研究动态

http://www.bioon.com/biology/biomed/448527.shtml

Cancer Res.：华人饮食习惯易致前列腺癌

知识发现平台

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature

A-query: Calcium Intake C-query: Prostate Cancer The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 105 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 23020 and can be accessed from the start page after you leave this session. There are 723 terms on the current B-list (178 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.   Rank   Prob   B-term 1    0.94  adiponectin 2    0.94  promoter polymorphism 3    0.94  codon polymorphism 4    0.93  calcium sensing receptor 5    0.93  pthrp 6    0.93  rankl 7    0.93  igfbp-3 8    0.93  ghrelin 9    0.92  akt 10   0.92  vegf 11   0.92  leptin 12   0.92  mthfr 13   0.92  single nucleotide polymorphism 14   0.92  fat mass 15   0.92  statin 16   0.91  start codon polymorphism 17   0.91  caspase 18   0.91  receptor gene cag 19   0.91  ictp 20   0.91  cannabinoid receptor 21   0.91  mros 22   0.91  phosphatidylinositol 3-kinase 23   0.90  metabolic syndrome 24   0.90  vitamin d receptor 25   0.90  leptin receptor 26   0.90  sp1 27   0.90  body mass index 28   0.89  androgen receptor gene 29   0.89  vdr gene 30   0.88  gastrin releasing peptide 31   0.88  lactase 32   0.88  bone mineral density 33   0.88  hyperparathyroidism 34   0.87  gene promoter 35   0.87  ampk 36   0.87  d pathway gene 37   0.87  codon polymorphism foki 38   0.86  tlr4 39   0.86  igf i 40   0.86  gonadotropin releasing hormone 41   0.86  e cadherin 42   0.85  igf 43   0.85  cyp3a4 44   0.85  microsatellite 45   0.85  bmd 46   0.85  gene cag repeat 47   0.84  microsatellite polymorphism 48   0.84  map kinase 49   0.84  pth 50   0.84  igfbp-2 51   0.84  p38 52   0.83  estrogen receptor 53   0.83  eralpha 54   0.83  aromatase 55   0.83  k ras 56   0.83  fibroblast growth factor 57   0.82  endothelin 58   0.82  gene promoter polymorphism 59   0.82  creb 60   0.82  leptin receptor gene 61   0.82  calcium channel 62   0.82  methylenetetrahydrofolate reductase 63   0.82  estrogen receptor gene 64   0.82  bone morphogenetic protein 65   0.81  nfat 66   0.81  igf-1 67   0.81  cd38 68   0.80  body mass 69   0.80  bone mineral content 70   0.80  hepatocyte growth factor 71   0.80  cag 72   0.80  cadherin 73   0.80  angiotensin receptor 74   0.80  osteocalcin gene 75   0.80  vdr 76   0.80  androgen receptor 77   0.78  receptor gene 78   0.78  cyclophilin 79   0.78  sirt1 80   0.78  adiposity 81   0.78  transcription factor 82   0.77  calcitonin receptor 83   0.77  han 84   0.77  tgfb1 gene 85   0.76  gene associated 86   0.76  gnrh 87   0.76  gene environment 88   0.76  responsive gene 89   0.76  igfbp-1 90   0.76  bran 91   0.76  egfr 92   0.75  erk 93   0.75  pacap 94   0.75  epidermal growth factor 95   0.74  colorectal adenoma carcinoma 96   0.74  enhancer 97   0.74  gene microsatellite 98   0.73  sun 99   0.73  tgf beta1 100  0.73  epic 101  0.73  chaperone 102  0.72  sgk1 103  0.72  at1 104  0.71  insulin growth factor 105  0.71  melastatin 106  0.71  trpv1 107  0.71  megalin 108  0.71  aquaporin 109  0.71  pet 110  0.71  hfe 111  0.70  isoform 112  0.70  hla a 113  0.70  gene association 114  0.69  e beta carotene 115  0.69  metallothionein 116  0.69  parathyroid hormone 117  0.69  kv1 118  0.69  protein kinase 119  0.68  amino acid transporter 120  0.68  glycogen synthase 121  0.68  leptin gene 122  0.68  opg 123  0.68  promoter 124  0.67  nude 125  0.66  c vitamin e 126  0.66  bdnf 127  0.66  cb1 128  0.66  tnfalpha 129  0.66  p selectin 130  0.65  ki ras 131  0.65  ck 132  0.64  lrp5 133  0.64  gene variant 134  0.63  shr 135  0.62  race 136  0.62  l ca2 137  0.61  shp2 138  0.61  apc 139  0.59  tgfb1 140  0.59  obese 141  0.59  calcitonin gene related 142  0.59  gene related peptide 143  0.59  bk 144  0.58  genome screen 145  0.58  calpain 146  0.58  inflammatory bowel disease 147  0.57  calcium binding protein 148  0.57  tea 149  0.57  calmodulin 150  0.56  calcitonin gene 151  0.56  d3 152  0.56  interleukin-6 gene 153  0.56  channel gene 154  0.56  factor beta-1 gene 155  0.56  ubiquitin 156  0.55  dash 157  0.55  sodium pump 158  0.54  polymorphism gene 159  0.54  aromatase gene 160  0.54  related gene 161  0.54  5'-untranslated region 162  0.53  cdx-2 163  0.53  tag 164  0.53  codon 165  0.53  stc-1 166  0.52  orofacial cleft 167  0.51  hyperinsulinemia 168  0.51  cyp1a2 169  0.51  vitamin e 170  0.50  milk 171  0.50  cancer united 172  0.50  pkd1 173  0.50  tyrosine phosphatase 174  0.49  obesity 175  0.49  protein kinase c 176  0.48  egfr expression 177  0.48  neuropeptide y 178  0.47  promoter genotype 179  0.47  platelet activation 180  0.47  c fos 181  0.46  eat 182  0.46  body weight 183  0.46  growth hormone receptor 184  0.45  tgf alpha 185  0.45  aldehyde dehydrogenase 186  0.45  apolipoprotein e 187  0.44  il-1beta 188  0.44  rct 189  0.44  comt 190  0.44  trail 191  0.43  calcitonin 192  0.43  lean 193  0.42  collagen i alpha 194  0.42  gene colorectal 195  0.41  fat 196  0.41  pkc 197  0.41  rank 198  0.40  gastrin 199  0.40  hip 200  0.40  hypoparathyroidism 201  0.40  femur 202  0.39  gene human 203  0.39  meta 204  0.38  somatostatin 205  0.38  juice 206  0.38  pufa 207  0.37  renin 208  0.36  neuropeptide 209  0.36  potassium channel 210  0.36  hemochromatosis 211  0.36  opioid receptor 212  0.36  n ras 213  0.35  d3 receptor 214  0.35  bb 215  0.34  genomic 216  0.33  icam-1 217  0.33  oh 218  0.33  interferon gamma 219  0.33  kinase 220  0.33  axis 221  0.33  breast cancer 222  0.33  erythropoietin 223  0.32  kallikrein 224  0.32  hay 225  0.32  met 226  0.31  resistin 227  0.31  dht 228  0.30  cd8 229  0.30  npy 230  0.30  at2 231  0.30  gene related 232  0.30  catechol o-methyltransferase 233  0.29  max 234  0.29  wilm tumor 235  0.29  retinol binding protein 236  0.28  gene not 237  0.28  uk 238  0.28  allele 239  0.27  ligand 240  0.27  nut 241  0.27  cytokine 242  0.27  ctx 243  0.27  arab 244  0.26  sms 245  0.24  plasminogen 246  0.24  hydrolase gene 247  0.23  ra 248  0.23  reductase 249  0.22  alpha isoform 250  0.22  tnf alpha 251  0.22  hiv 252  0.21  image 253  0.21  gh 254  0.21  senescence 255  0.21  weight 256  0.21  twin 257  0.21  chi 258  0.20  inducible 259  0.20  ornithine decarboxylase 260  0.20  genome 261  0.20  calcium atpase 262  0.20  g protein 263  0.20  beta1 264  0.20  neurotensin 265  0.20  hypercholesterolemia 266  0.19  diabetes mellitus 267  0.19  cytochrome p450 268  0.19  benign 269  0.18  transporter 270  0.18  anorexia 271  0.18  conductance 272  0.18  p450 273  0.18  myosin 274  0.17  glioma 275  0.17  nih 276  0.17  b16 277  0.16  gene 278  0.16  lean body mass 279  0.16  cytosolic 280  0.16  receptor allele 281  0.15  jew 282  0.15  cocoa 283  0.15  tnf 284  0.15  tumor necrosis factor 285  0.15  inositol 286  0.15  asia 287  0.15  triglyceride 288  0.14  atpase 289  0.14  hmg coa reductase 290  0.14  coa 291  0.14  hot 292  0.14  map 293  0.14  serum albumin 294  0.14  odc 295  0.14  variant 296  0.14  sri 297  0.14  tpa 298  0.13  allele not 299  0.13  mass 300  0.13  men 301  0.13  core 302  0.13  phosphate 303  0.12  renal failure 304  0.12  lt 305  0.12  corn 306  0.12  proteinase 307  0.11  pilot 308  0.11  s100 309  0.11  death 310  0.11  cycle 311  0.11  total 312  0.11  atherosclerosis 313  0.11  hla 314  0.10  al 315  0.10  diabetes 316  0.10  hormone metabolism 317  0.10  alzheimer disease 318  0.10  white 319  0.10  male 320  0.10  line 321  0.10  cl 322  0.10  anxiety 323  0.10  ar 324  0.10  phosphatase 325  0.09  d2 326  0.09  si 327  0.09  1h 328  0.09  ferritin 329  0.09  ace 330  0.09  protein gene 331  0.09  endonuclease 332  0.08  ca 333  0.08  insulin 334  0.08  glucagon 335  0.08  diaphragmatic hernia 336  0.08  adenylate cyclase 337  0.08  plasma cholesterol 338  0.08  long bone 339  0.08  novel 340  0.08  grain 341  0.08  pi 342  0.07  na 343  0.07  fe 344  0.07  salt 345  0.07  apple 346  0.07  wheel 347  0.07  lacrimal 348  0.07  cu 349  0.07  bypass 350  0.07  sterol 351  0.07  islet 352  0.07  en 353  0.07  spike 354  0.07  glutamate receptor 355  0.07  protease 356  0.07  bad 357  0.06  year 358  0.06  vs 359  0.06  acth 360  0.06  glass 361  0.06  na k atpase 362  0.06  pb 363  0.06  prolactin 364  0.06  thrombin 365  0.06  tin 366  0.06  cd 367  0.06  rna 368  0.06  viii 369  0.06  decarboxylase 370  0.05  myocardial infarction 371  0.05  hypertension 372  0.05  signal 373  0.05  sono 374  0.05  parkinson disease 375  0.05  myo 376  0.05  pro 377  0.05  rye 378  0.05  homeless 379  0.05  circadian rhythm 380  0.05  synergistic 381  0.05  raw 382  0.05  blind 383  0.05  locus 384  0.05  key 385  0.05  oat 386  0.05  ns 387  0.04  lps 388  0.04  era 389  0.04  growth hormone 390  0.04  hen 391  0.04  alopecia 392  0.04  impact 393  0.04  ib 394  0.04  protein 395  0.04  phase 396  0.04  galpha 397  0.04  e2 398  0.04  pill 399  0.04  interferon 400  0.04  alkaline phosphatase 401  0.04  b2 402  0.04  flax 403  0.04  re 404  0.04  inhibitor 405  0.04  b1 406  0.04  term 407  0.04  kit 408  0.03  receptor 409  0.03  killer 410  0.03  nmr 411  0.03  ca2 412  0.03  immune response 413  0.03  car 414  0.03  endoplasmic reticulum 415  0.03  best 416  0.03  tau 417  0.03  gap 418  0.03  gene a 419  0.03  gt 420  0.03  phospholipase 421  0.03  albumin 422  0.03  cholesterol 423  0.03  span 424  0.03  fusion 425  0.03  york 426  0.03  peri 427  0.03  rest 428  0.03  lipase 429  0.02  cav1 430  0.02  pump 431  0.02  start 432  0.02  camp 433  0.02  aminopeptidase 434  0.02  germ 435  0.02  low 436  0.02  net 437  0.02  impact a 438  0.02  m3 439  0.02  san 440  0.02  mitochondrial 441  0.02  camel 442  0.02  csf 443  0.02  brown 444  0.02  precocious 445  0.02  gel 446  0.02  vein 447  0.02  leg 448  0.02  stop 449  0.02  swan 450  0.02  mrs 451  0.02  early 452  0.02  adr 453  0.02  analysis genome 454  0.02  beta hydroxylase 455  0.02  beta-1 456  0.02  pain 457  0.02  igg 458  0.02  transferrin 459  0.02  gut 460  0.02  tran 461  0.02  ion 462  0.02  m1 463  0.02  semi 464  0.01  dehydrogenase 465  0.01  cell 466  0.01  malt 467  0.01  tap 468  0.01  multiple sclerosis 469  0.01  k2 470  0.01  crop 471  0.01  family 472  0.01  urea 473  0.01  ani 474  0.01  leaf 475  0.01  polypeptide 476  0.01  past 477  0.01  iron 478  0.01  time 479  0.01  fragment 480  0.01  life span 481  0.01  lacking 482  0.01  c e 483  0.01  carboxypeptidase 484  0.01  aa 485  0.01  jaundice 486  0.01  hyp 487  0.01  actin 488  0.01  limb 489  0.01  heme 490  0.01  nad 491  0.01  lectin 492  0.01  cat 493  0.01  lobe 494  0.01  lens 495  0.01  asthma 496  0.01  des 497  0.01  min 498  0.01  coal 499  0.01  gaba 500  0.01  acp 501  0.01  glycoprotein 502  0.01  co 503  0.01  air 504  0.01  atp 505  0.01  not 506  0.01  tree 507  0.01  cs 508  0.01  cord 509  0.01  la 510  0.01  urinary protein 511  0.01  hemoglobin 512  0.01  thiol 513  0.01  collagen 514  0.01  or 515  0.01  lack 516  0.01  palm 517  0.01  co2 518  0.01  glucosamine 519  0.01  fiber 520  0.01  slow 521  0.00  gc 522  0.00  side 523  0.00  ray 524  0.00  doc 525  0.00  ad 526  0.00  synergistic effect 527  0.00  pig 528  0.00  east 529  0.00  gi 530  0.00  fear 531  0.00  art 532  0.00  disc 533  0.00  plasma protein 534  0.00  sex 535  0.00  ten 536  0.00  mid 537  0.00  block 538  0.00  twig 539  0.00  nord 540  0.00  trait 541  0.00  nervous 542  0.00  bed 543  0.00  cold 544  0.00  mucin 545  0.00  delta 546  0.00  pre 547  0.00  unknown 548  0.00  path 549  0.00  kappa 550  0.00  golden 551  0.00  fish 552  0.00  base 553  0.00  end 554  0.00  mn 555  0.00  unbalanced 556  0.00  segment 557  0.00  3h 558  0.00  desert 559  0.00  hope 560  0.00  safe 561  0.00  ski 562  0.00  nine 563  0.00  divergent 564  0.00  hydrolase 565  0.00  r1 566  0.00  dog 567  0.00  sense 568  0.00  el 569  0.00  clip 570  0.00  step 571  0.00  cage 572  0.00  tropic 573  0.00  l b 574  0.00  bulb 575  0.00  crest 576  0.00  ectopic 577  0.00  secretion 578  0.00  blame 579  0.00  large 580  0.00  isomerase 581  0.00  spin 582  0.00  skin 583  0.00  amp 584  0.00  ala 585  0.00  double 586  0.00  pure 587  0.00  enhancement 588  0.00  snail 589  0.00  ph 590  0.00  minor 591  0.00  po 592  0.00  h1 593  0.00  se 594  0.00  clamp 595  0.00  er 596  0.00  miniature 597  0.00  vi 598  0.00  aid 599  0.00  shear 600  0.00  gamma 601  0.00  switch 602  0.00  rib 603  0.00  id 604  0.00  hall 605  0.00  damage 606  0.00  region 607  0.00  bank 608  0.00  fit 609  0.00  olfactory 610  0.00  mix 611  0.00  little 612  0.00  2a 613  0.00  mice 614  0.00  gill 615  0.00  pas 616  0.00  light 617  0.00  red 618  0.00  run 619  0.00  point 620  0.00  membrane 621  0.00  fact 622  0.00  nova 623  0.00  ve 624  0.00  great 625  0.00  sand 626  0.00  egg 627  0.00  auto 628  0.00  mouth 629  0.00  alga 630  0.00  naked 631  0.00  inactive 632  0.00  tail 633  0.00  carp 634  0.00  bp 635  0.00  task 636  0.00  old 637  0.00  nh 638  0.00  st 639  0.00  sr 640  0.00  sick 641  0.00  ro 642  0.00  bat 643  0.00  mode 644  0.00  alpha 645  0.00  rpr 646  0.00  dark 647  0.00  rock 648  0.00  e treatment 649  0.00  steel 650  0.00  wire 651  0.00  port 652  0.00  modification 653  0.00  group 654  0.00  sea 655  0.00  ex 656  0.00  care 657  0.00  call 658  0.00  area 659  0.00  alpha1 660  0.00  pdr 661  0.00  iv 662  0.00  abnormal 663  0.00  cut 664  0.00  ho 665  0.00  ne 666  0.00  defense 667  0.00  beta 668  0.00  tube 669  0.00  ia 670  0.00  section 671  0.00  non 672  0.00  thin 673  0.00  efflux 674  0.00  di 675  0.00  simple 676  0.00  g l 677  0.00  spatial 678  0.00  man 679  0.00  sk 680  0.00  genesis 681  0.00  p e 682  0.00  live 683  0.00  ortho 684  0.00  rosa 685  0.00  wise 686  0.00  decay 687  0.00  cr 688  0.00  cape 689  0.00  sam 690  0.00  face 691  0.00  fast 692  0.00  big 693  0.00  vii 694  0.00  bar 695  0.00  e n 696  0.00  a1 697  0.00  pearl 698  0.00  spp 699  0.00  activity 700  0.00  d e 701  0.00  secret 702  0.00  sd 703  0.00  var 704  0.00  albino 705  0.00  park 706  0.00  giant 707  0.00  pan 708  0.00  l a 709  0.00  arm 710  0.00  ix 711  0.00  spring 712  0.00  wave 713  0.00  eye 714  0.00  bis 715  0.00  april 716  0.00  hand 717  0.00  band 718  0.00  lethal 719  0.00  blue 720  0.00  spot 721  0.00  far 722  0.00  fate 723  0.00  b Restrict by semantic categories?

 

 job id # 23020 started Wed Jul 28 21:56:39 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
23020 Search ARROWSMITH A
A_query_raw: Calcium Intake Wed Jul 28 21:57:01 2010

A query = Calcium Intake started Wed Jul 28 21:57:02 2010
A query resulted in 11327 titles
23020 Search ARROWSMITH C
C_query_raw: Prostate Cancer Wed Jul 28 21:57:19 2010

C: Prostate Cancer 87814

A: pubmed_query_A 11327

AC: ( Calcium Intake ) AND ( Prostate Cancer ) 105

C query = Prostate Cancer started Wed Jul 28 21:57:20 2010
C query resulted in 50000 titles
A AND C query resulted in 105 titles
13190 B-terms ready on Wed Jul 28 22:01:48 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
723 B-terms left after filter executed Wed Jul 28 22:08:01 2010

B-list on Wed Jul 28 22:09:41 2010
1 adiponectin
2 promoter polymorphism
3 codon polymorphism
4 calcium sensing receptor
5 pthrp
6 rankl
7 igfbp-3
8 ghrelin
9 akt
10 vegf
11 leptin
12 mthfr
13 single nucleotide polymorphism
14 fat mass
15 statin
16 start codon polymorphism
17 caspase
18 receptor gene cag
19 ictp
20 cannabinoid receptor
21 mros
22 phosphatidylinositol 3-kinase
23 metabolic syndrome
24 vitamin d receptor
25 leptin receptor
26 sp1
27 body mass index
28 androgen receptor gene
29 vdr gene
30 gastrin releasing peptide
31 lactase
32 bone mineral density
33 hyperparathyroidism
34 gene promoter
35 ampk
36 d pathway gene
37 codon polymorphism foki
38 tlr4
39 igf i
40 gonadotropin releasing hormone
41 e cadherin
42 igf
43 cyp3a4
44 microsatellite
45 bmd
46 gene cag repeat
47 microsatellite polymorphism
48 map kinase
49 pth
50 igfbp-2
51 p38
52 estrogen receptor
53 eralpha
54 aromatase
55 k ras
56 fibroblast growth factor
57 endothelin
58 gene promoter polymorphism
59 creb
60 leptin receptor gene
61 calcium channel
62 methylenetetrahydrofolate reductase
63 estrogen receptor gene
64 bone morphogenetic protein
65 nfat
66 igf-1
67 cd38
68 body mass
69 bone mineral content
70 hepatocyte growth factor
71 cag
72 cadherin
73 angiotensin receptor
74 osteocalcin gene
75 vdr
76 androgen receptor
77 receptor gene
78 cyclophilin
79 sirt1
80 adiposity
81 transcription factor
82 calcitonin receptor
83 han
84 tgfb1 gene
85 gene associated
86 gnrh
87 gene environment
88 responsive gene
89 igfbp-1
90 bran
91 egfr
92 erk
93 pacap
94 epidermal growth factor
95 colorectal adenoma carcinoma
96 enhancer
97 gene microsatellite
98 sun
99 tgf beta1
100 epic

Start A-Literature C-Literature B-list Filter Literature

AB literature   B-term   BC literature   Calcium Intake pthrp Prostate Cancer 1: PTH/PTHrP activity and the programming of skeletal development in utero. 2004 Add to clipboard 2: Chronic phosphorus supplementation decreases the expression of renal PTH/PTHrP receptor mRNA in rats. 2000 Add to clipboard 3: High phosphorus feeding decreases the expression of renal PTH/PTHRP-receptor mRNA in rats. 2000 Add to clipboard   1: E1A oncogene expression inhibits PTHrP P3 promoter activity and sensitizes human prostate cancer cells to TNF-induced apoptosis. 2010 Add to clipboard 2: Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. 2008 Add to clipboard 3: PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro. 2007 Add to clipboard 4: PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3). 2007 Add to clipboard 5: Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE. 2006 Add to clipboard 6: Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro. 2006 Add to clipboard 7: Skeletal metastasis: Established and emerging roles of parathyroid hormone related protein (PTHrP). 2006 Add to clipboard 8: Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP. 2005 Add to clipboard 9: Direct evidence that PTHrP expression promotes prostate cancer progression in bone. 2005 Add to clipboard 10: Bone microenvironment-related growth factors, zoledronic acid and dexamethasone differentially modulate PTHrP expression in PC-3 prostate cancer cells. 2005 Add to clipboard 11: PTHrP and skeletal metatasis. 2004 Add to clipboard 12: Prostate cancer cell type-specific regulation of the human PTHrP gene via a negative VDRE. 2003 Add to clipboard 13: Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells. 2001 Add to clipboard 14: Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues. 2001 Add to clipboard

 

 

 

 

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