免费期刊：《今日药物发现》（DDT）2014第一期

诸平

马年初一，看到2014年第一期《今日药物发现》（Drug Discovery Today ）的电子版，摘录其目录如下，作为一种马年初一的文化大餐，奉献给关心药学研究的朋友。

FOUNDATION

8 Tailoring chronic pain treatments for the elderly: are we prepared for the challenge?

Stephen P. Arneric, Jennifer M.A. Laird, Amy S. Chappell and Jeffrey D. Kennedy

18 Thymoquinone: fi fty years of success in the battle against cancer models

Regine Schneider-Stock, Isabelle H. Fakhoury, Angela M. Zaki, Chirine O. El-Baba and Hala U. Gali-Muhtasib

KEYNOTE

31 Toward the practical implementation of eye-related bioavailability prediction models

Ivan Pepi′c, Jasmina Lovri′c, Biserka Cetina-Cˇižmek, Stephan Reichl and Jelena Filipovi′c-Grcˇi′c

INFORMATICS

45 Fragment-based error estimation in biomolecular modeling

John C. Faver and Kenneth M. Merz Jr.

POST SCREEN

51 Current strategies for inhibiting FGFR activities in clinical applications: opportunities, challenges and toxicological considerations

Han Kiat Ho, Angie Hui Ling Yeo, Tse Siang Kang and Boon Tin Chua

63 Human pregnane X receptor: a novel target for anticancer drug development

Vijay Rathod, Sumit Jain, Prajwal Nandekar and Abhay T. Sangamwar

71 Strategies and validation for siRNA-based therapeutics for the reversal of multi-drug resistance in cancer

Tahereh Fatemian, Iekhsan Othman and Ezharul Hoque Chowdhury

79 Chemistry-enabled drug delivery (prodrugs): recent progress and challenges

Sophie-Dorothee Clas, Rosa I. Sanchez and Rebecca Nofsinger

88 Biofunctionalisation of electrically conducting polymers

Catalina Vallejo-Giraldo, Adriona Kelly and Manus J.P. Biggs

95 Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Hui Wei, Jingjie Mo, Li Tao, Reb J. Russell, Adrienne A. Tymiak, Guodong Chen, Roxana E. Iacob

and John R. Engen

EDITORIAL

1 Making drug development visible – and viable

Roger Gunn and Ilan Rabiner

PERSPECTIVE

FEATURE

4 Traditional use of medicinal agents: a valid source of evidence

Axel Helmstädter and Christiane Staiger

103 DIARY

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The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» The latest issue highlights includes: Tailoring chronic pain treatments for the elderly Inhibiting FGFR activities for clinical applications Fragment-based error estimation in bimolecular  modeling Human pregnane X receptor Remember - reading Drug Discovery Today is easy and free - you can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2014/01/01 Enjoy your digital edition! Drug Discovery Today www.drugdiscoverytoday.com

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