Ping Liu, 2 Pei ...
Cited by 41 - Related articles - BL Direct - All 5 versions
... Antigen shift is derived from reassortment of gene segments between viruses, and may result
in an antigenically novel virus that is capable of ... first, followed by REVIEW ARTICLE Influenza
Pandemics: Past, Present and Future Yu-Chia Hsieh, Tsung-Zu Wu, 1 Ding-Ping Liu, 2 Pei ...
Cited by 41 - Related articles - BL Direct - All 5 versions
nih.gov [HTML]… Xin, W Song, LJ Di, G Liu, XS Wu, DP Liu, … - … and cellular biology, 2006 - Am Soc Microbiol
... at 1 and 2 in liver cells, but there is no NF-E2p45 occupancy at these sites in brain cells (GL Zhou
and DP Liu, unpublished data). ... In mouse definitive erythroid cells, the fetal and adult 1 and 2
gene promoters are highly enriched with histone acetylation and H3-K4 dimethylation. ...
Cited by 40 - Related articles - BL Direct - All 8 versions
... at 1 and 2 in liver cells, but there is no NF-E2p45 occupancy at these sites in brain cells (GL Zhou
and DP Liu, unpublished data). ... In mouse definitive erythroid cells, the fetal and adult 1 and 2
gene promoters are highly enriched with histone acetylation and H3-K4 dimethylation. ...
Cited by 40 - Related articles - BL Direct - All 8 versions
Z Wang, ZJ Zhou, DP Liu, JD Huang - Biochemical and biophysical …, 2006 - Elsevier
Single-stranded DNA oligonucleotide (SSO)-mediated gene repair has great potentials for gene
therapy and functional genomic studies. However, its underlying mechanism remains
unclear. Previous studies from other groups have suggested that DNA damage response ...
Cited by 8 - Related articles - All 7 versions
Single-stranded DNA oligonucleotide (SSO)-mediated gene repair has great potentials for gene
therapy and functional genomic studies. However, its underlying mechanism remains
unclear. Previous studies from other groups have suggested that DNA damage response ...
Cited by 8 - Related articles - All 7 versions
WJ Dong, XB Wu, DP Liu, J Li, G Liu, ZX Zu, N … - Journal of biomedical …, 2002 - Springer
Abstract Adeno-associated virus (AAV)-2 was developed as a use- ful vector for human gene
therapy. In this report, we ana- lyzed the integration and expression of AAV-mediated ex vivo
transferred human 13-globin gene in bone marrow (BM) reconstituted mice. Recombinant ...
Abstract Adeno-associated virus (AAV)-2 was developed as a use- ful vector for human gene
therapy. In this report, we ana- lyzed the integration and expression of AAV-mediated ex vivo
transferred human 13-globin gene in bone marrow (BM) reconstituted mice. Recombinant ...
XB Tang, DP Liu, CC Liang - Cellular and molecular life Sciences, 2001 - Springer
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese
Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005 (PR
China), Fax + 86 10 65240529, e-mail address: liudp@public.east.cn.net
Cited by 8 - Related articles - BL Direct - All 5 versions
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese
Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005 (PR
China), Fax + 86 10 65240529, e-mail address: liudp@public.east.cn.net
Cited by 8 - Related articles - BL Direct - All 5 versions
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