研究进展：

http://www.bioon.com/biology/cell/449203.shtml

Cell：糖尿病或由骨骼变化诱发

知识发现平台：

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

Start A-Literature C-Literature B-list Filter Literature

A-query: osteoblasts C-query: glucose homeostasis The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 16 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 29092 and can be accessed from the start page after you leave this session. There are 1128 terms on the current B-list (420 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 29092 started Sat Jul 31 01:58:20 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
29092 Search ARROWSMITH A
A_query_raw: osteoblasts Sat Jul 31 01:58:42 2010

A query = osteoblasts started Sat Jul 31 01:58:42 2010
A query resulted in 22708 titles
29092 Search ARROWSMITH C
C_query_raw: glucose homeostasis Sat Jul 31 01:59:00 2010

C: glucose homeostasis 16305

A: pubmed_query_A 22708

AC: ( osteoblasts ) AND ( glucose homeostasis ) 16

C query = glucose homeostasis started Sat Jul 31 01:59:01 2010
C query resulted in 16305 titles
A AND C query resulted in 16 titles
13909 B-terms ready on Sat Jul 31 02:02:19 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1128 B-terms left after filter executed Sat Jul 31 02:14:40 2010

B-list on Sat Jul 31 02:17:38 2010
1 adiponectin
2 cox-2
3 jnk
4 wnt
5 c ebp
6 follistatin
7 ccaat enhancer binding
8 akt
9 vegf
10 leptin receptor
11 angiopoietin
12 toll receptor
13 single nucleotide polymorphism
14 stat3
15 mtor
16 c jun n
17 beta catenin
18 nfat
19 ppargamma
20 transporter gene
21 calcium sensing receptor
22 signal regulated kinase
23 ppar gamma
24 insulin receptor substrate
25 eralpha
26 phosphatidylinositol 3-kinase
27 pi3k
28 rho kinase
29 ghrelin
30 hif-1
31 map kinase
32 erbeta
33 estrogen receptor alpha
34 homeodomain protein
35 leptin
36 proximal promoter
37 igfbp-3
38 apelin
39 pten
40 uncoupling protein
41 erk1
42 c jun
43 amylin
44 p38 mapk
45 smad4
46 promoter activity
47 microrna
48 creb
49 statin
50 gene promoter
51 smad
52 ampk
53 homeobox
54 adiponectin receptor
55 islet amyloid polypeptide
56 glycogen synthase
57 sirt1
58 quantitative trait locus
59 cannabinoid receptor
60 melastatin
61 ppar
62 betacellulin
63 er alpha
64 melanocortin receptor
65 vitamin d receptor
66 lamin a c
67 ppar gamma2
68 mmp-2
69 p70 s6 kinase
70 aromatase
71 nrf2
72 klotho
73 genome wide
74 gastric inhibitory polypeptide
75 c ebpalpha
76 cre
77 casein kinase
78 kruppel
79 fgfr3
80 smad5
81 hif-1alpha
82 c fos
83 p38
84 visfatin
85 adenovirus mediated gene
86 s6
87 chemokine
88 nf kappab
89 caspase-3
90 adiponectin gene
91 glucose transporter
92 connexin
93 stat1
94 fgf
95 homeobox gene
96 e2f1
97 growth hormone receptor
98 calreticulin
99 gp130
100 activating transcription factor
101 protein tyrosine phosphatase
102 tgfbeta
103 fdg
104 histone deacetylase
105 il-6
106 matrix metalloproteinase
107 p2y
108 wnt10b
109 stanniocalcin
110 pkb
111 pacap
112 cadherin
113 bone mineral density
114 il-1
115 adrenomedullin
116 ap-1
117 fat mass
118 irs-1
119 hyperparathyroidism
120 pref-1
121 calbindin
122 chromatin remodeling
123 cb1
124 tyrosine phosphatase
125 mmp-9
126 swi snf
127 pkc
128 sp1
129 gene related peptide
130 transcription factor
131 pth
132 creb binding protein
133 bfgf
134 calcitonin gene related
135 insulin receptor
136 adiposity
137 quantitative trait loci
138 calcitonin gene
139 zinc finger protein
140 igf i
141 ephrin
142 src
143 response element
144 erk
145 c ebp alpha
146 glucocorticoid receptor
147 p70
148 cbl
149 pgc-1alpha
150 glycogen synthase kinase
151 tgf beta
152 tnfalpha
153 enhancer
154 myd88
155 igf
156 crem
157 socs-3
158 interleukin
159 synaptotagmin vii
160 hepatocyte growth factor
161 metabolic syndrome
162 camp response element
163 akt pkb
164 expression gene
165 l ca2
166 transgene
167 early gene
168 protein kinase c
169 glut1
170 h atpase
171 pc-1
172 cd38
173 jun
174 add1
175 receptor gene expression
176 kruppel factor
177 estrogen receptor
178 protein-1 gene
179 promoter human
180 dipeptidyl peptidase
181 dlk1
182 receptor kinase
183 fibroblast growth factor
184 gene transfer skeletal
185 cytokine gene
186 foxo1
187 oxide synthase gene
188 p300
189 fgf receptor
190 stem cell proliferation
191 decorin
192 hif
193 tnf alpha
194 ob
195 caspase
196 phospholipase d
197 candidate gene
198 igf-1
199 e box
200 ca atpase
201 neuropeptide y
202 erk2
203 peroxisome
204 galanin
205 immediate early gene
206 pai-1
207 pyk2
208 calcium channel
209 isl-1
210 capd
211 selenoprotein
212 hedgehog
213 angiotensin receptor
214 jnk1
215 foxo
216 androgen receptor
217 annexin
218 matrix gla protein
219 proto oncogene
220 apoe
221 gene insulin
222 npy
223 bcl-2
224 fgfr
225 il-8
226 il6
227 brca1 gene
228 glutaredoxin
229 receptor gene
230 cdna
231 jnk2
232 bb
233 y2
234 hyperinsulinemia
235 vegf a
236 promoter region
237 endothelin
238 alternate promoter
239 d3 receptor
240 neuropeptide w
241 tyrosine kinase
242 osteonectin
243 pge2
244 fkhr
245 bmp
246 cxcl10
247 gene associated
248 neuropeptide
249 toll
250 j2
251 il-18
252 cystatin c
253 hormone receptor gene
254 enpp1
255 bim
256 autophagy
257 receptor promoter
258 tnf
259 chaperone
260 apolipoprotein e
261 phosphate transporter
262 epidermal growth factor
263 ubiquitin
264 fos
265 opioid receptor
266 related gene
267 cytokine
268 egfr
269 cd14
270 gene related
271 bdnf
272 transgene expression
273 irs1
274 cftr
275 clock gene
276 trkb
277 bcl x l
278 c myc
279 dystrophin
280 exon
281 e selectin
282 il-1beta
283 androgen receptor gene
284 hsp27
285 amp response element
286 ncx3
287 tralpha
288 tfe3
289 gene family
290 lrp5
291 islet
292 jak
293 alpha gene
294 chop
295 insulin growth factor
296 caveolin
297 nf
298 ciliary neurotrophic factor
299 repressor
300 pka

Start A-Literature C-Literature B-list Filter Literature

AB literature   B-term   BC literature   osteoblasts jnk glucose homeostasis 1: Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways. 2010 Add to clipboard 2: Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line. 2009 Add to clipboard 3: JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation. 2009 Add to clipboard 4: [JNK signaling in osteoblast differentiation] 2009 Add to clipboard 5: Ultrasound stimulates MMP-13 expression through p38 and JNK pathway in osteoblasts. 2008 Add to clipboard 6: Quercetin accelerates TNF-alpha-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways. 2008 Add to clipboard 7: 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis via JNK-mediated mitochondrial pathway in osteoblastic cells. 2008 Add to clipboard 8: (-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK. 2008 Add to clipboard 9: (--)-epigallocatechin gallate enhances prostaglandin F2alpha-induced VEGF synthesis via upregulating SAPK/JNK activation in osteoblasts. 2007 Add to clipboard 10: Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. 2007 Add to clipboard 11: The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. 2007 Add to clipboard 12: TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling. 2007 Add to clipboard 13: TGF-beta suppresses POEM expression through ERK1/2 and JNK in osteoblasts. 2007 Add to clipboard 14: PPAR-gamma ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts. 2005 Add to clipboard 15: Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. 2005 Add to clipboard 16: SAPK/JNK plays a role in transforming growth factor-beta-induced VEGF synthesis in osteoblasts. 2005 Add to clipboard 17: Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. 2005 Add to clipboard 18: Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation. 2004 Add to clipboard 19: Involvement of stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in prostaglandin F2alpha-induced heat shock protein 27 in osteoblasts. 2004 Add to clipboard 20: Involvement of SAPK/JNK in prostaglandin E(1)-induced VEGF synthesis in osteoblast-like cells. 2004 Add to clipboard 21: Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. 2003 Add to clipboard 22: Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts. 2003 Add to clipboard 23: JNK/SAPK is required in nitric oxide-induced apoptosis in osteoblasts. 2003 Add to clipboard 24: Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. 2002 Add to clipboard 25: Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts. 2002 Add to clipboard   1: Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. 2005 Add to clipboard 2: A central role for JNK in obesity and insulin resistance. 2002 Add to clipboard

 

 

 

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